MYB11_ARATH
ID MYB11_ARATH Reviewed; 343 AA.
AC Q9LZK4; Q6R078; Q9ZTF2;
DT 15-FEB-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Transcription factor MYB11 {ECO:0000303|PubMed:9839469};
DE AltName: Full=Myb-related protein 11 {ECO:0000303|PubMed:9839469};
DE Short=AtMYB11 {ECO:0000303|PubMed:9839469};
DE AltName: Full=Protein PRODUCTION OF FLAVONOL GLYCOSIDES 2 {ECO:0000303|PubMed:17419845};
GN Name=MYB11 {ECO:0000303|PubMed:9839469};
GN Synonyms=PFG2 {ECO:0000303|PubMed:17419845};
GN OrderedLocusNames=At3g62610 {ECO:0000312|Araport:AT3G62610};
GN ORFNames=F26K9.40 {ECO:0000312|EMBL:CAB83111.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: A genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 72-343, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [6]
RP GENE FAMILY.
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
RN [7]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=cv. Columbia;
RX PubMed=17419845; DOI=10.1111/j.1365-313x.2007.03078.x;
RA Stracke R., Ishihara H., Huep G., Barsch A., Mehrtens F., Niehaus K.,
RA Weisshaar B.;
RT "Differential regulation of closely related R2R3-MYB transcription factors
RT controls flavonol accumulation in different parts of the Arabidopsis
RT thaliana seedling.";
RL Plant J. 50:660-677(2007).
RN [8]
RP FUNCTION, DISRUPTION PHENOTYPE, AND DEVELOPMENTAL STAGE.
RX PubMed=18359753; DOI=10.1093/jxb/ern027;
RA Petroni K., Falasca G., Calvenzani V., Allegra D., Stolfi C., Fabrizi L.,
RA Altamura M.M., Tonelli C.;
RT "The AtMYB11 gene from Arabidopsis is expressed in meristematic cells and
RT modulates growth in planta and organogenesis in vitro.";
RL J. Exp. Bot. 59:1201-1213(2008).
RN [9]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=20731781; DOI=10.1111/j.1469-8137.2010.03421.x;
RA Stracke R., Jahns O., Keck M., Tohge T., Niehaus K., Fernie A.R.,
RA Weisshaar B.;
RT "Analysis of PRODUCTION OF FLAVONOL GLYCOSIDES-dependent flavonol glycoside
RT accumulation in Arabidopsis thaliana plants reveals MYB11-, MYB12- and
RT MYB111-independent flavonol glycoside accumulation.";
RL New Phytol. 188:985-1000(2010).
RN [10]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=19895401; DOI=10.1111/j.1365-3040.2009.02061.x;
RA Stracke R., Favory J.-J., Gruber H., Bartelniewoehner L., Bartels S.,
RA Binkert M., Funk M., Weisshaar B., Ulm R.;
RT "The Arabidopsis bZIP transcription factor HY5 regulates expression of the
RT PFG1/MYB12 gene in response to light and ultraviolet-B radiation.";
RL Plant Cell Environ. 33:88-103(2010).
RN [11]
RP BIOTECHNOLOGY.
RC STRAIN=cv. Columbia;
RX PubMed=25981047; DOI=10.1007/s00299-015-1803-z;
RA Pandey A., Misra P., Trivedi P.K.;
RT "Constitutive expression of Arabidopsis MYB transcription factor, AtMYB11,
RT in tobacco modulates flavonoid biosynthesis in favor of flavonol
RT accumulation.";
RL Plant Cell Rep. 34:1515-1528(2015).
CC -!- FUNCTION: Modulates overall growth by reducing the proliferation
CC activity of meristematic cells and delaying development
CC (PubMed:18359753). Flavonol-specific transcription activator involved
CC in the regulation of several genes of flavonoid biosynthesis. Activates
CC the expression of CHS, CHI, F3H and FLS1 (PubMed:17419845,
CC PubMed:20731781). Confers tolerance to UV-B (PubMed:19895401).
CC {ECO:0000269|PubMed:17419845, ECO:0000269|PubMed:18359753,
CC ECO:0000269|PubMed:19895401, ECO:0000269|PubMed:20731781}.
CC -!- INTERACTION:
CC Q9LZK4; Q9M1Z5: MPK10; NbExp=3; IntAct=EBI-15217402, EBI-2358527;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- TISSUE SPECIFICITY: Expressed in seedlings, roots, cotyledons, leaves
CC and apical meristems. {ECO:0000269|PubMed:17419845}.
CC -!- DEVELOPMENTAL STAGE: Expressed in root and shoot meristems and also in
CC young still meristematic leaf and flower primordia (PubMed:18359753).
