MYB33_ARATH
ID MYB33_ARATH Reviewed; 520 AA.
AC Q8W1W6; A0A178UNH0; B2CUN6; Q9LHS6; Q9ZTE7;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Transcription factor MYB33 {ECO:0000303|PubMed:11597504};
DE AltName: Full=Myb-related protein 33 {ECO:0000303|PubMed:11597504};
DE Short=AtMYB33 {ECO:0000303|PubMed:11597504};
GN Name=MYB33 {ECO:0000303|PubMed:11597504};
GN OrderedLocusNames=At5g06100 {ECO:0000312|Araport:AT5G06100};
GN ORFNames=K16F4.6 {ECO:0000312|EMBL:BAA98199.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY,
RP DEVELOPMENTAL STAGE, AND INDUCTION BY GIBBERELLINS AND FLOWERING.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX PubMed=11743113; DOI=10.1104/pp.010442;
RA Gocal G.F.W., Sheldon C.C., Gubler F., Moritz T., Bagnall D.J.,
RA MacMillan C.P., Li S.F., Parish R.W., Dennis E.S., Weigel D., King R.W.;
RT "GAMYB-like genes, flowering, and gibberellin signaling in Arabidopsis.";
RL Plant Physiol. 127:1682-1693(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: A genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 75-452 (ISOFORM 2), TISSUE SPECIFICITY,
RP INDUCTION BY ETHYLENE AND CYTOKININS, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 250-393 (ISOFORM 1/2), AND REGULATION
RP BY MIR159.
RC STRAIN=cv. Ag-0, cv. An-1, cv. Bay-0, cv. C24, cv. Ct-1, cv. Cvi-0,
RC cv. Edi-0, cv. Ei-2, cv. Ga-0, cv. Gy-0, cv. Kas-2, cv. Ll-0, cv. Mrk-0,
RC cv. Ms-0, cv. Mt-0, cv. Nd-1, cv. Nok-3, cv. Oy-0, cv. Sorbo, cv. Wa-1,
RC cv. Wassilewskija, cv. Wei-0, and cv. Wt-5;
RX PubMed=18305205; DOI=10.1104/pp.108.116582;
RA Ehrenreich I.M., Purugganan M.D.;
RT "Sequence variation of microRNAs and their binding sites in Arabidopsis.";
RL Plant Physiol. 146:1974-1982(2008).
RN [9]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [10]
RP FUNCTION, AND REPRESSION BY MICRORNA159.
RX PubMed=15226253; DOI=10.1242/dev.01206;
RA Achard P., Herr A., Baulcombe D.C., Harberd N.P.;
RT "Modulation of floral development by a gibberellin-regulated microRNA.";
RL Development 131:3357-3365(2004).
RN [11]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND REGULATION BY MIR159.
RC STRAIN=cv. Columbia;
RX PubMed=15722475; DOI=10.1105/tpc.104.027920;
RA Millar A.A., Gubler F.;
RT "The Arabidopsis GAMYB-like genes, MYB33 and MYB65, are microRNA-regulated
RT genes that redundantly facilitate anther development.";
RL Plant Cell 17:705-721(2005).
RN [12]
RP FUNCTION, DISRUPTION PHENOTYPE, AND REPRESSION BY MICRORNA159.
RC STRAIN=cv. Columbia;
RX PubMed=17217461; DOI=10.1111/j.1365-313x.2006.02980.x;
RA Reyes J.L., Chua N.-H.;
RT "ABA induction of miR159 controls transcript levels of two MYB factors
RT during Arabidopsis seed germination.";
RL Plant J. 49:592-606(2007).
RN [13]
RP REPRESSION BY MICRORNA159.
RX PubMed=17916625; DOI=10.1073/pnas.0707653104;
RA Allen R.S., Li J., Stahle M.I., Dubroue A., Gubler F., Millar A.A.;
RT "Genetic analysis reveals functional redundancy and the major target genes
RT of the Arabidopsis miR159 family.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:16371-16376(2007).
RN [14]
RP FUNCTION, DISRUPTION PHENOTYPE, AND REPRESSION BY MICRORNA159.
RC STRAIN=cv. Columbia;
RX PubMed=20699403; DOI=10.1104/pp.110.160630;
RA Alonso-Peral M.M., Li J., Li Y., Allen R.S., Schnippenkoetter W., Ohms S.,
RA White R.G., Millar A.A.;
RT "The microRNA159-regulated GAMYB-like genes inhibit growth and promote
RT programmed cell death in Arabidopsis.";
RL Plant Physiol. 154:757-771(2010).
