MY124_ARATH
ID MY124_ARATH Reviewed; 436 AA.
AC Q94FL6; Q9M9S7;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Transcription factor MYB124 {ECO:0000303|PubMed:11597504};
DE AltName: Full=Myb-related protein 124 {ECO:0000303|PubMed:11597504};
DE Short=AtMYB124 {ECO:0000303|PubMed:11597504};
DE AltName: Full=Protein FOUR LIPS {ECO:0000303|PubMed:11536724};
GN Name=MYB124 {ECO:0000303|PubMed:11597504};
GN Synonyms=FLP {ECO:0000303|PubMed:11536724};
GN OrderedLocusNames=At1g14350 {ECO:0000312|Araport:AT1G14350};
GN ORFNames=F14L17.12 {ECO:0000312|EMBL:AAF43935.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Quinitio C., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=11536724; DOI=10.2307/3870164;
RA Yang M., Sack F.D.;
RT "The too many mouths and four lips mutations affect stomatal production in
RT Arabidopsis.";
RL Plant Cell 7:2227-2239(1995).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. C24, and cv. Columbia;
RX PubMed=9684356; DOI=10.1007/s004250050351;
RA Geisler M., Yang M., Sack F.D.;
RT "Divergent regulation of stomatal initiation and patterning in organ and
RT suborgan regions of the Arabidopsis mutants too many mouths and four
RT lips.";
RL Planta 205:522-530(1998).
RN [7]
RP REVIEW ON STOMATAL DEVELOPMENT.
RX PubMed=11641073; DOI=10.1016/s1369-5266(00)00215-6;
RA von Groll U., Altmann T.;
RT "Stomatal cell biology.";
RL Curr. Opin. Plant Biol. 4:555-560(2001).
RN [8]
RP REVIEW ON STOMATAL DEVELOPMENT.
RX PubMed=22303215; DOI=10.1199/tab.0066;
RA Nadeau J.A., Sack F.D.;
RT "Stomatal development in Arabidopsis.";
RL Arabidopsis Book 1:E0066-E0066(2002).
RN [9]
RP FUNCTION, DISRUPTION PHENOTYPE, MUTAGENESIS OF GLU-84, AND TISSUE
RP SPECIFICITY.
RC STRAIN=cv. C24, cv. Columbia, and cv. Landsberg erecta;
RX PubMed=16155180; DOI=10.1105/tpc.105.034116;
RA Lai L.B., Nadeau J.A., Lucas J., Lee E.-K., Nakagawa T., Zhao L.,
RA Geisler M., Sack F.D.;
RT "The Arabidopsis R2R3 MYB proteins FOUR LIPS and MYB88 restrict divisions
RT late in the stomatal cell lineage.";
RL Plant Cell 17:2754-2767(2005).
RN [10]
RP FUNCTION, DISRUPTION PHENOTYPE, MUTAGENESIS OF GLU-84, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=20675570; DOI=10.1105/tpc.110.074609;
RA Xie Z., Lee E., Lucas J.R., Morohashi K., Li D., Murray J.A., Sack F.D.,
RA Grotewold E.;
RT "Regulation of cell proliferation in the stomatal lineage by the
RT Arabidopsis MYB FOUR LIPS via direct targeting of core cell cycle genes.";
RL Plant Cell 22:2306-2321(2010).
RN [11]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21105921; DOI=10.1111/j.1365-313x.2010.04364.x;
RA Xie Z., Li D., Wang L., Sack F.D., Grotewold E.;
RT "Role of the stomatal development regulators FLP/MYB88 in abiotic stress
RT responses.";
RL Plant J. 64:731-739(2010).
RN [12]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21772250; DOI=10.1038/emboj.2011.240;
RA Vanneste S., Coppens F., Lee E., Donner T.J., Xie Z., Van Isterdael G.,
RA Dhondt S., De Winter F., De Rybel B., Vuylsteke M., De Veylder L.,
RA Friml J., Inze D., Grotewold E., Scarpella E., Sack F., Beemster G.T.,
RA Beeckman T.;
RT "Developmental regulation of CYCA2s contributes to tissue-specific
RT proliferation in Arabidopsis.";
RL EMBO J. 30:3430-3441(2011).
RN [13]
RP FUNCTION, DISRUPTION PHENOTYPE, AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX PubMed=22915737; DOI=10.1093/jxb/ers209;
RA Makkena S., Lee E., Sack F.D., Lamb R.S.;
RT "The R2R3 MYB transcription factors FOUR LIPS and MYB88 regulate female
RT reproductive development.";
RL J. Exp. Bot. 63:5545-5558(2012).
