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MX_PERFL
ID   MX_PERFL                Reviewed;         301 AA.
AC   P20593;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Interferon-induced GTP-binding protein Mx;
DE   AltName: Full=Interferon-inducible Mx protein;
DE   Flags: Fragment;
GN   Name=mx;
OS   Perca fluviatilis (European perch).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Percoidei; Percidae; Percinae; Perca.
OX   NCBI_TaxID=8168;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2476661; DOI=10.1128/mcb.9.7.3117-3121.1989;
RA   Staeheli P., Yu Y.X., Grob R., Haller O.;
RT   "A double-stranded RNA-inducible fish gene homologous to the murine
RT   influenza virus resistance gene Mx.";
RL   Mol. Cell. Biol. 9:3117-3121(1989).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: By interferons.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01055}.
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DR   EMBL; M27252; AAA72778.1; -; Genomic_DNA.
DR   PIR; A32498; A32498.
DR   AlphaFoldDB; P20593; -.
DR   SMR; P20593; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd08771; DLP_1; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR019762; Dynamin_GTPase_CS.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; PTHR11566; 1.
DR   Pfam; PF01031; Dynamin_M; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00410; G_DYNAMIN_1; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding.
FT   CHAIN           <1..301
FT                   /note="Interferon-induced GTP-binding protein Mx"
FT                   /id="PRO_0000206605"
FT   DOMAIN          32..>301
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          42..49
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          67..69
FT                   /note="G2 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          143..146
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          212..215
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          244..247
FT                   /note="G5 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   BINDING         42..49
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         143..147
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         212..215
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         301
SQ   SEQUENCE   301 AA;  33325 MW;  45EEC91B3F18B843 CRC64;
     ITMNTLNQQY EEKVRPCIDL IDSLRSLGVE KDLALPAIAV IGDQSSGKSS VLEALSGVAL
     PRGSGIVTRC PLELKMKRRQ EGEEWYGKIS YQDCEKEIED PADVEKKIRD AQDEMAGVGV
     GISDDLISLE IASPDVPDLT LIDLPGIARV AVKGQPENIG DQIKRLIQKF IKRQETISLV
     VVPCNVDIAT TEALKMAQEV DPDGERTLGI LTKPDLVDKG TEETVVDIVH NEVIPLKKGY
     MIVRCRGQKD ITDKVSLTEA IEREKAFFND HVHFQTLYND GHATVPKLAE KLTLELVHHI
     E
 
 
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