MY108_ARATH
ID MY108_ARATH Reviewed; 323 AA.
AC Q9LDE1; Q6R095;
DT 11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 154.
DE RecName: Full=Transcription factor MYB108;
DE AltName: Full=Myb-related protein 108;
DE Short=AtMYB108;
DE AltName: Full=Protein BOTRYTIS-SUSCEPTIBLE 1;
GN Name=MYB108; Synonyms=BOS1; OrderedLocusNames=At3g06490; ORFNames=F5E6.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION BY PATHOGEN.
RX PubMed=14555693; DOI=10.1105/tpc.014167;
RA Mengiste T., Chen X., Salmeron J., Dietrich R.;
RT "The BOTRYTIS SUSCEPTIBLE1 gene encodes an R2R3MYB transcription factor
RT protein that is required for biotic and abiotic stress responses in
RT Arabidopsis.";
RL Plant Cell 15:2551-2565(2003).
RN [6]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND INDUCTION BY
RP JASMONATE.
RX PubMed=19091873; DOI=10.1104/pp.108.132597;
RA Mandaokar A., Browse J.;
RT "MYB108 acts together with MYB24 to regulate jasmonate-mediated stamen
RT maturation in Arabidopsis.";
RL Plant Physiol. 149:851-862(2009).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BOI AND BRG1, AND
RP UBIQUITINATION.
RX PubMed=20921156; DOI=10.1104/pp.110.163915;
RA Luo H., Laluk K., Lai Z., Veronese P., Song F., Mengiste T.;
RT "The Arabidopsis Botrytis Susceptible1 Interactor defines a subclass of
RT RING E3 ligases that regulate pathogen and stress responses.";
RL Plant Physiol. 154:1766-1782(2010).
RN [8]
RP FUNCTION.
RX PubMed=23952703; DOI=10.1111/nph.12456;
RA Cui F., Brosche M., Sipari N., Tang S., Overmyer K.;
RT "Regulation of ABA dependent wound induced spreading cell death by
RT MYB108.";
RL New Phytol. 200:634-640(2013).
CC -!- FUNCTION: Transcription factor contributing to the regulation of stamen
CC maturation and male fertility in response to jasmonate signaling.
CC Required for correct timing of anther dehiscence. Acts as a negative
CC regulator of abscisic acid-induced cell death. Not involved in the
CC regulation of BOI. Regulated by MYB21 and at a lower level by MYB24.
CC Negatively regulated by the proteasome in an SCF(COI1) E3 ubiquitin-
CC protein ligase complex-dependent manner. {ECO:0000269|PubMed:14555693,
CC ECO:0000269|PubMed:19091873, ECO:0000269|PubMed:20921156,
CC ECO:0000269|PubMed:23952703}.
CC -!- SUBUNIT: Interacts with BOI, but not with BRG1.
CC {ECO:0000269|PubMed:20921156}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:20921156}.
CC -!- TISSUE SPECIFICITY: Expressed specifically in flowers. Restricted to
CC anthers in maturing flowers. Strongest expression in the vascular and
CC connective tissue where the anther attaches to the filament. Not
CC detected in pollen. {ECO:0000269|PubMed:19091873}.
CC -!- INDUCTION: Up-regulated by jasmonate and pathogen infection.
CC {ECO:0000269|PubMed:14555693, ECO:0000269|PubMed:19091873}.
CC -!- PTM: Ubiquitinated in vitro by BOI. {ECO:0000269|PubMed:20921156}.
CC -!- DISRUPTION PHENOTYPE: Reduced male fertility associated with delayed
CC anther dehiscence, reduced pollen viability and decreased fecundity.
CC Increased susceptibility to Botrytis infection. Myb24 and myb108 double
CC mutant has a reduced fertility and a greatly reduced seed set relative
CC to the myb108 parental allele. {ECO:0000269|PubMed:14555693,
CC ECO:0000269|PubMed:19091873}.
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DR EMBL; AF262733; AAF72668.1; -; mRNA.
DR EMBL; AY519584; AAS10054.1; -; mRNA.
DR EMBL; AC020580; AAG51322.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74402.1; -; Genomic_DNA.
DR RefSeq; NP_187301.1; NM_111525.4.
DR AlphaFoldDB; Q9LDE1; -.
DR SMR; Q9LDE1; -.
DR BioGRID; 5162; 6.
DR IntAct; Q9LDE1; 2.
DR STRING; 3702.AT3G06490.1; -.
DR PaxDb; Q9LDE1; -.
DR PRIDE; Q9LDE1; -.
DR ProteomicsDB; 251254; -.
DR EnsemblPlants; AT3G06490.1; AT3G06490.1; AT3G06490.
DR GeneID; 819827; -.
DR Gramene; AT3G06490.1; AT3G06490.1; AT3G06490.
DR KEGG; ath:AT3G06490; -.
DR Araport; AT3G06490; -.
DR TAIR; locus:2084269; AT3G06490.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_8_2_1; -.
DR InParanoid; Q9LDE1; -.
DR OMA; WFEDING; -.
DR OrthoDB; 953139at2759; -.
DR PhylomeDB; Q9LDE1; -.
DR PRO; PR:Q9LDE1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LDE1; baseline and differential.
DR Genevisible; Q9LDE1; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0008219; P:cell death; IMP:TAIR.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0120195; P:positive regulation of anther dehiscence; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0009620; P:response to fungus; IMP:TAIR.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR044676; EOBI/EOBII-like_plant.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR45675; PTHR45675; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Plant defense; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Ubl conjugation.
FT CHAIN 1..323
FT /note="Transcription factor MYB108"
FT /id="PRO_0000424714"
FT DOMAIN 16..68
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 69..123
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 44..68
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 96..119
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT CONFLICT 214
FT /note="S -> F (in Ref. 2; AAS10054)"
FT /evidence="ECO:0000305"
FT CONFLICT 292
FT /note="A -> V (in Ref. 2; AAS10054)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 323 AA; 37020 MW; BB0FF0A362192165 CRC64;
MDEKGRSLKN NNMEDEMDLK RGPWTAEEDF KLMNYIATNG EGRWNSLSRC AGLQRTGKSC
RLRWLNYLRP DVRRGNITLE EQLLILELHS RWGNRWSKIA QYLPGRTDNE IKNYWRTRVQ
KHAKQLKCDV NSQQFKDTMK YLWMPRLVER IQSASASSAA AATTTTTTTT GSAGTSSCIT
TSNNQFMNYD YNNNNMGQQF GVMSNNDYIT PENSSVAVSP ASDLTEYYSA PNPNPEYYSG
QMGNSYYPDQ NLVSSQLLPD NYFDYSGLLD EDLTAMQEQS NLSWFENING AASSSDSLWN
IGETDEEFWF LQQQQQFNNN GSF