RN [15]
RP TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=24278028; DOI=10.1371/journal.pgen.1003933;
RA Liang Y., Tan Z.-M., Zhu L., Niu Q.-K., Zhou J.-J., Li M., Chen L.-Q.,
RA Zhang X.-Q., Ye D.;
RT "MYB97, MYB101 and MYB120 function as male factors that control pollen
RT tube-synergid interaction in Arabidopsis thaliana fertilization.";
RL PLoS Genet. 9:E1003933-E1003933(2013).
CC -!- FUNCTION: Transcriptional activator of alpha-amylase expression that
CC binds to 5'-CAACTGTC-3' motif in target gene promoter
CC (PubMed:11743113). Positive regulator of abscisic acid (ABA) responses
CC leading to growth arrest during seed germination (PubMed:17217461). In
CC vegetative tissues, inhibits growth by reducing cell proliferation.
CC Promotes the expression of aleurone-related genes (e.g. CP1, CP, GASA1,
CC BXL1 and BXL2) in seeds. Together with MYB65 and MYB101, promotes the
CC programmed cell death (PCD) the vacuolation of protein storage vacuoles
CC (PSVs) in the aleurone layers during seed germination
CC (PubMed:20699403). Binds to a GARE site (GA-response element) in the
CC LEAFY promoter, essential for its gibberellic acid (GA)-mediated
CC induction (PubMed:15226253). Together with MYB65, facilitates anther
CC and tapetum development (PubMed:15722475).
CC {ECO:0000269|PubMed:11743113, ECO:0000269|PubMed:15226253,
CC ECO:0000269|PubMed:15722475, ECO:0000269|PubMed:17217461,
CC ECO:0000269|PubMed:20699403}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8W1W6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8W1W6-2; Sequence=VSP_058813, VSP_058814;
CC -!- TISSUE SPECIFICITY: Mostly expressed in stems, shoot apices, flowers
CC and floral shoot tips, and, to a lower extent, in roots (e.g. root
CC tips), seedlings, leaves and siliques. {ECO:0000269|PubMed:11743113,
CC ECO:0000269|PubMed:15722475, ECO:0000269|PubMed:24278028,
CC ECO:0000269|PubMed:9839469}.
CC -!- DEVELOPMENTAL STAGE: In germinating seeds, present in the root tip and
CC in a linear array of up to 20 to 30 cells above the root tip. Weak
CC expression in the vegetative shoot apex. High levels in primordial
CC leaves. Strongly expressed in the inflorescence apex, and, to some
CC extent, in the inflorescence stem, the vascular tissue, and the
CC vascular tissue in leaf primordia. In the gynoecium, confined to
CC ovules. In developing anthers detected in developing locules of
CC immature anthers and later, at low levels, in pollen grains
CC (PubMed:11743113). In flowers, expressed in sepals, style, receptacle,
CC anther filaments, especially in young anthers, and connective but not
CC in anthers themselves (PubMed:15722475). {ECO:0000269|PubMed:11743113,
CC ECO:0000269|PubMed:15722475}.
CC -!- INDUCTION: Accumulates at the shoot apex upon the transition from
CC short- to long-day photoperiods leading to flowering and after
CC gibberellins (GAs) treatment (PubMed:11743113). Repressed by
CC microRNA159 (miR159a and miR159b) in vegetative tissues
CC (PubMed:15226253, PubMed:20699403, PubMed:17916625). Specific
CC expression in floral organs and in the shoot apices is regulated via
CC miR159-mediated degradation (PubMed:15722475). Repressed in germinating
CC seeds by miR159-mediated cleavage in an abscisic acid (ABA) and ABI3-
CC dependent manner, probably to desensitize hormone signaling during
CC seedling stress responses (PubMed:17217461, PubMed:18305205). Slightly
CC induced by ethylene and cytokinins (PubMed:9839469).
CC {ECO:0000269|PubMed:11743113, ECO:0000269|PubMed:15226253,
CC ECO:0000269|PubMed:15722475, ECO:0000269|PubMed:17217461,
CC ECO:0000269|PubMed:17916625, ECO:0000269|PubMed:18305205,
CC ECO:0000269|PubMed:20699403, ECO:0000269|PubMed:9839469}.
