MY117_ARATH
ID MY117_ARATH Reviewed; 359 AA.
AC Q9LQX5; A0ME93; Q9C5P9;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Transcription factor MYB117 {ECO:0000305};
DE AltName: Full=MYB-domain transcription factor LOF1 {ECO:0000303|PubMed:19542355};
DE AltName: Full=Myb-related protein 117 {ECO:0000305};
DE Short=AtMYB117 {ECO:0000303|PubMed:11597504};
DE AltName: Full=Protein CONSTRICTED FRUIT {ECO:0000303|PubMed:21533201};
DE AltName: Full=Protein LATERAL ORGAN FUSION 1 {ECO:0000303|PubMed:19542355};
GN Name=MYB117 {ECO:0000303|PubMed:11597504};
GN Synonyms=CTF {ECO:0000303|PubMed:21533201},
GN LOF1 {ECO:0000303|PubMed:19542355};
GN OrderedLocusNames=At1g26780 {ECO:0000312|Araport:AT1G26780};
GN ORFNames=T24P13.16 {ECO:0000312|EMBL:AAF87032.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: A genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=19542355; DOI=10.1242/dev.031971;
RA Lee D.K., Geisler M., Springer P.S.;
RT "LATERAL ORGAN FUSION1 and LATERAL ORGAN FUSION2 function in lateral organ
RT separation and axillary meristem formation in Arabidopsis.";
RL Development 136:2423-2432(2009).
RN [7]
RP FUNCTION.
RX PubMed=21533201; DOI=10.1371/journal.pone.0018760;
RA Gomez M.D., Urbez C., Perez-Amador M.A., Carbonell J.;
RT "Characterization of constricted fruit (ctf) mutant uncovers a role for
RT AtMYB117/LOF1 in ovule and fruit development in Arabidopsis thaliana.";
RL PLoS ONE 6:E18760-E18760(2011).
CC -!- FUNCTION: Probable transcription factor that involved in boundary
CC specification, meristem initiation and maintenance, and organ
CC patterning (PubMed:19542355, PubMed:21533201). Functions in both
CC lateral organ separation and axillary meristem formation, in part
CC through genetic interaction with the NAC domain genes CUC2 and CUC3 and
CC the homeobox gene STM (PubMed:19542355). May be recruited by a variety
CC of developmental programs for the development of floral organs and the
CC initiation of ovule outgrowth (PubMed:21533201).
CC {ECO:0000269|PubMed:19542355, ECO:0000269|PubMed:21533201}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9LQX5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9LQX5-2; Sequence=VSP_058882, VSP_058883;
CC -!- TISSUE SPECIFICITY: Expressed in organ boundaries.
CC {ECO:0000269|PubMed:19542355}.
CC -!- DISRUPTION PHENOTYPE: Defects in organ separation due to abnormal cell
CC division and expansion during early boundary formation. Failure in
CC accessory shoot meristem formation. {ECO:0000269|PubMed:19542355}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK28416.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF334816; AAK25749.1; -; mRNA.
DR EMBL; AY519559; AAS10029.1; -; mRNA.
DR EMBL; AC006535; AAF87032.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30735.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30736.1; -; Genomic_DNA.
DR EMBL; DQ446291; ABE65656.1; -; mRNA.
DR EMBL; DQ652862; ABK28416.1; ALT_SEQ; mRNA.
DR PIR; D86394; D86394.
DR RefSeq; NP_001154369.1; NM_001160897.2. [Q9LQX5-1]
DR RefSeq; NP_564261.1; NM_102441.3. [Q9LQX5-2]
DR AlphaFoldDB; Q9LQX5; -.
DR SMR; Q9LQX5; -.
DR IntAct; Q9LQX5; 31.
DR STRING; 3702.AT1G26780.2; -.
DR PaxDb; Q9LQX5; -.
DR PRIDE; Q9LQX5; -.
DR EnsemblPlants; AT1G26780.1; AT1G26780.1; AT1G26780. [Q9LQX5-2]
DR EnsemblPlants; AT1G26780.2; AT1G26780.2; AT1G26780. [Q9LQX5-1]
DR GeneID; 839219; -.
DR Gramene; AT1G26780.1; AT1G26780.1; AT1G26780. [Q9LQX5-2]
DR Gramene; AT1G26780.2; AT1G26780.2; AT1G26780. [Q9LQX5-1]
DR KEGG; ath:AT1G26780; -.
DR Araport; AT1G26780; -.
DR TAIR; locus:2200635; AT1G26780.
DR eggNOG; KOG0048; Eukaryota.
DR InParanoid; Q9LQX5; -.
DR OMA; FGNQMMV; -.
DR PhylomeDB; Q9LQX5; -.
DR PRO; PR:Q9LQX5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LQX5; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0010199; P:organ boundary specification between lateral organs and the meristem; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; DNA-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation.
FT CHAIN 1..359
FT /note="Transcription factor MYB117"
FT /id="PRO_0000439515"
FT DOMAIN 93..144
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 145..199
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 121..143
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 172..195
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 57..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 279..280
FT /note="YE -> SL (in isoform 2)"
FT /id="VSP_058882"
FT VAR_SEQ 281..359
FT /note="Missing (in isoform 2)"
FT /id="VSP_058883"
SQ SEQUENCE 359 AA; 41534 MW; 85CBD316DC349ABC CRC64;
MFITEKQVWM DEIVARRASS SWDFPFNDIN IHQHHHRHCN TSHEFEILKS PLGDVAVHEE
ESNNNNPNFS NSESGKKETT DSGQSWSSSS SKPSVLGRGH WRPAEDVKLK ELVSIYGPQN
WNLIAEKLQG RSGKSCRLRW FNQLDPRINR RAFTEEEEER LMQAHRLYGN KWAMIARLFP
GRTDNSVKNH WHVVMARKYR EHSSAYRRRK LMSNNPLKPH LTNNHHPNPN PNYHSFISTN
HYFAQPFPEF NLTHHLVNNA PITSDHNQLV LPFHCFQGYE NNEPPMVVSM FGNQMMVGDN
VGATSDALCN IPHIDPSNQE KPEPNDAMHW IGMDAVDEEV FEKAKQQPHF FDFLGLGTA
