MY15B_HUMAN
ID MY15B_HUMAN Reviewed; 1530 AA.
AC Q96JP2; A0A0J9YVZ6;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 3.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Unconventional myosin-XVB;
DE AltName: Full=Myosin XVBP;
DE AltName: Full=Unconventional myosin-15B;
GN Name=MYO15B; Synonyms=KIAA1783, MYO15BP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], VARIANT TRP-547, ALTERNATIVE SPLICING, AND LACK
RP OF FUNCTIONAL MOTOR DOMAIN.
RC TISSUE=Kidney, and Stomach;
RX PubMed=11964073; DOI=10.1023/a:1014507705858;
RA Boger E.T., Sellers J.R., Friedman T.B.;
RT "Human myosin XVBP is a transcribed pseudogene.";
RL J. Muscle Res. Cell Motil. 22:477-483(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT TRP-547.
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 8:85-95(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [4]
RP IDENTIFICATION.
RX PubMed=11294886; DOI=10.1091/mbc.12.4.780;
RA Berg J.S., Powell B.C., Cheney R.E.;
RT "A millennial myosin census.";
RL Mol. Biol. Cell 12:780-794(2001).
RN [5]
RP STRUCTURE BY NMR OF 1424-1495.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the SH3 domain of human KIAA1783 protein.";
RL Submitted (OCT-2006) to the PDB data bank.
CC -!- FUNCTION: Unknown, due to the absence of a functional motor domain.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Detected in brain, stomach and kidney.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000305}.
CC -!- CAUTION: Was thought be the product of a pseudogene due to the
CC substitution or deletion of many conserved amino acids in the motor
CC domain. However it has been observed with several high-quality
CC proteotypic peptides in several independent proteomic studies.
CC {ECO:0000305}.
CC -!- CAUTION: Represents an unconventional myosin. This protein should not
CC be confused with the conventional myosin-15 (MYH15). {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB47412.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF418286; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF418287; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF418288; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF418289; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF418290; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF418291; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF418292; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF418293; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AB058686; BAB47412.1; ALT_INIT; mRNA.
DR EMBL; AC087749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF511237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001296171.1; NM_001309242.1.
DR PDB; 2DLP; NMR; -; A=1424-1495.
DR PDBsum; 2DLP; -.
DR AlphaFoldDB; Q96JP2; -.
DR BMRB; Q96JP2; -.
DR SMR; Q96JP2; -.
DR IntAct; Q96JP2; 3.
DR MINT; Q96JP2; -.
DR GlyGen; Q96JP2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96JP2; -.
DR PhosphoSitePlus; Q96JP2; -.
DR BioMuta; MYO15B; -.
DR DMDM; 150384690; -.
DR EPD; Q96JP2; -.
DR jPOST; Q96JP2; -.
DR MassIVE; Q96JP2; -.
DR MaxQB; Q96JP2; -.
DR PaxDb; Q96JP2; -.
DR PeptideAtlas; Q96JP2; -.
DR PRIDE; Q96JP2; -.
DR ProteomicsDB; 76998; -.
DR Antibodypedia; 69409; 2 antibodies from 1 providers.
DR GeneID; 80022; -.
DR KEGG; hsa:80022; -.
DR CTD; 80022; -.
DR GeneCards; MYO15B; -.
DR HGNC; HGNC:14083; MYO15B.
DR HPA; ENSG00000266714; Tissue enhanced (intestine).
DR neXtProt; NX_Q96JP2; -.
DR VEuPathDB; HostDB:ENSG00000266714; -.
DR InParanoid; Q96JP2; -.
DR OrthoDB; 14609at2759; -.
DR PhylomeDB; Q96JP2; -.
DR PathwayCommons; Q96JP2; -.
DR SignaLink; Q96JP2; -.
DR BioGRID-ORCS; 80022; 0 hits in 57 CRISPR screens.
DR ChiTaRS; MYO15B; human.
DR EvolutionaryTrace; Q96JP2; -.
DR GenomeRNAi; 80022; -.
DR Pharos; Q96JP2; Tdark.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q96JP2; protein.
DR Bgee; ENSG00000266714; Expressed in right uterine tube and 149 other tissues.
DR ExpressionAtlas; Q96JP2; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:InterPro.
DR CDD; cd12068; SH3_MYO15B; 1.
DR Gene3D; 1.25.40.530; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR035489; MYO15B_SH3.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome; SH3 domain.
