ID   MY88B_XENLA             Reviewed;         283 AA.
AC   Q5FWM2;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Myeloid differentiation primary response protein MyD88-B;
DE   AltName: Full=Toll/IL-1 receptor binding protein MyD88-B;
GN   Name=myd88-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein involved in the Toll-like receptor and IL-1
CC       receptor signaling pathway in the innate immune response. Activates
CC       expression of target genes in the Spemann organizer region during early
CC       embryonic development. Is required for normal axis formation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The intermediate domain (ID) is required for the
CC       phosphorylation and activation of IRAK. {ECO:0000250}.
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DR   EMBL; BC089284; AAH89284.1; -; mRNA.
DR   RefSeq; NP_001089255.1; NM_001095786.1.
DR   AlphaFoldDB; Q5FWM2; -.
DR   SMR; Q5FWM2; -.
DR   DNASU; 734302; -.
DR   GeneID; 734302; -.
DR   KEGG; xla:734302; -.
DR   CTD; 734302; -.
DR   Xenbase; XB-GENE-6251474; myd88.S.
DR   OrthoDB; 890418at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 734302; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070976; F:TIR domain binding; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR   CDD; cd08312; Death_MyD88; 1.
DR   Gene3D; 1.10.533.10; -; 1.
DR   Gene3D; 3.40.50.10140; -; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR034249; MyD88_Death.
DR   InterPro; IPR017281; Myelin_different_resp_MyD88.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR15079; PTHR15079; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PIRSF; PIRSF037756; MyD88; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   SUPFAM; SSF52200; SSF52200; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Immunity; Inflammatory response; Innate immunity;
KW   Reference proteome.
FT   CHAIN           1..283
FT                   /note="Myeloid differentiation primary response protein
FT                   MyD88-B"
FT                   /id="PRO_0000393146"
FT   DOMAIN          27..105
FT                   /note="Death"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
FT   DOMAIN          147..281
FT                   /note="TIR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
FT   REGION          106..143
FT                   /note="Intermediate domain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   283 AA;  32794 MW;  42B8DF7E499F22DA CRC64;
     MACGSSMNSF DMNSIPLVAL NYTVRHRLCL YLNPNAVVAA DWTRLAEEMG YDYLEIRNFD
     RYPDSTMKLL EDWQKKCFRA TVGGLLEMLK KMERNDILTD LAPLIEADCK KYLEKKHGPL
     PLQDDNVDSS EQYRITKSDD PYGSMPETFD AFICCCAQDI LFVQEMISRL EQTDYKLKLC
     VFDRDVLPGT CLWSITSELI ENRCRKMVVI ISDDYLDSSE CDFQTKFALS LGPGAREKRL
     IPVKYKPMKR PFPSILRFIT LCDNTNPYTK VWFWDKLAKA LAR