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MY9AB_DANRE
ID   MY9AB_DANRE             Reviewed;        2286 AA.
AC   E7F3F0;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2018, sequence version 3.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Unconventional myosin-IXAb {ECO:0000250|UniProtKB:B2RTY4};
DE   AltName: Full=Myosin IXAb {ECO:0000312|ZFIN:ZDB-GENE-080424-6};
GN   Name=myo9ab {ECO:0000312|ZFIN:ZDB-GENE-080424-6};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=27259756; DOI=10.1093/brain/aww130;
RA   O'Connor E., Toepf A., Mueller J.S., Cox D., Evangelista T., Colomer J.,
RA   Abicht A., Senderek J., Hasselmann O., Yaramis A., Laval S.H.,
RA   Lochmueller H.;
RT   "Identification of mutations in the MYO9A gene in patients with congenital
RT   myasthenic syndrome.";
RL   Brain 139:2143-2153(2016).
CC   -!- FUNCTION: Myosins are actin-based motor molecules with ATPase activity.
CC       Unconventional myosins serve in intracellular movements. Regulates Rho
CC       by stimulating it's GTPase activity in neurons (By similarity).
CC       Required for the regulation of neurite branching and motor neuron axon
CC       guidance (PubMed:27259756). {ECO:0000250|UniProtKB:Q9Z1N3,
CC       ECO:0000269|PubMed:27259756}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q9Z1N3}.
CC       Synapse {ECO:0000250|UniProtKB:Q8C170}. Cell projection, growth cone
CC       {ECO:0000250|UniProtKB:Q8C170}. Note=Localized in the cytoplasm of cell
CC       bodies, dendrites and axons with occasional hints of an enrichment near
CC       the plasma membrane. Localized at the neuromuscular junction.
CC       {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino-induced knockdown affects tail
CC       morphology, and causes cardiac edema and abnormal swimming in response
CC       to tactile stimulation. Morphants show aberrant axons, either short or
CC       over-extended, with some axons appearing to branch to the adjacent
CC       myotome. {ECO:0000269|PubMed:27259756}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Myosin family. {ECO:0000255|PROSITE-ProRule:PRU00782}.
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DR   EMBL; CABZ01074925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01074926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01074927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01074928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01074929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01074930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU633744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; E7F3F0; -.
DR   SMR; E7F3F0; -.
DR   STRING; 7955.ENSDARP00000032580; -.
DR   Ensembl; ENSDART00000028997; ENSDARP00000032580; ENSDARG00000073843.
DR   ZFIN; ZDB-GENE-080424-6; myo9ab.
DR   eggNOG; KOG1453; Eukaryota.
DR   eggNOG; KOG4229; Eukaryota.
DR   GeneTree; ENSGT00940000154905; -.
DR   HOGENOM; CLU_000192_2_1_1; -.
DR   InParanoid; E7F3F0; -.
DR   TreeFam; TF319651; -.
DR   PRO; PR:E7F3F0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 25.
DR   Bgee; ENSDARG00000073843; Expressed in brain and 20 other tissues.
DR   ExpressionAtlas; E7F3F0; baseline and differential.
DR   GO; GO:0005884; C:actin filament; IBA:GO_Central.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0044295; C:axonal growth cone; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR   GO; GO:0061564; P:axon development; IGI:ZFIN.
DR   GO; GO:0048675; P:axon extension; IGI:ZFIN.
DR   GO; GO:0045198; P:establishment of epithelial cell apical/basal polarity; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0007626; P:locomotory behavior; IGI:ZFIN.
DR   GO; GO:0098529; P:neuromuscular junction development, skeletal muscle fiber; IGI:ZFIN.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IEA:InterPro.
DR   GO; GO:0036269; P:swimming behavior; IGI:ZFIN.
DR   CDD; cd00029; C1; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 3.40.850.10; -; 2.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR028558; MYO9A.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR46184:SF3; PTHR46184:SF3; 3.
DR   Pfam; PF00612; IQ; 2.
DR   Pfam; PF00063; Myosin_head; 2.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00015; IQ; 4.
DR   SMART; SM00242; MYSc; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   SUPFAM; SSF57889; SSF57889; 1.
DR   PROSITE; PS50096; IQ; 3.
