ID   MX_SINCH                Reviewed;         626 AA.
AC   Q6TN15;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Interferon-induced GTP-binding protein Mx;
DE   AltName: Full=Interferon-inducible Mx protein;
GN   Name=mx;
OS   Siniperca chuatsi (Mandarin fish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Centrarchiformes; Centrarchoidei; Sinipercidae; Siniperca.
OX   NCBI_TaxID=119488;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wu H., Bai J., Lao H., Ye X., Jian Q., Luo J.;
RT   "The cDNA cloning and sequence analysis of mandarinfish Mx gene.";
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: By interferons.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01055}.
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DR   EMBL; AY392097; AAQ91382.1; -; mRNA.
DR   AlphaFoldDB; Q6TN15; -.
DR   SMR; Q6TN15; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd08771; DLP_1; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR019762; Dynamin_GTPase_CS.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR003130; GED.
DR   InterPro; IPR020850; GED_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; PTHR11566; 1.
DR   Pfam; PF01031; Dynamin_M; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF02212; GED; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SMART; SM00302; GED; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00410; G_DYNAMIN_1; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
DR   PROSITE; PS51388; GED; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding.
FT   CHAIN           1..626
FT                   /note="Interferon-induced GTP-binding protein Mx"
FT                   /id="PRO_0000292876"
FT   DOMAIN          30..303
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   DOMAIN          540..626
FT                   /note="GED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00720"
FT   REGION          40..47
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          65..67
FT                   /note="G2 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          141..144
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          210..213
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          242..245
FT                   /note="G5 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   BINDING         40..47
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         141..145
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         210..213
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   626 AA;  71431 MW;  CD1E1EACDD4F7B0F CRC64;
     MNTLNQQYEE KVRPCIDLID SLRSLGVEKD LALPAIAVIG DQSSGKSSVL EALSGVALPR
     GSGIVTRCPL ELKMKRKKEG EEWYGKISYQ NHEEEIEDPA DVEKKIREAQ DEMAGVGVGI
     SDDLISLEIG SPGVPDLTLI DLPGIARVAV KGQPENIGDQ IKRLIQTFIT KQETISLVVV
     PCNVDIATTE ALNMAQRVDP DGERTLGILT KPDLVDKGTE DTVVEIVHNE VIHLKKGYMI
     VKCRGQKEIT ERVSLTEAIE RETAFFREHV YFHTLYNEGH ATVPKLAEKL TLELVHHIEK
     SLPRLEEQIE EKLTQTRAEL ERYGNGPPSD AAEKLIFLID KVTAFTQDAI SLTTGEELKC
     GDRLNVFSML RREFGQWNAH LSRSGEIFNK KIEKEVEEYE ERYRGRELPG FINYKTFEVM
     VKEQIKQLEE PAVKRLKDVG DAVRKLLVQL AQSSFTGFPN LVKIAKARIE AIKQEKESTA
     ESTLRTQFKM ELLVYSQDRT YSSSLSDRKT EEDEEEDKRK VKTFHKERSI LYRMDNHATL
     QELMLHLKSY YKIASQRLAD QIPLVIRYQM LQESASQLHR EMMQVLQDKE NLEFLLKEDS
     DIGSKRAALQ SRLKRLMKAR AYLVEF