MYB17_ARATH
ID MYB17_ARATH Reviewed; 299 AA.
AC Q9M2D9; Q9ZTF1;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Transcription factor MYB17 {ECO:0000305};
DE AltName: Full=Myb-related protein 17 {ECO:0000303|PubMed:11597504};
DE Short=AtMYB17 {ECO:0000303|PubMed:11597504};
DE AltName: Full=Protein LATE MERISTEM IDENTITY 2;
GN Name=MYB17 {ECO:0000303|PubMed:11597504};
GN Synonyms=LMI2 {ECO:0000303|PubMed:21750030};
GN OrderedLocusNames=At3g61250 {ECO:0000312|Araport:AT3G61250};
GN ORFNames=T20K12.150 {ECO:0000312|EMBL:CAB71055.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA De Los Reyes C., Quan R., Chen H., Bautista V.R., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 76-299.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=19232308; DOI=10.1016/s1673-8527(08)60096-x;
RA Zhang Y., Cao G., Qu L.J., Gu H.;
RT "Characterization of Arabidopsis MYB transcription factor gene AtMYB17 and
RT its possible regulation by LEAFY and AGL15.";
RL J. Genet. Genomics 36:99-107(2009).
RN [8]
RP FUNCTION, INTERACTION WITH LFY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=21750030; DOI=10.1242/dev.063073;
RA Pastore J.J., Limpuangthip A., Yamaguchi N., Wu M.F., Sang Y., Han S.K.,
RA Malaspina L., Chavdaroff N., Yamaguchi A., Wagner D.;
RT "LATE MERISTEM IDENTITY2 acts together with LEAFY to activate APETALA1.";
RL Development 138:3189-3198(2011).
CC -!- FUNCTION: Transcription factor that may play a role in flower
CC development by repressing ANT (PubMed:19232308). Regulates the
CC transition of meristem identity from vegetative growth to flowering.
CC Acts downstream of LFY and upstream of AP1. Directly activates AP1 to
CC promote floral fate. Together with LFY and AP1 may constitute a
CC regulatory network that contributes to an abrupt and robust meristem
CC identity transition (PubMed:21750030). {ECO:0000269|PubMed:19232308,
CC ECO:0000269|PubMed:21750030}.
CC -!- SUBUNIT: Interacts with LFY. {ECO:0000269|PubMed:21750030}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:19232308, ECO:0000269|PubMed:21750030}.
CC -!- TISSUE SPECIFICITY: Expressed in the shoot apex, young flower buds,
CC developing carpels and siliques (PubMed:19232308). Expressed in floral
CC meristem, initiating floral primordia and developing flowers
CC (PubMed:21750030). {ECO:0000269|PubMed:19232308,
CC ECO:0000269|PubMed:21750030}.
CC -!- DEVELOPMENTAL STAGE: Expressed in cotyledon and hypocotyls of
CC germinating seeds. {ECO:0000269|PubMed:19232308}.
CC -!- DISRUPTION PHENOTYPE: Meristem identity phenotype; increased number of
CC cauline leaves and secondary inflorescences.
CC {ECO:0000269|PubMed:21750030}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY519601; AAS10071.1; -; mRNA.
DR EMBL; AL137898; CAB71055.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE80179.1; -; Genomic_DNA.
DR EMBL; BT033129; ACF28390.1; -; mRNA.
DR EMBL; AF062866; AAC83588.1; -; mRNA.
DR PIR; T47917; T47917.
DR PIR; T51638; T51638.
DR RefSeq; NP_191684.1; NM_115989.4.
DR AlphaFoldDB; Q9M2D9; -.
DR SMR; Q9M2D9; -.
DR STRING; 3702.AT3G61250.1; -.
DR PaxDb; Q9M2D9; -.
DR PRIDE; Q9M2D9; -.
DR EnsemblPlants; AT3G61250.1; AT3G61250.1; AT3G61250.
DR GeneID; 825297; -.
DR Gramene; AT3G61250.1; AT3G61250.1; AT3G61250.
DR KEGG; ath:AT3G61250; -.
DR Araport; AT3G61250; -.
DR TAIR; locus:2098906; AT3G61250.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_6_0_1; -.
DR InParanoid; Q9M2D9; -.
DR OMA; QTHEQYS; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q9M2D9; -.
DR PRO; PR:Q9M2D9; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M2D9; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0009909; P:regulation of flower development; IMP:TAIR.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW DNA-binding; Flowering; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..299
FT /note="Transcription factor MYB17"
FT /id="PRO_0000439926"
FT DOMAIN 9..61
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 62..116
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 37..61
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 89..112
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT CONFLICT 117
FT /note="L -> Y (in Ref. 5; AAC83588)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 299 AA; 33290 MW; CA3B002BF26316DE CRC64;
MGRTPCCDKI GLKKGPWTPE EDEVLVAHIK KNGHGSWRTL PKLAGLLRCG KSCRLRWTNY
LRPDIKRGPF TADEEKLVIQ LHAILGNRWA AIAAQLPGRT DNEIKNLWNT HLKKRLLSMG
LDPRTHEPLP SYGLAKQAPS SPTTRHMAQW ESARVEAEAR LSRESMLFSP SFYSGVVKTE
CDHFLRIWNS EIGEAFRNLA PLDESTITSQ SPCSRATSTS SALLKSSTNS WGGKEVTVAI
HGSDYSPYSN DLEDDSTDSA LQLLLDFPIS DDDMSFLEEN IDSYSQAPPI GLVSMVSKF