RN [14]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=24123248; DOI=10.1093/jxb/ert313;
RA Lee E., Liu X., Eglit Y., Sack F.;
RT "FOUR LIPS and MYB88 conditionally restrict the G1/S transition during
RT stomatal formation.";
RL J. Exp. Bot. 64:5207-5219(2013).
RN [15]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=24687979; DOI=10.1093/jxb/eru139;
RA Yang K., Wang H., Xue S., Qu X., Zou J., Le J.;
RT "Requirement for A-type cyclin-dependent kinase and cyclins for the
RT terminal division in the stomatal lineage of Arabidopsis.";
RL J. Exp. Bot. 65:2449-2461(2014).
RN [16]
RP FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, AND INTERACTION WITH
RP RBR1.
RC STRAIN=cv. Columbia;
RX PubMed=24571519; DOI=10.1111/tpj.12489;
RA Lee E., Lucas J.R., Sack F.D.;
RT "Deep functional redundancy between FAMA and FOUR LIPS in stomatal
RT development.";
RL Plant J. 78:555-565(2014).
RN [17]
RP FUNCTION.
RC STRAIN=cv. Columbia;
RX PubMed=24654956; DOI=10.1111/tpj.12516;
RA Lee E., Lucas J.R., Goodrich J., Sack F.D.;
RT "Arabidopsis guard cell integrity involves the epigenetic stabilization of
RT the FLP and FAMA transcription factor genes.";
RL Plant J. 78:566-577(2014).
RN [18]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Columbia GL1;
RX PubMed=26391711; DOI=10.3732/ajb.1500056;
RA Lei Q., Lee E., Keerthisinghe S., Lai L., Li M., Lucas J.R., Wen X.,
RA Ren X., Sack F.D.;
RT "The FOUR LIPS and MYB88 transcription factor genes are widely expressed in
RT Arabidopsis thaliana during development.";
RL Am. J. Bot. 102:1521-1528(2015).
RN [19]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION BY AUXIN.
RX PubMed=26578065; DOI=10.1038/ncomms9821;
RA Chen Q., Liu Y., Maere S., Lee E., Van Isterdael G., Xie Z., Xuan W.,
RA Lucas J., Vassileva V., Kitakura S., Marhavy P., Wabnik K., Geldner N.,
RA Benkova E., Le J., Fukaki H., Grotewold E., Li C., Friml J., Sack F.,
RA Beeckman T., Vanneste S.;
RT "A coherent transcriptional feed-forward motif model for mediating auxin-
RT sensitive PIN3 expression during lateral root development.";
RL Nat. Commun. 6:8821-8821(2015).
RN [20]
RP FUNCTION, DISRUPTION PHENOTYPE, AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX PubMed=26578169; DOI=10.1038/ncomms9822;
RA Wang H.-Z., Yang K.-Z., Zou J.-J., Zhu L.-L., Xie Z.D., Morita M.T.,
RA Tasaka M., Friml J., Grotewold E., Beeckman T., Vanneste S., Sack F.,
RA Le J.;
RT "Transcriptional regulation of PIN genes by FOUR LIPS and MYB88 during
RT Arabidopsis root gravitropism.";
RL Nat. Commun. 6:8822-8822(2015).
CC -!- FUNCTION: Transcription factor that binds to DNA in promoters cis-
CC regulatory element 5'-GGCGCGC-3' of cell cycle genes, including
CC cyclins, cyclin-dependent kinases (CDKs), and components of the pre-
CC replication complex (PubMed:20675570, PubMed:24687979). Binds to DNA in
CC promoters cis-regulatory element 5'-AGCCG-3' of auxin regulated genes
CC (e.g. PIN3 and PIN7) (PubMed:26578169). Together with FAMA and MYB88,
CC ensures that stomata contain just two guard cells (GCs) by enforcing a
CC single symmetric precursor cell division before stomatal maturity
CC (PubMed:24571519). Represses the expression of the mitosis-inducing
CC factors CDKB1-1 and CDKA-1, specifically required for the last guard
CC mother cells (GMC) symmetric divisions in the stomatal pathway
CC (PubMed:20675570, PubMed:24687979). Represses CYCA2-3 in newly formed
CC guard cells (PubMed:21772250). Together with MYB88, regulates stomata
CC spacing by restricting divisions late in the stomatal cell lineage thus
CC limiting the number of GMC divisions (PubMed:11536724, PubMed:9684356,
CC PubMed:16155180, PubMed:24123248). In collaboration with CDKB1-1 and
CC CDKB1-2, restrict the G1/S transition and chloroplast and nuclear
CC number during stomatal formation, and normally maintain fate and
CC developmental progression throughout the stomatal cell lineage
CC (PubMed:24123248). Also involved in the shape regulation of pavement
CC cells (PubMed:9684356). Involved in sensing and/or transducing abiotic
CC stress (e.g. drought and salt), probably via the positive regulation of
CC NAC019 (PubMed:21105921). Regulates female reproduction being required
CC for entry into megasporogenesis, probably via the regulation of cell
CC cycle genes (PubMed:22915737). Promotes histone H3K27me3 marks and
CC represses stem cell gene expression (PubMed:24654956). Required for
CC lateral roots (LRs) initiation via the regulation of PIN3 expression in
CC an auxin-dependent manner (PubMed:26578065). Involved in responses to
CC gravity stimulation in primary roots by regulating the transcription of
CC PIN3 and PIN7 in gravity-sensing cells, thus modulating auxin
CC asymmetric redistribution (PubMed:26578169).
