MYB16_ARATH
ID MYB16_ARATH Reviewed; 326 AA.
AC Q9LXF1;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Transcription factor MYB16 {ECO:0000305};
DE AltName: Full=Myb-related protein 16 {ECO:0000303|PubMed:11597504};
DE Short=AtMYB16 {ECO:0000303|PubMed:11597504};
DE AltName: Full=Protein MIXTA homolog {ECO:0000303|PubMed:17376813};
DE Short=AtMIXTA {ECO:0000303|PubMed:17376813};
GN Name=MYB16 {ECO:0000303|PubMed:11597504};
GN OrderedLocusNames=At5g15310 {ECO:0000312|Araport:AT5G15310};
GN ORFNames=F8M21_200 {ECO:0000312|EMBL:CAB89341.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [7]
RP FUNCTION.
RX PubMed=17376813; DOI=10.1242/dev.02836;
RA Baumann K., Perez-Rodriguez M., Bradley D., Venail J., Bailey P., Jin H.,
RA Koes R., Roberts K., Martin C.;
RT "Control of cell and petal morphogenesis by R2R3 MYB transcription
RT factors.";
RL Development 134:1691-1701(2007).
RN [8]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=23709630; DOI=10.1105/tpc.113.110783;
RA Oshima Y., Shikata M., Koyama T., Ohtsubo N., Mitsuda N., Ohme-Takagi M.;
RT "MIXTA-like transcription factors and WAX INDUCER1/SHINE1 coordinately
RT regulate cuticle development in Arabidopsis and Torenia fournieri.";
RL Plant Cell 25:1609-1624(2013).
RN [9]
RP FUNCTION.
RX PubMed=24169067; DOI=10.4161/psb.26826;
RA Oshima Y., Mitsuda N.;
RT "The MIXTA-like transcription factor MYB16 is a major regulator of cuticle
RT formation in vegetative organs.";
RL Plant Signal. Behav. 8:E26826-E26826(2013).
CC -!- FUNCTION: Involved in the control of epidermal cell morphogenesis in
CC petals. Promotes unidirectional cell expansion once outgrowth has been
CC initiated (PubMed:17376813). Coordinately with WIN1/SHN1, participates
CC in the regulation of cuticle biosynthesis and wax accumulation in
CC reproductive organs and trichomes. Functions in cuticle nanoridge
CC formation in petals and stamens, and in morphogenesis of petal conical
CC cells and trichomes (PubMed:23709630). Functions as a major regulator
CC of cuticle formation in vegetative organs by regulating the cuticle
CC biosynthesis genes CYP86A8/LCR and CER1 (PubMed:24169067).
CC {ECO:0000269|PubMed:17376813, ECO:0000269|PubMed:23709630,
CC ECO:0000269|PubMed:24169067}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- TISSUE SPECIFICITY: Expressed in trichomes, epidermis and mesophyll
CC cells of young leaves, stems, petals, sepals, carpels and stamens.
CC {ECO:0000269|PubMed:23709630}.
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DR EMBL; AY519624; AAS10094.1; -; mRNA.
DR EMBL; AL353993; CAB89341.1; -; Genomic_DNA.
DR EMBL; CP002688; AED92146.1; -; Genomic_DNA.
DR EMBL; AF370613; AAK43932.1; -; mRNA.
DR EMBL; BT028929; ABI49476.1; -; mRNA.
DR EMBL; AK228474; BAF00400.1; -; mRNA.
DR PIR; T49966; T49966.
DR RefSeq; NP_197035.1; NM_121535.4.
DR AlphaFoldDB; Q9LXF1; -.
DR SMR; Q9LXF1; -.
DR STRING; 3702.AT5G15310.1; -.
DR PaxDb; Q9LXF1; -.
DR PRIDE; Q9LXF1; -.
DR ProteomicsDB; 251377; -.
DR EnsemblPlants; AT5G15310.1; AT5G15310.1; AT5G15310.
DR GeneID; 831383; -.
DR Gramene; AT5G15310.1; AT5G15310.1; AT5G15310.
DR KEGG; ath:AT5G15310; -.
DR Araport; AT5G15310; -.
DR TAIR; locus:2150891; AT5G15310.
DR eggNOG; KOG0048; Eukaryota.
DR InParanoid; Q9LXF1; -.
DR OMA; IDEHGYG; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q9LXF1; -.
DR PRO; PR:Q9LXF1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LXF1; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000902; P:cell morphogenesis; IMP:UniProtKB.
DR GO; GO:0035017; P:cuticle pattern formation; IMP:UniProtKB.
DR GO; GO:1901957; P:regulation of cutin biosynthetic process; IMP:UniProtKB.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation.
FT CHAIN 1..326
FT /note="Transcription factor MYB16"
FT /id="PRO_0000439925"
FT DOMAIN 9..61
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 62..116
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 37..61
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 89..112
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 197..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 326 AA; 36943 MW; 7E19D2B0F252C837 CRC64;
MGRSPCCDKL GLKKGPWTPE EDQKLLAYIE EHGHGSWRSL PEKAGLHRCG KSCRLRWTNY
LRPDIKRGKF NLQEEQTIIQ LHALLGNRWS AIATHLPKRT DNEIKNYWNT HLKKRLVKMG
IDPVTHKPKN ETPLSSLGLS KNAAILSHTA QWESARLEAE ARLARESKLL HLQHYQTKTS
SQPHHHHGFT HKSLLPNWTT KPHEDQQQLE SPTSTVSFSE MKESIPAKIE FVGSSTGVTL
MKEPEHDWIN STMHEFETTQ MGEGIEEGFT GLLLGGDSID RSFSGDKNET AGESSGGDCN
YYEDNKNYLD SIFNFVDPSP SDSPMF
