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MYB1R_BETVU
ID   MYB1R_BETVU             Reviewed;         225 AA.
AC   M1ETA5;
DT   04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2013, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Transcription factor MYB1 {ECO:0000303|PubMed:25436858};
DE            Short=BvMYB1 {ECO:0000303|PubMed:25436858};
DE   AltName: Full=Anthocyanin MYB-like protein 1 {ECO:0000303|PubMed:25436858};
DE   AltName: Full=R2R3 MYB transcriptional regulator 1 {ECO:0000303|PubMed:25436858};
GN   Name=MYB1 {ECO:0000303|PubMed:25436858};
GN   Synonyms=Bv2g027795_jkkr {ECO:0000303|PubMed:25249410},
GN   Bv_jkkr {ECO:0000303|PubMed:25249410};
OS   Beta vulgaris (Sugar beet).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Caryophyllales; Chenopodiaceae; Betoideae; Beta.
OX   NCBI_TaxID=161934 {ECO:0000312|EMBL:AET43457.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DOMAIN, LACK OF INTERACTION WITH
RP   BHLH, MUTAGENESIS OF 78-LYS--LYS-85 AND LYS-97, AND INDUCTION.
RC   STRAIN=cv. W357B;
RX   PubMed=25436858; DOI=10.1038/ng.3163;
RA   Hatlestad G.J., Akhavan N.A., Sunnadeniya R.M., Elam L., Cargile S.,
RA   Hembd A., Gonzalez A., McGrath J.M., Lloyd A.M.;
RT   "The beet Y locus encodes an anthocyanin MYB-like protein that activates
RT   the betalain red pigment pathway.";
RL   Nat. Genet. 47:92-96(2015).
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. KWS2320;
RX   PubMed=25249410; DOI=10.1186/s12870-014-0249-8;
RA   Stracke R., Holtgrawe D., Schneider J., Pucker B., Rosleff Sorensen T.,
RA   Weisshaar B.;
RT   "Genome-wide identification and characterisation of R2R3-MYB genes in sugar
RT   beet (Beta vulgaris).";
RL   BMC Plant Biol. 14:249-249(2014).
CC   -!- FUNCTION: Activates DODA1 and CYP76AD1 in the betalain red pigment
CC       pathway.
CC   -!- SUBUNIT: No interactions with bHLH. {ECO:0000269|PubMed:25436858}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC   -!- INDUCTION: This dominant Y allele is highly expressed, resulting in an
CC       inner red flesh of the beet. {ECO:0000305|PubMed:25436858}.
CC   -!- DOMAIN: The C-terminus (128-225) is required for transcriptional
CC       activation. {ECO:0000269|PubMed:25436858}.
CC   -!- MISCELLANEOUS: Betalain and anthocyanin MYBs are not interchangeable
CC       and BvMYB1 cannot regulate the anthocyanin pathway in Arabidopsis.
CC       {ECO:0000269|PubMed:25436858}.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=Another shade of red - Issue
CC       169 of May 2015;
CC       URL="https://web.expasy.org/spotlight/back_issues/169/";
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DR   EMBL; JF432080; AET43457.1; -; mRNA.
DR   AlphaFoldDB; M1ETA5; -.
DR   SMR; M1ETA5; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00167; SANT; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   Pfam; PF00249; Myb_DNA-binding; 2.
DR   SMART; SM00717; SANT; 2.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS51294; HTH_MYB; 2.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Nucleus; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..225
FT                   /note="Transcription factor MYB1"
FT                   /id="PRO_0000431979"
FT   DOMAIN          11..67
FT                   /note="HTH myb-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DOMAIN          68..118
FT                   /note="HTH myb-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DNA_BIND        39..63
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DNA_BIND        91..114
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   MUTAGEN         78..85
FT                   /note="KFIIQQHK->DLIIRLHR: No effect on the lack of
FT                   interaction with bHLH. Strong interaction with bHLH; when
FT                   associated with R-97."
FT                   /evidence="ECO:0000269|PubMed:25436858"
FT   MUTAGEN         97
FT                   /note="K->R: Strong interaction with bHLH; when associated
FT                   with 78-DLIIRLHR-85."
FT                   /evidence="ECO:0000269|PubMed:25436858"
SQ   SEQUENCE   225 AA;  26294 MW;  22121D28B9EB1544 CRC64;
     MYQQNSETGS LGRVVKGSWS DEEDDLLRKC IQKYGEGNWK RVPERAGLNR CRKSCRWRWL
     NYLKPSIKRG HFNEDEVKFI IQQHKLLGNR WSLIAAKLPG RTINDVKNYC NTHLYKKHSI
     ENIPAPATNT MTHNTSSCVD RPESSATIKE PKWWENILVE LQREEKEGKS QNCSGLDFEQ
     DNLGQQDPNI NDGMDQWLNS LKEVPNLSYQ WEENLLDFDV VNLWA
 
 
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