MYB23_ARATH
ID MYB23_ARATH Reviewed; 219 AA.
AC Q96276; O49760;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Transcription factor MYB23;
DE AltName: Full=Myb-related protein 23;
DE Short=AtMYB23;
GN Name=MYB23; OrderedLocusNames=At5g40330; ORFNames=MPO12.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND TISSUE
RP SPECIFICITY.
RC STRAIN=cv. Landsberg erecta; TISSUE=Silique;
RX PubMed=11437443; DOI=10.1006/dbio.2001.0287;
RA Kirik V., Schnittger A., Radchuk V., Adler K., Huelskamp M., Baeumlein H.;
RT "Ectopic expression of the Arabidopsis AtMYB23 gene induces differentiation
RT of trichome cells.";
RL Dev. Biol. 235:366-377(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L.-J., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9405937; DOI=10.1093/dnares/4.4.291;
RA Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence
RT features of the regions of 1,044,062 bp covered by thirteen physically
RT assigned P1 clones.";
RL DNA Res. 4:291-300(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 55-99.
RC STRAIN=cv. Landsberg erecta;
RA Romero I., Fuertes A., Benito M.J., Malpica J., Leyva A., Paz-Ares J.;
RT "One hundred R2R3-MYB genes in the genome of Arabidopsis thaliana.";
RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [8]
RP FUNCTION, AND INTERACTION WITH BHLH2 AND BHLH12.
RX PubMed=15361138; DOI=10.1111/j.1365-313x.2004.02183.x;
RA Zimmermann I.M., Heim M.A., Weisshaar B., Uhrig J.F.;
RT "Comprehensive identification of Arabidopsis thaliana MYB transcription
RT factors interacting with R/B-like BHLH proteins.";
RL Plant J. 40:22-34(2004).
RN [9]
RP FUNCTION.
RX PubMed=15668208; DOI=10.1093/pcp/pci005;
RA Matsui K., Hiratsu K., Koyama T., Tanaka H., Ohme-Takagi M.;
RT "A chimeric AtMYB23 repressor induces hairy roots, elongation of leaves and
RT stems, and inhibition of the deposition of mucilage on seed coats in
RT Arabidopsis.";
RL Plant Cell Physiol. 46:147-155(2005).
RN [10]
RP FUNCTION, INTERACTION WITH GL3, AND DEVELOPMENTAL STAGE.
RX PubMed=15728674; DOI=10.1242/dev.01708;
RA Kirik V., Lee M.M., Wester K., Herrmann U., Zheng Z., Oppenheimer D.,
RA Schiefelbein J., Hulskamp M.;
RT "Functional diversification of MYB23 and GL1 genes in trichome
RT morphogenesis and initiation.";
RL Development 132:1477-1485(2005).
RN [11]
RP GENE FAMILY.
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
CC -!- FUNCTION: Transcription activator, when associated with
CC BHLH2/EGL3/MYC146 or BHLH12/MYC1. Regulates the epidermal cell fate
CC specification. Mediates the formation of columellae and accumulation of
CC mucilages on seed coats. Controls the elongation of epidermal cells
CC positively in roots but negatively in stems, leading to the promotion
CC of primary roots elongation and repression of leaves and stems
CC elongation, respectively. Ovoids ectopic root-hair formation, probably
CC by inducing GL2 in roots. Controls trichome initiation and branching.
CC {ECO:0000269|PubMed:11437443, ECO:0000269|PubMed:15361138,
CC ECO:0000269|PubMed:15668208, ECO:0000269|PubMed:15728674}.
CC -!- SUBUNIT: Interacts with BHLH2/EGL3/MYC146, BHLH12/MYC1 and GL3.
CC {ECO:0000269|PubMed:15361138, ECO:0000269|PubMed:15728674}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, seed coats, leaves, stems and
CC flowers. Detected specifically in trichomes, and in the cell division
CC and differentiation zone of the root. {ECO:0000269|PubMed:11437443}.
CC -!- DEVELOPMENTAL STAGE: First expressed in leaf primordia. Later confined
CC to developing trichome cells where it persists at high levels
CC throughout all stages of trichome development.
CC {ECO:0000269|PubMed:11437443, ECO:0000269|PubMed:15728674}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z68158; CAA92281.1; -; mRNA.
DR EMBL; AY519631; AAS10101.1; -; mRNA.
DR EMBL; AB006702; BAB11588.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94534.1; -; Genomic_DNA.
DR EMBL; BT025285; ABF19038.1; -; mRNA.
DR EMBL; Z95747; CAB09179.1; -; mRNA.
DR PIR; T52283; T52283.
DR RefSeq; NP_198849.1; NM_123397.3.
DR AlphaFoldDB; Q96276; -.
DR SMR; Q96276; -.
DR BioGRID; 19282; 11.
DR IntAct; Q96276; 6.
DR STRING; 3702.AT5G40330.1; -.
DR PaxDb; Q96276; -.
DR PRIDE; Q96276; -.
DR EnsemblPlants; AT5G40330.1; AT5G40330.1; AT5G40330.
DR GeneID; 834031; -.
DR Gramene; AT5G40330.1; AT5G40330.1; AT5G40330.
DR KEGG; ath:AT5G40330; -.
DR Araport; AT5G40330; -.
DR TAIR; locus:2170553; AT5G40330.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_25_8_1; -.
DR InParanoid; Q96276; -.
DR OMA; TFWVLED; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q96276; -.
DR PRO; PR:Q96276; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q96276; baseline and differential.
DR Genevisible; Q96276; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0010053; P:root epidermal cell differentiation; IMP:TAIR.
DR GO; GO:0010091; P:trichome branching; IMP:TAIR.
DR GO; GO:0010026; P:trichome differentiation; IMP:TAIR.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation.
FT CHAIN 1..219
FT /note="Transcription factor MYB23"
FT /id="PRO_0000285270"
FT DOMAIN 9..61
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 62..116
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 37..61
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 89..112
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT CONFLICT 83
FT /note="K -> R (in Ref. 6; CAB09179)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 219 AA; 24943 MW; 774DE100200B50FF CRC64;
MRMTRDGKEH EYKKGLWTVE EDKILMDYVR THGQGHWNRI AKKTGLKRCG KSCRLRWMNY
LSPNVNRGNF TDQEEDLIIR LHKLLGNRWS LIAKRVPGRT DNQVKNYWNT HLSKKLGLGD
HSTAVKAACG VESPPSMALI TTTSSSHQEI SGGKNSTLRF DTLVDESKLK PKSKLVHATP
TDVEVAATVP NLFDTFWVLE DDFELSSLTM MDFTNGYCL