FT CHAIN 1..1530
FT /note="Unconventional myosin-XVB"
FT /id="PRO_0000292047"
FT DOMAIN 1..335
FT /note="Myosin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT DOMAIN 355..384
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 492..643
FT /note="MyTH4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00359"
FT DOMAIN 1422..1483
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 904..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 981..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1489..1508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..94
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..762
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..965
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1017
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1039..1055
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1158
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1203
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 547
FT /note="R -> W (in dbSNP:rs3803728)"
FT /id="VAR_080141"
FT STRAND 1426..1431
FT /evidence="ECO:0007829|PDB:2DLP"
FT STRAND 1436..1440
FT /evidence="ECO:0007829|PDB:2DLP"
FT STRAND 1448..1451
FT /evidence="ECO:0007829|PDB:2DLP"
FT STRAND 1461..1468
FT /evidence="ECO:0007829|PDB:2DLP"
FT STRAND 1470..1474
FT /evidence="ECO:0007829|PDB:2DLP"
FT STRAND 1477..1480
FT /evidence="ECO:0007829|PDB:2DLP"
SQ SEQUENCE 1530 AA; 167088 MW; 5CFC724850DDA4A1 CRC64;
MKEASGVGGG HSPMCPPHCH MPPGPAGEWP GATVQQPRQR APTALLQPDA AGPGGGGVSA
GVAVLGACPS ASEGVLPRPP GRSAPQPPEY PGRPDMAVPG WSAMVRSRLT ATSTSQATDH
TFLQKSHYHH GDHPSYAKPR LPLPVFTVRH YAGTVTYQVH KFLNRNRDQL DPAVVEMLGQ
SQLQLVGSLF QEAEPQSRGG RGRPTLASRF QQALEDLIAR LGRSHVYFIQ CLTPNPGKLP
GLFDVGHVTE QLHQAAILEA VGTRSANFPV RVPFEAFLAS FQALGSEGQE DLSDREKCGA
VLSQVLGAES PLYHLGATKV LLQEQGWQRL EELRDQQRSQ ALVDLHRSFH TCISRQRVLP
RMQARMRGFQ ARKRYLRRRA ALGQLNTILL VAQPLLQRRQ RLQLGRWQGW HSSERALERV
PSMELGRLEI PAELAVMLKT AESHRDALAG SITECLPPEV PARPSLTLPA DIDLFPFSSF
VAIGFQEPSL PRPGQPLAKP LTQLDGDNPQ RALDINKVML RLLGDGSLES WQRQIMGAYL
VRQGQCRPGL RNELFSQLVA QLWQNPDEQQ SQRGWALMAV LLSAFPPLPV LQKPLLKFVS
DQAPRGMAAL CQHKLLGALE QSQLASGATR AHPPTQLEWL AGWRRGRMAL DVFTFSEECY
SAEVESWTTG EQLAGWILQS RGLEAPPRGW SVSLHSRDAW QDLAGCDFVL DLISQTEDLG
DPARPRSYPI TPLGSAEAIP LAPGIQAPSL PPGPPPGPAP TLPSRDHTGE VQRSGSLDGF
LDQIFQPVIS SGLSDLEQSW ALSSRMKGGG AIGPTQQGYP MVYPGMIQMP AYQPGMVPAP
MPMMPAMGTV PAMPAMVVPP QPPLPSLDAG QLAVQQQNFI QQQALILAQQ MTAQAMSLSL
EQQMQQRQQQ ARASEAASQA SPSAVTSKPR KPPTPPEKPQ RDLGSEGGCL RETSEEAEDR
PYQPKSFQQK RNYFQRMGQP QITVRTMKPP AKVHIPQGEA QEEEEEEEEE EEQEEQEVET
RAVPSPPPPP IVKKPLKQGG AKAPKEAEAE PAKETAAKGH GQGPAQGRGT VVRSSDSKPK
RPQPSREIGN IIRMYQSRPG PVPVPVQPSR PPKAFLRKID PKDEALAKLG INGAHSSPPM
LSPSPGKGPP PAVAPRPKAP LQLGPSSSIK EKQGPLLDLF GQKLPIAHTP PPPPAPPLPL
PEDPGTLSAE RRCLTQPVED QGVSTQLLAP SGSVCFSYTG TPWKLFLRKE VFYPRENFSH
PYYLRLLCEQ ILRDTFSESC IRISQNERRK MKDLLGGLEV DLDSLTTTED SVKKRIVVAA
RDNWANYFSR FFPVSGESGS DVQLLAVSHR GLRLLKVTQG PGLRPDQLKI LCSYSFAEVL
GVECRGGSTL ELSLKSEQLV LHTARARAIE ALVELFLNEL KKDSGYVIAL RSYITDNCSL
LSFHRGDLIK LLPVATLEPG WQFGSAGGRS GLFPADIVQP AAAPDFSFSK EQRSGWHKGQ
LSNGEPGLAR WDRASEVRKM GEGQAEARPA