CC -!- DISRUPTION PHENOTYPE: Hyposensitivity to abscisic acid (ABA)
CC (PubMed:17217461). Reduced expression levels of aleurone-related genes
CC (e.g. CP1, CP, GASA1, BXL1 and BXL2) in seeds. The triple mutant myb33
CC myb65 myb101 has a male sterility and exhibits slower protein storage
CC vacuoles (PSVs) vacuolation rate in aleurone layers upon seed
CC germination (PubMed:20699403). The myb33 myb65 double mutant is
CC defective in anther development, with a tapetum undergoing hypertrophy
CC at the pollen mother cell stage, resulting in premeiotic abortion of
CC pollen development and male sterility. This sterility is conditional,
CC fertility being increased both under higher light or lower temperature
CC conditions (PubMed:15722475). {ECO:0000269|PubMed:15722475,
CC ECO:0000269|PubMed:17217461, ECO:0000269|PubMed:20699403}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC83597.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF411969; AAL58844.1; -; mRNA.
DR EMBL; AY519616; AAS10086.1; -; mRNA.
DR EMBL; AP002030; BAA98199.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90964.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90965.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90966.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM69304.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM69305.1; -; Genomic_DNA.
DR EMBL; AK118937; BAC43518.1; -; mRNA.
DR EMBL; BT006049; AAP04034.1; -; mRNA.
DR EMBL; AF062875; AAC83597.1; ALT_FRAME; mRNA.
DR EMBL; EU550609; ACB31371.1; -; Genomic_DNA.
DR EMBL; EU550587; ACB31349.1; -; Genomic_DNA.
DR EMBL; EU550588; ACB31350.1; -; Genomic_DNA.
DR EMBL; EU550589; ACB31351.1; -; Genomic_DNA.
DR EMBL; EU550591; ACB31353.1; -; Genomic_DNA.
DR EMBL; EU550590; ACB31352.1; -; Genomic_DNA.
DR EMBL; EU550592; ACB31354.1; -; Genomic_DNA.
DR EMBL; EU550593; ACB31355.1; -; Genomic_DNA.
DR EMBL; EU550594; ACB31356.1; -; Genomic_DNA.
DR EMBL; EU550595; ACB31357.1; -; Genomic_DNA.
DR EMBL; EU550597; ACB31359.1; -; Genomic_DNA.
DR EMBL; EU550596; ACB31358.1; -; Genomic_DNA.
DR EMBL; EU550598; ACB31360.1; -; Genomic_DNA.
DR EMBL; EU550599; ACB31361.1; -; Genomic_DNA.
DR EMBL; EU550600; ACB31362.1; -; Genomic_DNA.
DR EMBL; EU550601; ACB31363.1; -; Genomic_DNA.
DR EMBL; EU550602; ACB31364.1; -; Genomic_DNA.
DR EMBL; EU550603; ACB31365.1; -; Genomic_DNA.
DR EMBL; EU550604; ACB31366.1; -; Genomic_DNA.
DR EMBL; EU550605; ACB31367.1; -; Genomic_DNA.
DR EMBL; EU550606; ACB31368.1; -; Genomic_DNA.
DR EMBL; EU550607; ACB31369.1; -; Genomic_DNA.
DR EMBL; EU550608; ACB31370.1; -; Genomic_DNA.
DR PIR; T51647; T51647.
DR RefSeq; NP_001078537.1; NM_001085068.2. [Q8W1W6-1]
DR RefSeq; NP_001330996.1; NM_001342849.1. [Q8W1W6-1]
DR RefSeq; NP_001330997.1; NM_001342848.1. [Q8W1W6-1]
DR RefSeq; NP_196228.1; NM_120692.3. [Q8W1W6-2]
DR RefSeq; NP_850779.1; NM_180448.2. [Q8W1W6-1]
DR AlphaFoldDB; Q8W1W6; -.
DR SMR; Q8W1W6; -.
DR IntAct; Q8W1W6; 2.
DR STRING; 3702.AT5G06100.2; -.
DR iPTMnet; Q8W1W6; -.
DR PaxDb; Q8W1W6; -.
DR PRIDE; Q8W1W6; -.
DR EnsemblPlants; AT5G06100.1; AT5G06100.1; AT5G06100. [Q8W1W6-2]
DR EnsemblPlants; AT5G06100.2; AT5G06100.2; AT5G06100. [Q8W1W6-1]
DR EnsemblPlants; AT5G06100.3; AT5G06100.3; AT5G06100. [Q8W1W6-1]
DR EnsemblPlants; AT5G06100.4; AT5G06100.4; AT5G06100. [Q8W1W6-1]
DR EnsemblPlants; AT5G06100.5; AT5G06100.5; AT5G06100. [Q8W1W6-1]
DR GeneID; 830497; -.