CC {ECO:0000269|PubMed:11536724, ECO:0000269|PubMed:16155180,
CC ECO:0000269|PubMed:20675570, ECO:0000269|PubMed:21105921,
CC ECO:0000269|PubMed:21772250, ECO:0000269|PubMed:22915737,
CC ECO:0000269|PubMed:24123248, ECO:0000269|PubMed:24571519,
CC ECO:0000269|PubMed:24654956, ECO:0000269|PubMed:24687979,
CC ECO:0000269|PubMed:26578065, ECO:0000269|PubMed:26578169,
CC ECO:0000269|PubMed:9684356}.
CC -!- SUBUNIT: Interacts with RBR1. {ECO:0000269|PubMed:24571519}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:20675570}.
CC -!- TISSUE SPECIFICITY: Expressed in all shoot organs with higher levels in
CC leaves, stems, flowers, siliques and floral buds. Also detected in
CC roots tips. {ECO:0000269|PubMed:16155180, ECO:0000269|PubMed:26391711}.
CC -!- DEVELOPMENTAL STAGE: Expressed at the transition to terminal stomatal
CC differentiation, just before and after the symmetric division of
CC stomatal differentiation, being confined to late-stage guard mother
CC cells (GMC) and to young, still differentiating guard cells
CC (PubMed:16155180, PubMed:24571519). Detected in unopened flower buds,
CC at the bases of sepals, petals, and stamens and in the receptacle of
CC carpels, as well as both in style and stigma. Present at strong levels
CC in the placenta within the ovary. Accumulates during ovule development
CC in a dynamic pattern; first observed at high levels in the funiculus
CC once integument outgrowth has begun and persists into later stages.
CC Also expressed in the nucellus of younger ovules, especially in the
CC megaspore mother cell (MMC) and in epidermal cells. Present in
CC integuments, in the endothelial layer and the outer layer of the outer
CC integument, which will form the mucilage-containing seed coat cells
CC (PubMed:22915737). In developing embryos, first detected in cells in
CC the ground tissue meristem at the early heart stage accumulates in the
CC torpedo stage. In mature embryos, expressed in the embryonic hypocotyl
CC and root tip. In seedlings, present first in the lower part of the
CC hypocotyl and in the root tip, and later in petioles of cotyledons,
CC young leaves, and lateral root primordia, near the pericycle. In young
CC plants, strongly expressed in petioles of young leaves and cotyledons,
CC especially in veins, in the basal part of young first leaves and
CC cotyledons, and in root tips of lateral roots. Detected in the phloem,
CC as well as in the cortex of inflorescence stems (PubMed:26391711). In
CC roots, present in the root tip in columella cells, specifically in the
CC lower tier of columella cells, as well as in developing metaxylem
CC (PubMed:26391711, PubMed:26578169). Widely expressed in freshly emerged
CC lateral roots. In elongating lateral roots, confined at high levels
CC transiently in columella cells until differentiation (PubMed:26578169).
CC Expressed at the base of developing flowers, including ovaries. In
CC flowers, detected in ovaries, receptacles, and transiently, in anthers,
CC and, later, in filaments. Also detected in the valve margins and
CC receptacles of siliques and at the joint between the stigma and the
CC style, as well as in the tapetum around pollen grains in maturing
CC anthers (PubMed:26391711). {ECO:0000269|PubMed:16155180,
CC ECO:0000269|PubMed:22915737, ECO:0000269|PubMed:24571519,
CC ECO:0000269|PubMed:26391711, ECO:0000269|PubMed:26578169}.
