MX_PERFL
ID MX_PERFL Reviewed; 301 AA.
AC P20593;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Interferon-induced GTP-binding protein Mx;
DE AltName: Full=Interferon-inducible Mx protein;
DE Flags: Fragment;
GN Name=mx;
OS Perca fluviatilis (European perch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Percoidei; Percidae; Percinae; Perca.
OX NCBI_TaxID=8168;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2476661; DOI=10.1128/mcb.9.7.3117-3121.1989;
RA Staeheli P., Yu Y.X., Grob R., Haller O.;
RT "A double-stranded RNA-inducible fish gene homologous to the murine
RT influenza virus resistance gene Mx.";
RL Mol. Cell. Biol. 9:3117-3121(1989).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- INDUCTION: By interferons.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC ProRule:PRU01055}.
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DR EMBL; M27252; AAA72778.1; -; Genomic_DNA.
DR PIR; A32498; A32498.
DR AlphaFoldDB; P20593; -.
DR SMR; P20593; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; PTHR11566; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; GTP-binding; Nucleotide-binding.
FT CHAIN <1..301
FT /note="Interferon-induced GTP-binding protein Mx"
FT /id="PRO_0000206605"
FT DOMAIN 32..>301
FT /note="Dynamin-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 42..49
FT /note="G1 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 67..69
FT /note="G2 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 143..146
FT /note="G3 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 212..215
FT /note="G4 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT REGION 244..247
FT /note="G5 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT BINDING 42..49
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 143..147
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 212..215
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT NON_TER 1
FT NON_TER 301
SQ SEQUENCE 301 AA; 33325 MW; 45EEC91B3F18B843 CRC64;
ITMNTLNQQY EEKVRPCIDL IDSLRSLGVE KDLALPAIAV IGDQSSGKSS VLEALSGVAL
PRGSGIVTRC PLELKMKRRQ EGEEWYGKIS YQDCEKEIED PADVEKKIRD AQDEMAGVGV
GISDDLISLE IASPDVPDLT LIDLPGIARV AVKGQPENIG DQIKRLIQKF IKRQETISLV
VVPCNVDIAT TEALKMAQEV DPDGERTLGI LTKPDLVDKG TEETVVDIVH NEVIPLKKGY
MIVRCRGQKD ITDKVSLTEA IEREKAFFND HVHFQTLYND GHATVPKLAE KLTLELVHHI
E