MYB20_ARATH
ID MYB20_ARATH Reviewed; 282 AA.
AC Q9C7U7; O49759;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Transcription factor MYB20 {ECO:0000305};
DE AltName: Full=Myb-related protein 20 {ECO:0000303|PubMed:16463103};
DE Short=AtMYB20 {ECO:0000303|PubMed:11597504};
GN Name=MYB20 {ECO:0000303|PubMed:11597504};
GN OrderedLocusNames=At1g66230 {ECO:0000312|Araport:AT1G66230};
GN ORFNames=T6J19.5 {ECO:0000312|EMBL:AAG51765.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF Clones.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-278.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [8]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=23660402; DOI=10.1016/j.febslet.2013.04.028;
RA Cui M.H., Yoo K.S., Hyoung S., Nguyen H.T., Kim Y.Y., Kim H.J., Ok S.H.,
RA Yoo S.D., Shin J.S.;
RT "An Arabidopsis R2R3-MYB transcription factor, AtMYB20, negatively
RT regulates type 2C serine/threonine protein phosphatases to enhance salt
RT tolerance.";
RL FEBS Lett. 587:1773-1778(2013).
CC -!- FUNCTION: Transcription factor that acts as positive regulator of
CC abscisic acid (ABA) signaling in response to salt stress. Acts as
CC negative regulator ABI1, ABI2 and PP2CA, which are protein phosphatases
CC 2C acting as negative regulator of ABA signaling. Binds to the DNA
CC specific sequence and core element 5'-ACGT-3' found in the promoters of
CC ABI1 and PP2CA to negatively regulate their expression during ABA-
CC dependent salt stress response. {ECO:0000269|PubMed:23660402}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:23660402}.
CC -!- TISSUE SPECIFICITY: Expressed in chalaza of mature seeds, cotyledons,
CC rosette leaves, cauline leaves, veins of stems, mature siliques, sepals
CC and styles. Expressed at low levels in roots.
CC {ECO:0000269|PubMed:23660402}.
CC -!- INDUCTION: Induced by salt stress, drought stress and abscisic acid
CC (ABA). Down-regulated by salicylic acid (SA) methyl jasmonate (JA).
CC {ECO:0000269|PubMed:23660402}.
CC -!- MISCELLANEOUS: Plants overexpressing MYB20 display increased tolerance
CC to salt stress. {ECO:0000269|PubMed:23660402}.
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DR EMBL; AY519565; AAS10035.1; -; mRNA.
DR EMBL; AC066691; AAG51765.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34479.1; -; Genomic_DNA.
DR EMBL; BT028904; ABI49451.1; -; mRNA.
DR EMBL; AF062869; AAC83591.1; -; mRNA.
DR PIR; C96687; C96687.
DR PIR; T51641; T51641.
DR PIR; T52282; T52282.
DR RefSeq; NP_176797.1; NM_105294.3.
DR AlphaFoldDB; Q9C7U7; -.
DR SMR; Q9C7U7; -.
DR STRING; 3702.AT1G66230.1; -.
DR PaxDb; Q9C7U7; -.
DR PRIDE; Q9C7U7; -.
DR EnsemblPlants; AT1G66230.1; AT1G66230.1; AT1G66230.
DR GeneID; 842938; -.
DR Gramene; AT1G66230.1; AT1G66230.1; AT1G66230.
DR KEGG; ath:AT1G66230; -.
DR Araport; AT1G66230; -.
DR TAIR; locus:2205283; AT1G66230.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_20_0_1; -.
DR InParanoid; Q9C7U7; -.
DR OMA; ISWINCF; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q9C7U7; -.
DR PRO; PR:Q9C7U7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C7U7; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0009094; P:L-phenylalanine biosynthetic process; IGI:TAIR.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:1901002; P:positive regulation of response to salt stress; IMP:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:TAIR.
DR GO; GO:1901141; P:regulation of lignin biosynthetic process; IGI:TAIR.
DR GO; GO:2000762; P:regulation of phenylpropanoid metabolic process; IGI:TAIR.
DR GO; GO:2000652; P:regulation of secondary cell wall biogenesis; IMP:TAIR.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Stress response;
KW Transcription; Transcription regulation.
FT CHAIN 1..282
FT /note="Transcription factor MYB20"
FT /id="PRO_0000441920"
FT DOMAIN 9..61
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 62..116
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 37..61
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 89..112
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT CONFLICT 114
FT /note="K -> T (in Ref. 6; AAC83591)"
FT /evidence="ECO:0000305"
FT CONFLICT 123
FT /note="P -> L (in Ref. 6; AAC83591)"
FT /evidence="ECO:0000305"
FT CONFLICT 238
FT /note="N -> S (in Ref. 6; AAC83591)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 282 AA; 32336 MW; 073D9EDA513A3D03 CRC64;
MGRQPCCDKV GLKKGPWTAE EDRKLINFIL TNGQCCWRAV PKLSGLLRCG KSCRLRWTNY
LRPDLKRGLL SDYEEKMVID LHSQLGNRWS KIASHLPGRT DNEIKNHWNT HIKKKLRKMG
IDPLTHKPLS IVEKEDEEPL KKLQNNTVPF QETMERPLEN NIKNISRLEE SLGDDQFMEI
NLEYGVEDVP LIETESLDLI CSNSTMSSST STSSHSSNDS SFLKDLQFPE FEWSDYGNSN
NDNNNGVDNI IENNMMSLWE ISDFSSLDLL LNDESSSTFG LF
