ID   MX_SOLSE                Reviewed;         623 AA.
AC   Q5U752;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Interferon-induced GTP-binding protein Mx;
DE   AltName: Full=Interferon-inducible Mx protein;
GN   Name=mx;
OS   Solea senegalensis (Senegalese sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Soleidae; Solea.
OX   NCBI_TaxID=28829;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Fernandez-Trujillo M.A., Bejar J., Porta J., Borrego J.J., Alvarez M.C.;
RT   "Cloning and expression analysis of Mx cDNA from the sole fish Solea
RT   senegalensis.";
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: By interferons.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01055}.
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DR   EMBL; AY790537; AAV49303.1; -; mRNA.
DR   AlphaFoldDB; Q5U752; -.
DR   SMR; Q5U752; -.
DR   PRIDE; Q5U752; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd08771; DLP_1; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR019762; Dynamin_GTPase_CS.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR003130; GED.
DR   InterPro; IPR020850; GED_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; PTHR11566; 1.
DR   Pfam; PF01031; Dynamin_M; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF02212; GED; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SMART; SM00302; GED; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00410; G_DYNAMIN_1; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
DR   PROSITE; PS51388; GED; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding.
FT   CHAIN           1..623
FT                   /note="Interferon-induced GTP-binding protein Mx"
FT                   /id="PRO_0000292877"
FT   DOMAIN          30..303
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   DOMAIN          537..623
FT                   /note="GED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00720"
FT   REGION          40..47
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          65..67
FT                   /note="G2 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          141..144
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          210..213
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          242..245
FT                   /note="G5 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          504..527
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         40..47
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         141..145
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         210..213
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   623 AA;  71066 MW;  CC1473E90202D965 CRC64;
     MTNLNEQYEE KVRPCIDLID SLRSLGVEKD LALPAIAVIG DQSSGKSSVL EALSGVALPR
     GSGIVTRCPL ELKMKRKNDG EGWQGKISYQ DHEEEIQDPA DVEKKIEEAQ IQIAGVGVGI
     SENMISLEIA SPDVPDLTLI DLPGITRVAV HGQPVNIGEQ IKKLIHKFIT KQETICLVVH
     ACNVDLATTE ALQMAQEEDP EGERTLGILT KPDLVDKGTE QMVIDILQNE VIHLKKGYMI
     VRCRGQQEIM QKVSLAEAIE REKAFFADHA HFCSLYDDGQ ATVPRLAEKL TLELVHHIEK
     SLPRLEEQIE EKLEQAQAEL VRYGTGPPSD AAERLYFLID KVTAFTQDTI SLAAGEELRC
     GEKLNIFSAL RREFDKWSIH LSHTGQKFNA RIDKEVAIYE DKYRGRELPG FINYKTFEVM
     VKEQIKQLEE PAVKKLRDIA DAVRKLFLQL AQCSFTGFPN LVKTAKAKIE TIKLERESTA
     ESMLRTQFKM EMIVYSQDRT YSNSLSDRKK EESEEEERRK GPKLHKERNC MDNHATLQEL
     MLHLKSYYNI ASQRLADQVP MVIRYQMLQE SAVQLQRQMM QMMQDKENME FLLKEDLNIG
     CKRATLQSRI KRLMKARAYL MEF