MY118_ARATH
ID MY118_ARATH Reviewed; 437 AA.
AC Q9LVW4; A0MEY8; Q6QAD0; Q9C5P8;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Transcription factor MYB118 {ECO:0000303|PubMed:11597504};
DE AltName: Full=Myb-related protein 118 {ECO:0000303|PubMed:11597504};
DE Short=AtMYB118 {ECO:0000303|PubMed:11597504};
DE AltName: Full=Protein PLANT GROWTH ACTIVATOR 37 {ECO:0000303|PubMed:18695688};
GN Name=MYB118 {ECO:0000303|PubMed:11597504};
GN Synonyms=PGA37 {ECO:0000303|PubMed:18695688};
GN OrderedLocusNames=At3g27785 {ECO:0000312|Araport:AT3G27785};
GN ORFNames=MGF10.18 {ECO:0000312|EMBL:BAB02701.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [6]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=cv. Columbia, cv. Landsberg erecta, and cv. Wassilewskija;
RX PubMed=18695688; DOI=10.1038/cr.2008.276;
RA Wang X., Niu Q.-W., Teng C., Li C., Mu J., Chua N.-H., Zuo J.;
RT "Overexpression of PGA37/MYB118 and MYB115 promotes vegetative-to-embryonic
RT transition in Arabidopsis.";
RL Cell Res. 19:224-235(2009).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=cv. Columbia;
RX PubMed=19066902; DOI=10.1007/s00299-008-0644-4;
RA Zhang Y., Cao G., Qu L.-J., Gu H.;
RT "Involvement of an R2R3-MYB transcription factor gene AtMYB118 in
RT embryogenesis in Arabidopsis.";
RL Plant Cell Rep. 28:337-346(2009).
RN [8]
RP FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, AND INDUCTION BY LEC2.
RC STRAIN=cv. Columbia;
RX PubMed=25194028; DOI=10.1105/tpc.114.130021;
RA Barthole G., To A., Marchive C., Brunaud V., Soubigou-Taconnat L.,
RA Berger N., Dubreucq B., Lepiniec L., Baud S.;
RT "MYB118 represses endosperm maturation in seeds of Arabidopsis.";
RL Plant Cell 26:3519-3537(2014).
RN [9]
RP FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=27681170; DOI=10.1105/tpc.16.00612;
RA Troncoso-Ponce M.A., Barthole G., Tremblais G., To A., Miquel M.,
RA Lepiniec L., Baud S.;
RT "Transcriptional activation of two palmitoyl-ACP delta9 desaturase genes by
RT MYB115 and MYB118 is critical for biosynthesis of omega-7 monounsaturated
RT fatty acid in the endosperm of Arabidopsis seeds.";
RL Plant Cell 28:2666-2682(2016).
CC -!- FUNCTION: Transcription activator that recognizes the motif 5'-TAACGG-
CC 3' in the promoter of endosperm-induced genes (PubMed:27681170,
CC PubMed:25194028, PubMed:19066902). Promotes vegetative-to-embryonic
CC transition and the formation of somatic embryos from root explants in a
CC WUS-independent manner but via the expression of embryonic genes (e.g.
CC LEC1, LEC2, FUS3 and WUS) (PubMed:18695688). May play an important role
CC during embryogenesis and seed maturation (PubMed:19066902,
CC PubMed:25194028). Together with MYB115, activates the transcription of
CC S-ACP-DES2/AAD2 and S-ACP-DES3/AAD3 thus promoting the biosynthesis of
CC omega-7 monounsaturated fatty acid in seed endosperm (PubMed:27681170).
CC Regulates negatively maturation genes in the endosperm
CC (PubMed:25194028). {ECO:0000269|PubMed:18695688,
CC ECO:0000269|PubMed:19066902, ECO:0000269|PubMed:25194028,
CC ECO:0000269|PubMed:27681170}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:19066902,
CC ECO:0000269|PubMed:27681170}.
CC -!- TISSUE SPECIFICITY: Mainly expressed in siliques (PubMed:18695688,
CC PubMed:19066902). Also detected at low levels in leaves and flowers
CC (PubMed:19066902). {ECO:0000269|PubMed:18695688,
CC ECO:0000269|PubMed:19066902}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryos from the early heart stage
CC and throughout embryogenesis (PubMed:18695688, PubMed:19066902).
CC Induced at the onset of the maturation phase in the endosperm, in a
CC high and homogeneous repartition (PubMed:18695688, PubMed:19066902,
CC PubMed:25194028, PubMed:27681170). {ECO:0000269|PubMed:18695688,
CC ECO:0000269|PubMed:19066902, ECO:0000269|PubMed:25194028,
CC ECO:0000269|PubMed:27681170}.
