MYB10_ARATH
ID MYB10_ARATH Reviewed; 239 AA.
AC Q9LTV4; Q9ZTF3;
DT 22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Transcription factor MYB10 {ECO:0000303|PubMed:9839469};
DE AltName: Full=Myb-related protein 10 {ECO:0000303|PubMed:9839469};
DE Short=AtMYB10 {ECO:0000303|PubMed:9839469};
GN Name=MYB10 {ECO:0000312|EMBL:AEE75249.1};
GN OrderedLocusNames=At3g12820 {ECO:0000312|Araport:AT3G12820};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: A genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 71-239, TISSUE SPECIFICITY, INDUCTION BY
RP ETHYLENE AND DARKNESS, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [6]
RP INDUCTION BY POTASSIUM STARVATION.
RX PubMed=15489280; DOI=10.1104/pp.104.046672;
RA Hampton C.R., Bowen H.C., Broadley M.R., Hammond J.P., Mead A., Payne K.A.,
RA Pritchard J., White P.J.;
RT "Cesium toxicity in Arabidopsis.";
RL Plant Physiol. 136:3824-3837(2004).
RN [7]
RP GENE FAMILY.
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
RN [8]
RP INDUCTION BY ZINC AND CADMIUM.
RC STRAIN=cv. Columbia;
RX PubMed=18088336; DOI=10.1111/j.1365-3040.2007.01764.x;
RA van de Mortel J.E., Schat H., Moerland P.D., Ver Loren van Themaat E.,
RA van der Ent S., Blankestijn H., Ghandilyan A., Tsiatsiani S., Aarts M.G.M.;
RT "Expression differences for genes involved in lignin, glutathione and
RT sulphate metabolism in response to cadmium in Arabidopsis thaliana and the
RT related Zn/Cd-hyperaccumulator Thlaspi caerulescens.";
RL Plant Cell Environ. 31:301-324(2008).
RN [9]
RP FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY IRON STARVATION, AND
RP SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=24278034; DOI=10.1371/journal.pgen.1003953;
RA Palmer C.M., Hindt M.N., Schmidt H., Clemens S., Guerinot M.L.;
RT "MYB10 and MYB72 are required for growth under iron-limiting conditions.";
RL PLoS Genet. 9:E1003953-E1003953(2013).
CC -!- FUNCTION: Involved in metal ions homeostasis, including iron ions (Fe)
CC acquisition, via the regulation of NAS4 and NAS2 genes expression.
CC Necessary for plant survival in alkaline soil where iron availability
CC is greatly restricted. Triggers tolerance to nickel (Ni) and zinc (Zn)
CC ions. {ECO:0000269|PubMed:24278034}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:24278034}.
CC -!- TISSUE SPECIFICITY: Expressed in cauline leaves and siliques.
CC {ECO:0000269|PubMed:9839469}.
CC -!- INDUCTION: Accumulates strongly in the root stele and in the outer
CC layers of the lateral roots when exposed to iron (Fe)-deficient
CC conditions (PubMed:24278034). Slightly induced by ethylene and by
CC darkness conditions (PubMed:9839469). Accumulates upon potassium (K)
CC depletion (PubMed:15489280). Induced by zinc (Zn) and cadmium (Cd) ions
CC (PubMed:18088336). {ECO:0000269|PubMed:15489280,
CC ECO:0000269|PubMed:18088336, ECO:0000269|PubMed:24278034,
CC ECO:0000269|PubMed:9839469}.
CC -!- DISRUPTION PHENOTYPE: Plants lacking myb10 and myb72 fail to induce
CC transcript accumulation of the nicotianamine synthase genes NAS4 and
CC NAS2 in iron ions (Fe) deficiency, and exhibits nickel (Ni) and zinc
CC (Zn) sensitivity. {ECO:0000269|PubMed:24278034}.
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DR EMBL; AY519586; AAS10056.1; -; mRNA.
DR EMBL; AB024033; BAB02426.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75249.1; -; Genomic_DNA.
DR EMBL; AF062862; AAC83584.1; -; mRNA.
DR PIR; T51634; T51634.
DR RefSeq; NP_187888.1; NM_112118.3.
DR AlphaFoldDB; Q9LTV4; -.
DR SMR; Q9LTV4; -.
DR IntAct; Q9LTV4; 1.
DR STRING; 3702.AT3G12820.1; -.
DR PaxDb; Q9LTV4; -.
DR PRIDE; Q9LTV4; -.
DR EnsemblPlants; AT3G12820.1; AT3G12820.1; AT3G12820.
DR GeneID; 820464; -.
DR Gramene; AT3G12820.1; AT3G12820.1; AT3G12820.
DR KEGG; ath:AT3G12820; -.
DR Araport; AT3G12820; -.
DR TAIR; locus:2087690; AT3G12820.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_25_6_1; -.
DR InParanoid; Q9LTV4; -.
DR OMA; WSHEESE; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q9LTV4; -.
DR PRO; PR:Q9LTV4; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LTV4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0010468; P:regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0009646; P:response to absence of light; IEP:UniProtKB.
DR GO; GO:0046686; P:response to cadmium ion; ISS:UniProtKB.
DR GO; GO:0009723; P:response to ethylene; IEP:UniProtKB.
DR GO; GO:1990641; P:response to iron ion starvation; IMP:UniProtKB.
DR GO; GO:0010043; P:response to zinc ion; ISS:UniProtKB.
DR GO; GO:1990532; P:stress response to nickel ion; IMP:UniProtKB.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..239
FT /note="Transcription factor MYB10"
FT /id="PRO_0000442348"
FT DOMAIN 11..63
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 64..118
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 39..63
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 91..114
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
SQ SEQUENCE 239 AA; 27317 MW; 014B4A1435C32D3B CRC64;
MGNRRAPCCD KSQVKRGPWS DEESERLRSF ILKNGHQNWR SLPKLAGLMR CGKSCRLRWI
NYLRPGLKRG NFTKEEEDTI IHLHQAYGNK WSKIASNFPG RTDNEIKNVW NTHLKKRLVK
RSISSSSSDV TNHSVSSTSS SSSSISSVLQ DVIIKSERPN QEEEFGEILV EQMACGFEVD
APQSLECLFD DSQVPPPISK PDSLQTHGKS SDHEFWSRLI EPGFDDYNEW LIFLDNQTC