DR   PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   3: Inferred from homology;
KW   Actin-binding; ATP-binding; Cell projection; Coiled coil; Cytoplasm;
KW   Membrane; Metal-binding; Motor protein; Myosin; Nucleotide-binding;
KW   Phosphoprotein; Reference proteome; Synapse; Transmembrane;
KW   Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..2286
FT                   /note="Unconventional myosin-IXAb"
FT                   /id="PRO_0000447240"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          16..114
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT   DOMAIN          148..971
FT                   /note="Myosin motor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT   DOMAIN          976..996
FT                   /note="IQ 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1025..1054
FT                   /note="IQ 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1066..1095
FT                   /note="IQ 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1089..1118
FT                   /note="IQ 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1823..2011
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT   ZN_FING         1759..1808
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00226"
FT   REGION          853..875
FT                   /note="Actin-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT   REGION          976..1113
FT                   /note="Neck or regulatory domain"
FT                   /evidence="ECO:0000250|UniProtKB:B2RTY4"
FT   REGION          1114..2254
FT                   /note="Tail"
FT                   /evidence="ECO:0000250|UniProtKB:B2RTY4"
FT   REGION          1118..1279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1308..1341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1455..1588
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1732..1754
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2032..2087
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2113..2286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          2080..2107
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1133..1178
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1185..1217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1308..1323
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1539..1588
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2033..2048
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2160..2175
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2179..2215
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2239..2271
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         242..249
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   2286 AA;  262083 MW;  DF9F1A1A2DEF882C CRC64;
     IMSCHDVGGR RRFEDSEFTL RVYPGSLSES TIYCPVSARK VTTAAEVIER VIERLQLDRT
     RLYVLAEVKE FGGEEWILNP SDCPAQRMML WPRMALENRL LGEDYRFLLR EKNLDGSIHY
     GSLQMWLRVT EERRRMVERG LLPQPPAAQF VADLCSLPDL NEHTMLENLR GRFRQENIYT
     YVGSILIAVN PFKFLPIYNP KYVKMYDKHR LGQLEPHIFA VADAAYHAML QRHRNQCIVI
     SGESGSGKTQ STNFLIHHLT ALSQKGFASG VEQIILGAGP VLEAFGNAKT AHNNNSSRFG
     KFIQVNYQES GTVRGAYVEK YLLEKSRLVY QEHNERCSCV NIFSKLVCHE LKVCVCMCVQ
     DCFSVEAEDL KHDFERLQLA MEMVGFLPTT RKQIFSLLSA ILHLGNIRYK KKTFRDDSID
     ICNPEVLPIV SELLEVKEEM LFEALTTRKT VTVGERLIVP YKLAEVRKGT SHQLIQTFRT
     SHSLLHQRYF HIHTSPTRIL SIGVLDIFGF EDYENNSFEQ FCINFANETL QHYFNQHVFK
     LEQEEYRSEG INWHMIDYID NTACINLISK KPTALLHLLD EECNFPQASN QTLLDKFKRQ
     HEGNAYMEFP AVMEPAFIIR HYAGKVKYSV KDFREKNTDH LRPDIVSLLK SSRKAFICGL
     MGLDPVASFR WAVIRAFFRA LVAFRHAGLQ HRDNRSSSDV HLQPQKSVDS FSFLHHPVHQ
     RSLEILQRCK DDRYNSCVSR RSPRTPLSDL QGANTFSSNG RGWRSERVSS FAHEDEGIFV
     NSVNNRLLER AQGILMRNKN YKPKPSLPKH LLDVKSLKYL SSLTLHDRIT KSLLHLHKKK
     KPPSISAQFN VSLNKLMETL GQSEPYFVKC IRSNAEKLPL RFNDALVLRQ LRYTGMLETV
     RIRQSGYSVK YSFKDFAHHF HVLLPAGFSA SQMGIREFLR SADLEPSGYQ VGRSMVFLHE
     RLRQRLQDEL HQEVLRRIVC LQRSFRTQRD RKHFCRQRRA ARLIQRWWRS CISQADGSVC
     ALELQQGAAL RLQAVWRGFR ARRLYLQQRR AVLIIQRCWR RVLNTRNTAA TLIQAVWRTR
     THRRSFLQQR RAAVTLQAAC RGQQSRQRCR ILREQQCREQ SKHPSTVTKS LHQNTEEAEK
     LEEVWEKQTT DPPPKAVDDS TLKSRNKRES RRQRELEQAT FSLELLKVRS GSNTEDAQIP
     PSKHHPPHQA STDSQESFEL LENEDSASAK LELSKSEPME VNQTSPAASF KPHFYIPDED
     GSPINSAPQT PNRAKQIREK KESVVVIISM QKENPVDRSS LQTLEAQDVP LSNGESASDC
     SIIPEPRTNH ELDTGSSFSV SSKPLQLDLR SAASNEEPSE PKADVQKKFV SQSISISMKE
     TAANVAFPPK RSRLTFSKSD KDLVNQERSL AIQREAGFRS LKNRDVTRAG CKKKARMART
     RSDFLSRACS TEADCEEDED DEYEDTPVLS CTRPPHSPSS PDIDCVFHSD SEMSSQKEQK
     RIQKTMSSGD LGKMDSLRKS MSQTDSRVRG KMRFWSKSKH GDKKISSRGR SADSELTDRR
     NDSPPGSPEH AGVSERRRDS KENREPMLGM MSMKRRRSLK ISSVSLESTA WQNDALHILT
     STADYRSMND FLMKKISDLD AEDGQKDTAV DVVFKKALKE FRLNIFNSYS TALAMDDGRS
     IRYKDLYALF EHILEKSMRL EQRDWSESPV KVWVNTFKVF LDEFMTEYKP MDGTISKAPK
     PERKKRRKKE SDTVEEHMGH IFKSTQYSIP TYCEFCSSLI WMMDKACVCK LCRYACHKKC
     CLRMTTKCSK KFDPELSSRQ FGVELSRLTS DERSVPLVVE KLINYIEMHG LYTEGIYRKS
     GSTNKIKELK QGLDTDANSV NLDDYNIHVI ASVLKQWLRD LPNPLMTFEL YEEFLRAMGL
     QDKREVVQGV YSIIDQLSRT HLNTLERLIF HLVRISFQEE TNRMSANALA IVFAPCILRC
     PDTTDPLQSV RDISKTTACV ELIICEQMRK YKARLKDINT LEFAENKAKS RLTHIRRSMG
     KSRARKSGHH TPSPPLSPRA SEREEPVDEG AEPVLSEQQQ AAMQQEEKVL TQQIENLQKE
     KEELTYEMLA LEPRASDDEM LESEASIGTA DSSENLMESE GAASDPWEKS PGAVSASRWR
     KSESKSRRCL RRQPESLDSV DSAVASLSSV SSTPHYRFRS SSSGPLFSSS SPTGDLHILP
     DPESCEQASL SARCASSSEK TRPRPRANRS CPPKPREPGD TGGRRREHEF GSSQPLVLYG
     SNEFMV
 
 
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