MYB1R_BETVU
ID MYB1R_BETVU Reviewed; 225 AA.
AC M1ETA5;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2013, sequence version 1.
DT 25-MAY-2022, entry version 28.
DE RecName: Full=Transcription factor MYB1 {ECO:0000303|PubMed:25436858};
DE Short=BvMYB1 {ECO:0000303|PubMed:25436858};
DE AltName: Full=Anthocyanin MYB-like protein 1 {ECO:0000303|PubMed:25436858};
DE AltName: Full=R2R3 MYB transcriptional regulator 1 {ECO:0000303|PubMed:25436858};
GN Name=MYB1 {ECO:0000303|PubMed:25436858};
GN Synonyms=Bv2g027795_jkkr {ECO:0000303|PubMed:25249410},
GN Bv_jkkr {ECO:0000303|PubMed:25249410};
OS Beta vulgaris (Sugar beet).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC Caryophyllales; Chenopodiaceae; Betoideae; Beta.
OX NCBI_TaxID=161934 {ECO:0000312|EMBL:AET43457.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DOMAIN, LACK OF INTERACTION WITH
RP BHLH, MUTAGENESIS OF 78-LYS--LYS-85 AND LYS-97, AND INDUCTION.
RC STRAIN=cv. W357B;
RX PubMed=25436858; DOI=10.1038/ng.3163;
RA Hatlestad G.J., Akhavan N.A., Sunnadeniya R.M., Elam L., Cargile S.,
RA Hembd A., Gonzalez A., McGrath J.M., Lloyd A.M.;
RT "The beet Y locus encodes an anthocyanin MYB-like protein that activates
RT the betalain red pigment pathway.";
RL Nat. Genet. 47:92-96(2015).
RN [2]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. KWS2320;
RX PubMed=25249410; DOI=10.1186/s12870-014-0249-8;
RA Stracke R., Holtgrawe D., Schneider J., Pucker B., Rosleff Sorensen T.,
RA Weisshaar B.;
RT "Genome-wide identification and characterisation of R2R3-MYB genes in sugar
RT beet (Beta vulgaris).";
RL BMC Plant Biol. 14:249-249(2014).
CC -!- FUNCTION: Activates DODA1 and CYP76AD1 in the betalain red pigment
CC pathway.
CC -!- SUBUNIT: No interactions with bHLH. {ECO:0000269|PubMed:25436858}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- INDUCTION: This dominant Y allele is highly expressed, resulting in an
CC inner red flesh of the beet. {ECO:0000305|PubMed:25436858}.
CC -!- DOMAIN: The C-terminus (128-225) is required for transcriptional
CC activation. {ECO:0000269|PubMed:25436858}.
CC -!- MISCELLANEOUS: Betalain and anthocyanin MYBs are not interchangeable
CC and BvMYB1 cannot regulate the anthocyanin pathway in Arabidopsis.
CC {ECO:0000269|PubMed:25436858}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=Another shade of red - Issue
CC 169 of May 2015;
CC URL="https://web.expasy.org/spotlight/back_issues/169/";
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DR EMBL; JF432080; AET43457.1; -; mRNA.
DR AlphaFoldDB; M1ETA5; -.
DR SMR; M1ETA5; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..225
FT /note="Transcription factor MYB1"
FT /id="PRO_0000431979"
FT DOMAIN 11..67
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 68..118
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 39..63
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 91..114
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT MUTAGEN 78..85
FT /note="KFIIQQHK->DLIIRLHR: No effect on the lack of
FT interaction with bHLH. Strong interaction with bHLH; when
FT associated with R-97."
FT /evidence="ECO:0000269|PubMed:25436858"
FT MUTAGEN 97
FT /note="K->R: Strong interaction with bHLH; when associated
FT with 78-DLIIRLHR-85."
FT /evidence="ECO:0000269|PubMed:25436858"
SQ SEQUENCE 225 AA; 26294 MW; 22121D28B9EB1544 CRC64;
MYQQNSETGS LGRVVKGSWS DEEDDLLRKC IQKYGEGNWK RVPERAGLNR CRKSCRWRWL
NYLKPSIKRG HFNEDEVKFI IQQHKLLGNR WSLIAAKLPG RTINDVKNYC NTHLYKKHSI
ENIPAPATNT MTHNTSSCVD RPESSATIKE PKWWENILVE LQREEKEGKS QNCSGLDFEQ
DNLGQQDPNI NDGMDQWLNS LKEVPNLSYQ WEENLLDFDV VNLWA