CC -!- INDUCTION: Induced by LEC2. {ECO:0000269|PubMed:25194028}.
CC -!- DISRUPTION PHENOTYPE: Single and myb118 myb115 double mutants do not
CC show apparent developmental abnormalities (PubMed:18695688,
CC PubMed:25194028). Reduced omega-7 fatty acids accumulation in the
CC endosperm. The endosperm oil of double mutant myb115 myb118 lacks
CC omega-7 fatty acids (PubMed:27681170). Endosperm-specific derepression
CC of maturation-related genes associated with a partial relocation of
CC storage compounds from the embryo to the endosperm (PubMed:25194028).
CC {ECO:0000269|PubMed:18695688, ECO:0000269|PubMed:25194028,
CC ECO:0000269|PubMed:27681170}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK28575.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF334817; AAK25750.2; -; mRNA.
DR EMBL; AY550306; AAS58517.1; -; mRNA.
DR EMBL; AB018114; BAB02701.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77363.1; -; Genomic_DNA.
DR EMBL; DQ446708; ABE65974.1; -; mRNA.
DR EMBL; DQ653111; ABK28575.1; ALT_SEQ; mRNA.
DR RefSeq; NP_189416.2; NM_113694.2.
DR AlphaFoldDB; Q9LVW4; -.
DR SMR; Q9LVW4; -.
DR IntAct; Q9LVW4; 5.
DR STRING; 3702.AT3G27785.1; -.
DR PaxDb; Q9LVW4; -.
DR PRIDE; Q9LVW4; -.
DR EnsemblPlants; AT3G27785.1; AT3G27785.1; AT3G27785.
DR GeneID; 822399; -.
DR Gramene; AT3G27785.1; AT3G27785.1; AT3G27785.
DR KEGG; ath:AT3G27785; -.
DR Araport; AT3G27785; -.
DR TAIR; locus:2829519; AT3G27785.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_045900_0_0_1; -.
DR InParanoid; Q9LVW4; -.
DR OMA; QMRRICK; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q9LVW4; -.
DR PRO; PR:Q9LVW4; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LVW4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0009960; P:endosperm development; IGI:TAIR.
DR GO; GO:0055089; P:fatty acid homeostasis; IMP:UniProtKB.
DR GO; GO:1904095; P:negative regulation of endosperm development; IMP:TAIR.
DR GO; GO:2000692; P:negative regulation of seed maturation; IMP:TAIR.
DR GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IGI:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:2001280; P:positive regulation of unsaturated fatty acid biosynthetic process; IMP:UniProtKB.
DR GO; GO:0045995; P:regulation of embryonic development; IMP:UniProtKB.
DR GO; GO:2000014; P:regulation of endosperm development; IMP:UniProtKB.
DR GO; GO:0010439; P:regulation of glucosinolate biosynthetic process; IGI:TAIR.
DR GO; GO:2000034; P:regulation of seed maturation; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0010262; P:somatic embryogenesis; IMP:UniProtKB.
DR GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:UniProtKB.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..437
FT /note="Transcription factor MYB118"
FT /id="PRO_0000438621"
FT DOMAIN 184..239
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 240..290
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 212..235
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 263..286
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT MOTIF 152..159
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT CONFLICT 73
FT /note="E -> G (in Ref. 2; AAS58517)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 437 AA; 49492 MW; 33F5959DD8728213 CRC64;
MEFESVFKMH YPYLAAVIYD DSSTLKDFHP SLTDDFSCVH NVHHKPSMPH TYEIPSKETI
RGITPSPCTE AFEACFHGTS NDHVFFGMAY TTPPTIEPNV SHVSHDNTMW ENDQNQGFIF
GTESTLNQAM ADSNQFNMPK PLLSANEDTI MNRRQNNQVM IKTEQIKKKN KRFQMRRICK
PTKKASIIKG QWTPEEDKLL VQLVDLHGTK KWSQIAKMLQ GRVGKQCRER WHNHLRPDIK
KDGWTEEEDI ILIKAHKEIG NRWAEIARKL PGRTENTIKN HWNATKRRQH SRRTKGKDEI
SLSLGSNTLQ NYIRSVTYND DPFMTANANA NIGPRNMRGK GKNVMVAVSE YDEGECKYIV
DGVNNLGLED GRIKMPSLAA MSASGSASTS GSASGSGSGV TMEIDEPMTD SWMVMHGCDE
VMMNEIALLE MIAHGRL