DR Gramene; AT5G06100.1; AT5G06100.1; AT5G06100. [Q8W1W6-2]
DR Gramene; AT5G06100.2; AT5G06100.2; AT5G06100. [Q8W1W6-1]
DR Gramene; AT5G06100.3; AT5G06100.3; AT5G06100. [Q8W1W6-1]
DR Gramene; AT5G06100.4; AT5G06100.4; AT5G06100. [Q8W1W6-1]
DR Gramene; AT5G06100.5; AT5G06100.5; AT5G06100. [Q8W1W6-1]
DR KEGG; ath:AT5G06100; -.
DR Araport; AT5G06100; -.
DR TAIR; locus:2152830; AT5G06100.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_023548_1_1_1; -.
DR InParanoid; Q8W1W6; -.
DR OMA; DKDETIM; -.
DR PhylomeDB; Q8W1W6; -.
DR PRO; PR:Q8W1W6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8W1W6; baseline and differential.
DR GO; GO:0005634; C:nucleus; TAS:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0048653; P:anther development; IMP:UniProtKB.
DR GO; GO:0048655; P:anther wall tapetum morphogenesis; IMP:UniProtKB.
DR GO; GO:0009740; P:gibberellic acid mediated signaling pathway; TAS:TAIR.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:UniProtKB.
DR GO; GO:0045926; P:negative regulation of growth; IMP:TAIR.
DR GO; GO:0048235; P:pollen sperm cell differentiation; IGI:TAIR.
DR GO; GO:0009789; P:positive regulation of abscisic acid-activated signaling pathway; IMP:TAIR.
DR GO; GO:0043068; P:positive regulation of programmed cell death; IMP:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:TAIR.
DR GO; GO:1990019; P:protein storage vacuole organization; IMP:UniProtKB.
DR GO; GO:0009735; P:response to cytokinin; IEP:UniProtKB.
DR GO; GO:0009723; P:response to ethylene; IEP:UniProtKB.
DR GO; GO:0009739; P:response to gibberellin; IEP:UniProtKB.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR016310; GAMYB-like.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR PIRSF; PIRSF001693; Transcription_factor_GAMYB; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; Developmental protein; Differentiation;
KW DNA-binding; Flowering; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..520
FT /note="Transcription factor MYB33"
FT /id="PRO_0000439242"
FT DOMAIN 29..81
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 82..136
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 57..81
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 109..132
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 438..451
FT /note="RQREKKRKPLLDIT -> SELLFTLPSLEIVC (in isoform 2)"
FT /id="VSP_058813"
FT VAR_SEQ 452..520
FT /note="Missing (in isoform 2)"
FT /id="VSP_058814"
FT CONFLICT 171
FT /note="Q -> P (in Ref. 7; AAC83597)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 520 AA; 58395 MW; EDF805F309D7096D CRC64;
MSYTSTDSDH NESPAADDNG SDCRSRWDGH ALKKGPWSSA EDDILIDYVN KHGEGNWNAV
QKHTSLFRCG KSCRLRWANH LRPNLKKGAF SQEEEQLIVE LHAKMGNRWA RMAAHLPGRT
DNEIKNYWNT RIKRRQRAGL PLYPPEMHVE ALEWSQEYAK SRVMGEDRRH QDFLQLGSCE
SNVFFDTLNF TDMVPGTFDL ADMTAYKNMG NCASSPRYEN FMTPTIPSSK RLWESELLYP
GCSSTIKQEF SSPEQFRNTS PQTISKTCSF SVPCDVEHPL YGNRHSPVMI PDSHTPTDGI
VPYSKPLYGA VKLELPSFQY SETTFDQWKK SSSPPHSDLL DPFDTYIQSP PPPTGGEESD
LYSNFDTGLL DMLLLEAKIR NNSTKNNLYR SCASTIPSAD LGQVTVSQTK SEEFDNSLKS
FLVHSEMSTQ NADETPPRQR EKKRKPLLDI TRPDVLLASS WLDHGLGIVK ETGSMSDALA
VLLGDDIGND YMNMSVGASS GVGSCSWSNM PPVCQMTELP