CC -!- INDUCTION: Strongly induced by auxin in a IAA14/SLR1 and ARF7 dependent
CC manner, especially in xylem pole pericycle cells, lateral roots
CC initiating cells. {ECO:0000269|PubMed:26578065}.
CC -!- DISRUPTION PHENOTYPE: Abnormal stomatal clusters formation composed by
CC two to four adjacent stomata and some unpaired guard cells originating
CC of extra symmetric divisions in cells with an abnormally persistent
CC guard mother cell (GMC) identity (PubMed:11536724, PubMed:9684356,
CC PubMed:16155180, PubMed:20675570). Abnormal stomatal cluster formation
CC is complemented by FAMA (PubMed:24571519). Increased accumulation of
CC CDKB1-1 in single flp-1 and double flp-1 myb88 mutants
CC (PubMed:20675570). Induction of ectopic precursor cell division and
CC delayed stomatal differentiation. End wall thickenings in all first
CC generation GMCs (PubMed:16155180). Stronger accumulation of stomatal
CC clusters separated by jigsaw-shaped pavement cells with wavy anticlinal
CC walls in dorsiventral (e.g. cotyledons, sepals, and anthers) than in
CC cylindrical organs (e.g. stems, flower stalks, and siliques), where
CC pavement cells are rectangular (PubMed:9684356). Double mutants flp-7
CC myb88 and flp-1 myb88 have strong defects in stomata repartition with
CC large stomatal clusters formation (PubMed:16155180). Double mutants
CC flp-1 myb88 have increased susceptibility to drought and high salt
CC (NaCl), as well as increased rates of water loss; these phenotypes are
CC associated with reduced accumulation of many typical abiotic stress
CC gene transcripts. Lower stomatal closure in response to abscisic acid
CC (ABA) treatment (PubMed:21105921). Accumulation of CYCA2-3 in newly
CC formed guard cells in flp-1 myb88 double mutant (PubMed:21772250). The
CC double mutants flp-1 myb88 and flp-7 myb88 treated with oryzalin, a
CC microtubule depolymerizing drug, exhibit round-to-oval-shaped single
CC guard cells (sGCs) associated with increased DNA content due to
CC endoreplication leading to 10C DNA levels. The quadruple mutant flp-1
CC myb88 cdkb1;1 cdkb1;2 has a reduced number of large single guard cells
CC blocked at mitosis, with strongly altered shape and size and
CC characterized by enlarged nucleus due to endomitosis and endocycling,
CC as well as extensive chloroplast replication (PubMed:24123248). The
CC double mutant flp-1 myb88 displays an enhanced stomatal phenotype with
CC more and larger stomatal clusters. Triple mutants cdka;1 flp-1 myb88
CC don't have guard cells stacks but accumulates sGCs. Accumulation of
CC CDKA-1 in the double mutant flp-1 myb88 (PubMed:24687979). Increased
CC number of ovules produced by the placenta but reduced female fertility
CC due to defective meiotic entry and progression, and subsequent altered
CC embryo sac development, thus leading to reduced seed set
CC (PubMed:22915737). Reduced numbers of lateral roots (LRs). The double
CC mutants flp-1 myb88 and flp-7 myb88 lack lateral roots with reduced
CC PIN3 levels (PubMed:26578065). Gravitropic defects in primary roots
CC associated with a delayed auxin asymmetric redistribution due to
CC reduced PIN3 and PIN7 levels (PubMed:26578169).
CC {ECO:0000269|PubMed:11536724, ECO:0000269|PubMed:16155180,
CC ECO:0000269|PubMed:20675570, ECO:0000269|PubMed:21105921,
CC ECO:0000269|PubMed:21772250, ECO:0000269|PubMed:22915737,
CC ECO:0000269|PubMed:24123248, ECO:0000269|PubMed:24571519,
CC ECO:0000269|PubMed:24687979, ECO:0000269|PubMed:26578065,
CC ECO:0000269|PubMed:26578169, ECO:0000269|PubMed:9684356}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF43935.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF371982; AAK54745.2; -; mRNA.
DR EMBL; AC012188; AAF43935.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29150.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29151.1; -; Genomic_DNA.
DR EMBL; BT026126; ABG48482.1; -; mRNA.
DR PIR; H86277; H86277.
DR RefSeq; NP_001077534.1; NM_001084065.3.
DR RefSeq; NP_563948.1; NM_101302.3.
DR AlphaFoldDB; Q94FL6; -.
DR SMR; Q94FL6; -.
DR STRING; 3702.AT1G14350.2; -.
