ID   MY88A_XENLA             Reviewed;         283 AA.
AC   Q9DF60;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Myeloid differentiation primary response protein MyD88-A;
DE   AltName: Full=Toll/IL-1 receptor binding protein MyD88-A;
GN   Name=myd88-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX   PubMed=11025209; DOI=10.1016/s0925-4773(00)00447-0;
RA   Prothmann C., Armstrong N.J., Rupp R.A.;
RT   "The Toll/IL-1 receptor binding protein MyD88 is required for Xenopus axis
RT   formation.";
RL   Mech. Dev. 97:85-92(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein involved in the Toll-like receptor and IL-1
CC       receptor signaling pathway in the innate immune response (By
CC       similarity). Activates expression of target genes in the Spemann
CC       organizer region during early embryonic development. Is required for
CC       normal axis formation. {ECO:0000250, ECO:0000269|PubMed:11025209}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The intermediate domain (ID) is required for the
CC       phosphorylation and activation of IRAK. {ECO:0000250}.
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DR   EMBL; AF294272; AAG10073.1; -; mRNA.
DR   EMBL; BC084238; AAH84238.1; -; mRNA.
DR   RefSeq; NP_001081001.1; NM_001087532.1.
DR   AlphaFoldDB; Q9DF60; -.
DR   SMR; Q9DF60; -.
DR   BioGRID; 98923; 1.
DR   DNASU; 394321; -.
DR   GeneID; 394321; -.
DR   KEGG; xla:394321; -.
DR   CTD; 394321; -.
DR   Xenbase; XB-GENE-865632; myd88.L.
DR   OMA; CTQSWFW; -.
DR   OrthoDB; 890418at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 394321; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070976; F:TIR domain binding; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR   CDD; cd08312; Death_MyD88; 1.
DR   Gene3D; 1.10.533.10; -; 1.
DR   Gene3D; 3.40.50.10140; -; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR034249; MyD88_Death.
DR   InterPro; IPR017281; Myelin_different_resp_MyD88.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR15079; PTHR15079; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   PIRSF; PIRSF037756; MyD88; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   SUPFAM; SSF52200; SSF52200; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Immunity; Inflammatory response; Innate immunity;
KW   Reference proteome.
FT   CHAIN           1..283
FT                   /note="Myeloid differentiation primary response protein
FT                   MyD88-A"
FT                   /id="PRO_0000393145"
FT   DOMAIN          27..105
FT                   /note="Death"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
FT   DOMAIN          147..281
FT                   /note="TIR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
FT   REGION          106..143
FT                   /note="Intermediate domain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   283 AA;  32830 MW;  91FD9FA3D43537DA CRC64;
     MACGSSLDSI DMNSIPLVAL NYTVRHRLCL YLNPDAVVAA DWTRLAEEMG YDYLEIRNFQ
     RYPDSTMKLL EDWEKKCFRA TVGGLLEMLK KMERNDILTD LGPLIEADCM KYLEKKHVPL
     PIQDDKVDSS EQYRITKSDD PYGSMPETFD AFICYCAQDI SFVQEMISRL EQTDYKLKLC
     VFDRDVLPGT CLWSITSELI ENRCRKMVVI ISDDYLDSSD CDFQTKFALS LGPGAREKRL
     IPVKYKPMKR PFPSILRFIT VCDYTNPYTK AWFWDKLAKA LAR