MYB25_ARATH
ID MYB25_ARATH Reviewed; 367 AA.
AC O04192;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Transcription factor MYB25 {ECO:0000303|PubMed:11597504};
DE AltName: Full=Myb-related protein 25 {ECO:0000303|PubMed:11597504};
DE Short=AtMYB25 {ECO:0000303|PubMed:11597504};
GN Name=MYB25 {ECO:0000303|PubMed:11597504};
GN OrderedLocusNames=At2g39880 {ECO:0000312|Araport:AT2G39880};
GN ORFNames=T28M21.4 {ECO:0000312|EMBL:AAB95273.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Fujita M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [6]
RP INDUCTION.
RX PubMed=15258262; DOI=10.1105/tpc.104.022830;
RA Sunkar R., Zhu J.-K.;
RT "Novel and stress-regulated microRNAs and other small RNAs from
RT Arabidopsis.";
RL Plant Cell 16:2001-2019(2004).
RN [7]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22101548; DOI=10.1007/s00497-011-0178-8;
RA Renak D., Dupl'akova N., Honys D.;
RT "Wide-scale screening of T-DNA lines for transcription factor genes
RT affecting male gametophyte development in Arabidopsis.";
RL Sex. Plant Reprod. 25:39-60(2012).
CC -!- FUNCTION: Required for male gametophyte (pollen) development.
CC {ECO:0000269|PubMed:22101548}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- INDUCTION: May be the target of the microRNA (miRNA) MIR393a.
CC {ECO:0000269|PubMed:15258262}.
CC -!- DISRUPTION PHENOTYPE: Abnormal male gametophyte (pollen) development
CC including deformed cell wall, two-celled phenotype (one regular
CC vegetative nucleus and one sperm cell-like nucleus, both in center) and
CC semtimes leading to abortion. {ECO:0000269|PubMed:22101548}.
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DR EMBL; AF175988; AAD53093.1; -; mRNA.
DR EMBL; AB493582; BAH30420.1; -; mRNA.
DR EMBL; AC003000; AAM14852.1; -; Genomic_DNA.
DR EMBL; AF002109; AAB95273.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09744.1; -; Genomic_DNA.
DR PIR; T01017; T01017.
DR RefSeq; NP_181517.1; NM_129546.2.
DR AlphaFoldDB; O04192; -.
DR SMR; O04192; -.
DR STRING; 3702.AT2G39880.1; -.
DR PaxDb; O04192; -.
DR PRIDE; O04192; -.
DR EnsemblPlants; AT2G39880.1; AT2G39880.1; AT2G39880.
DR GeneID; 818575; -.
DR Gramene; AT2G39880.1; AT2G39880.1; AT2G39880.
DR KEGG; ath:AT2G39880; -.
DR Araport; AT2G39880; -.
DR TAIR; locus:2061242; AT2G39880.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_047891_3_0_1; -.
DR InParanoid; O04192; -.
DR OMA; NIDCEPM; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; O04192; -.
DR PRO; PR:O04192; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O04192; baseline and differential.
DR GO; GO:0016607; C:nuclear speck; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009555; P:pollen development; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..367
FT /note="Transcription factor MYB25"
FT /id="PRO_0000438811"
FT DOMAIN 45..100
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 101..151
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 73..96
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 124..147
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 181..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 367 AA; 40912 MW; 9365BA5780EF7C7B CRC64;
MNGEISRPPE LISSRNPCKS FENAIHKAVE AELAELAKSD ANGGGKSKVK GPWLPEQDEA
LTRLVKMCGP RNWNLISRGI PGRSGKSCRL RWCNQLDPIL KRKPFSDEEE HMIMSAQAVL
GNKWSVIAKL LPGRTDNAIK NHWNSNLRRK PAEQWKIPLL MSNTEIVYQL YPSMVRRISN
ASPKEHLPQE EETGVLSDDK MDDEAKEPPR EQNSKTGVYR PVARMGAFSV CKPGYMAPCE
GPLVQASRPD SLAGKFLQSL CYDPIIPSKC GHGCCNHQDS TTLSSSSVLG SEFVDYEEHS
SAELDKELIS ISNDLNNTAW IRSGKEAEQS LKADDQFRRE YAHSKFSGMV NNGVSSQMVR
QDLRALS