DR PaxDb; Q94FL6; -.
DR PRIDE; Q94FL6; -.
DR EnsemblPlants; AT1G14350.1; AT1G14350.1; AT1G14350.
DR EnsemblPlants; AT1G14350.2; AT1G14350.2; AT1G14350.
DR GeneID; 837997; -.
DR Gramene; AT1G14350.1; AT1G14350.1; AT1G14350.
DR Gramene; AT1G14350.2; AT1G14350.2; AT1G14350.
DR KEGG; ath:AT1G14350; -.
DR Araport; AT1G14350; -.
DR TAIR; locus:2012587; AT1G14350.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_018700_1_0_1; -.
DR InParanoid; Q94FL6; -.
DR OMA; WRQMELY; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q94FL6; -.
DR PRO; PR:Q94FL6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q94FL6; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0009926; P:auxin polar transport; IMP:UniProtKB.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0009553; P:embryo sac development; IMP:TAIR.
DR GO; GO:0010052; P:guard cell differentiation; IGI:UniProtKB.
DR GO; GO:0010235; P:guard mother cell cytokinesis; IMP:UniProtKB.
DR GO; GO:0010444; P:guard mother cell differentiation; IMP:UniProtKB.
DR GO; GO:0090436; P:leaf pavement cell development; IMP:UniProtKB.
DR GO; GO:0009554; P:megasporogenesis; IMP:UniProtKB.
DR GO; GO:0050891; P:multicellular organismal water homeostasis; IMP:UniProtKB.
DR GO; GO:0061087; P:positive regulation of histone H3-K27 methylation; IMP:UniProtKB.
DR GO; GO:1901333; P:positive regulation of lateral root development; IMP:UniProtKB.
DR GO; GO:1901002; P:positive regulation of response to salt stress; IMP:UniProtKB.
DR GO; GO:1902584; P:positive regulation of response to water deprivation; IMP:UniProtKB.
DR GO; GO:0080022; P:primary root development; IMP:UniProtKB.
DR GO; GO:1902806; P:regulation of cell cycle G1/S phase transition; IMP:UniProtKB.
DR GO; GO:0032875; P:regulation of DNA endoreduplication; IMP:UniProtKB.
DR GO; GO:2000037; P:regulation of stomatal complex patterning; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0009737; P:response to abscisic acid; IMP:UniProtKB.
DR GO; GO:0009733; P:response to auxin; IEP:UniProtKB.
DR GO; GO:0009629; P:response to gravity; IMP:UniProtKB.
DR GO; GO:0010376; P:stomatal complex formation; IMP:UniProtKB.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW Auxin signaling pathway; Cell cycle; Developmental protein; DNA-binding;
KW Nucleus; Reference proteome; Repeat; Repressor; Stress response;
KW Transcription; Transcription regulation.
FT CHAIN 1..436
FT /note="Transcription factor MYB124"
FT /id="PRO_0000438722"
FT DOMAIN 20..71
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 72..126
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 48..71
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 99..122
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 8..15
FT /note="Nuclear localization signal 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT MOTIF 151..158
FT /note="Nuclear localization signal 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT MUTAGEN 84
FT /note="E->K: In flp-8; abnormal stomatal clusters
FT formation. Impaired DNA-binding."
FT /evidence="ECO:0000269|PubMed:16155180,
FT ECO:0000269|PubMed:20675570"
SQ SEQUENCE 436 AA; 49600 MW; 3122911BF8545CFD CRC64;
MEDTKKKKKK NINNNQDSKK KERHIVTWSQ EEDVILREQI TLHGTENWAI IASKFKDKST
RQCRRRWYTY LNSDFKRGGW SPEEDMLLCE AQRVFGNRWT EIAKVVSGRT DNAVKNRFTT
LCKKRAKHEA MTKDSNSNTK RMLFLDGIST PRKSENETPI AKKLKRSHIL DLTEISNYGR
AEACVNQQIR SPFSVLARNA TGIDSLEEQN QTSNVNESDG EGMFLKKDDP KVTALMQQAE
LLSSLAQKVN ADNTEQSMEN AWKVLQDFLN KGKENDLFRY GIPDIDFKIE EFKDLIEDLR
SGYEDNQLSW RQPDLHDSPA SSEYSSGSTI MVDQSGDKTQ PFSADTQTEH KQVGEELLVP
KNPDENMPIS GEEKFSSPIQ VTPLFRSLAD GIPSPQFSES ERSFLLKTLG IESSSPCPSA
NPSKPPPCKR VLLHSL