CC In seedlings, accumulates ubiquitously at low levels. Expressed in
CC shoot apical meristem (SAM), primary leaves, apex of cotyledons, and at
CC the hypocotyl-root transition. In roots, present at the origin of
CC lateral roots and the root tip, as well as in the vascular tissue of
CC lateral roots (PubMed:17419845). {ECO:0000269|PubMed:17419845,
CC ECO:0000269|PubMed:18359753}.
CC -!- DISRUPTION PHENOTYPE: Accelerated germination, faster hypocotyl and
CC primary root elongation, more lateral and adventitious roots formation,
CC faster development of the inflorescence, and more lateral
CC inflorescences initiation and fruits (PubMed:18359753). The double
CC mutant myb11 myb111 and triple mutant myb11 myb12 myb111 accumulate
CC less flavonols in roots, leaves, stems, inflorescence, and siliques.
CC The double mutant myb11 myb12 is specifically altered in flavonols
CC content of siliques (PubMed:20731781). The triple mutant myb11 myb12
CC myb111 is impaired in flavonols biosynthesis and exhibits a reduced UV-
CC B tolerance (PubMed:17419845, PubMed:19895401).
CC {ECO:0000269|PubMed:17419845, ECO:0000269|PubMed:18359753,
CC ECO:0000269|PubMed:19895401, ECO:0000269|PubMed:20731781}.
CC -!- BIOTECHNOLOGY: Promotes flavonoid biosynthesis when expressed in
CC tobacco (Nicotiana tabacum) through up-regulation of the biosynthetic
CC genes. {ECO:0000269|PubMed:25981047}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC83585.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY519602; AAS10072.1; -; mRNA.
DR EMBL; AL162651; CAB83111.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE80369.1; -; Genomic_DNA.
DR EMBL; AF062863; AAC83585.1; ALT_TERM; mRNA.
DR PIR; T48050; T48050.
DR PIR; T51635; T51635.
DR RefSeq; NP_191820.1; NM_116126.3.
DR AlphaFoldDB; Q9LZK4; -.
DR SMR; Q9LZK4; -.
DR IntAct; Q9LZK4; 5.
DR STRING; 3702.AT3G62610.1; -.
DR PaxDb; Q9LZK4; -.
DR PRIDE; Q9LZK4; -.
DR EnsemblPlants; AT3G62610.1; AT3G62610.1; AT3G62610.
DR GeneID; 825435; -.
DR Gramene; AT3G62610.1; AT3G62610.1; AT3G62610.
DR KEGG; ath:AT3G62610; -.
DR Araport; AT3G62610; -.
DR TAIR; locus:2081735; AT3G62610.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_6_3_1; -.
DR InParanoid; Q9LZK4; -.
DR OMA; WDFVWRE; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q9LZK4; -.
DR PRO; PR:Q9LZK4; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LZK4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IPI:TAIR.
DR GO; GO:0051555; P:flavonol biosynthetic process; IMP:TAIR.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:UniProtKB.
DR GO; GO:0048640; P:negative regulation of developmental growth; IMP:UniProtKB.
DR GO; GO:1900386; P:positive regulation of flavonol biosynthetic process; IMP:UniProtKB.
DR GO; GO:0009416; P:response to light stimulus; IEP:UniProtKB.
DR GO; GO:0010224; P:response to UV-B; IMP:UniProtKB.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation.
FT CHAIN 1..343
FT /note="Transcription factor MYB11"
FT /id="PRO_0000438914"
FT DOMAIN 9..61
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 62..116
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 37..61
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 89..112
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 126..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 260
FT /note="S -> F (in Ref. 1; AAS10072)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 343 AA; 38314 MW; CFB9C0999E94F130 CRC64;
MGRAPCCEKV GIKKGRWTAE EDRTLSDYIQ SNGEGSWRSL PKNAGLKRCG KSCRLRWINY
LRSDIKRGNI TPEEEDVIVK LHSTLGTRWS TIASNLPGRT DNEIKNYWNS HLSRKLHGYF
RKPTVANTVE NAPPPPKRRP GRTSRSAMKP KFILNPKNHK TPNSFKANKS DIVLPTTTIE
NGEGDKEDAL MVLSSSSLSG AEEPGLGPCG YGDDGDCNPS INGDDGALCL NDDIFDSCFL
LDDSHAVHVS SCESNNVKNS EPYGGMSVGH KNIETMADDF VDWDFVWREG QTLWDEKEDL
DSVLSRLLDG EEMESEIRQR DSNDFGEPLD IDEENKMAAW LLS
