MYB34_ARATH
ID MYB34_ARATH Reviewed; 295 AA.
AC O64399; Q9SBG1;
DT 11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Transcription factor MYB34;
DE AltName: Full=Myb-related protein 34;
DE Short=AtMYB34;
DE AltName: Full=Protein ALTERED TRYPTOPHAN REGULATION 1;
DE Short=ATR1;
GN Name=MYB34; Synonyms=ATR1; OrderedLocusNames=At5g60890; ORFNames=MSL3.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=cv. Columbia;
RX PubMed=9576939; DOI=10.1073/pnas.95.10.5655;
RA Bender J., Fink G.R.;
RT "A Myb homologue, ATR1, activates tryptophan gene expression in
RT Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:5655-5660(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9501997; DOI=10.1093/dnares/4.6.401;
RA Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence
RT features of the regions of 1,191,918 bp covered by seventeen physically
RT assigned P1 clones.";
RL DNA Res. 4:401-414(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 76-295.
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [8]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=15579661; DOI=10.1104/pp.104.054395;
RA Celenza J.L., Quiel J.A., Smolen G.A., Merrikh H., Silvestro A.R.,
RA Normanly J., Bender J.;
RT "The Arabidopsis ATR1 Myb transcription factor controls indolic
RT glucosinolate homeostasis.";
RL Plant Physiol. 137:253-262(2005).
RN [9]
RP TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=23115560; DOI=10.3389/fpls.2012.00242;
RA Frerigmann H., Boettcher C., Baatout D., Gigolashvili T.;
RT "Glucosinolates are produced in trichomes of Arabidopsis thaliana.";
RL Front. Plant Sci. 3:242-242(2012).
RN [10]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=23580754; DOI=10.1093/jxb/ert094;
RA Guo R., Qian H., Shen W., Liu L., Zhang M., Cai C., Zhao Y., Qiao J.,
RA Wang Q.;
RT "BZR1 and BES1 participate in regulation of glucosinolate biosynthesis by
RT brassinosteroids in Arabidopsis.";
RL J. Exp. Bot. 64:2401-2412(2013).
RN [11]
RP FUNCTION, INTERACTION WITH MYC2; MYC3 AND MYC4, AND INDUCTION BY HERBIVORY.
RX PubMed=23943862; DOI=10.1105/tpc.113.115139;
RA Schweizer F., Fernandez-Calvo P., Zander M., Diez-Diaz M., Fonseca S.,
RA Glauser G., Lewsey M.G., Ecker J.R., Solano R., Reymond P.;
RT "Arabidopsis basic helix-loop-helix transcription factors MYC2, MYC3, and
RT MYC4 regulate glucosinolate biosynthesis, insect performance, and feeding
RT behavior.";
RL Plant Cell 25:3117-3132(2013).
CC -!- FUNCTION: Transcription factor involved in tryptophan gene activation
CC and in indole-3-acetic acid (IAA) and indolic glucosinolates (IG)
CC biosynthesis. Acts as a direct transcriptional activator of both Trp
CC synthesis genes and Trp secondary metabolism genes.
CC {ECO:0000269|PubMed:15579661, ECO:0000269|PubMed:23580754,
CC ECO:0000269|PubMed:23943862, ECO:0000269|PubMed:9576939}.
CC -!- SUBUNIT: Can form complexes with MYC2, MYC3 or MYC4.
CC -!- INTERACTION:
CC O64399; A0A1P8BA81: MTI20.21; NbExp=3; IntAct=EBI-25517538, EBI-25517523;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in trichomes.
CC {ECO:0000269|PubMed:23115560}.
CC -!- INDUCTION: Up-regulated by herbivory. {ECO:0000269|PubMed:23943862}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype. Reduced indolic
CC glucosinolate levels in adult leaves and loss of responses to
CC brassinosteroids. {ECO:0000269|PubMed:15579661,
CC ECO:0000269|PubMed:23580754}.
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DR EMBL; U66462; AAC16897.1; -; Genomic_DNA.
DR EMBL; AY519642; AAS10112.1; -; mRNA.
DR EMBL; AB008269; BAB10639.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97393.1; -; Genomic_DNA.
DR EMBL; BT030326; ABO09889.1; -; mRNA.
DR EMBL; AF062876; AAC83598.1; -; mRNA.
DR PIR; T51648; T51648.
DR RefSeq; NP_200897.1; NM_125482.3.
DR AlphaFoldDB; O64399; -.
DR SMR; O64399; -.
DR BioGRID; 21454; 5.
DR IntAct; O64399; 1.
DR STRING; 3702.AT5G60890.1; -.
DR PaxDb; O64399; -.
DR PRIDE; O64399; -.
DR EnsemblPlants; AT5G60890.1; AT5G60890.1; AT5G60890.
DR GeneID; 836210; -.
DR Gramene; AT5G60890.1; AT5G60890.1; AT5G60890.
DR KEGG; ath:AT5G60890; -.
DR Araport; AT5G60890; -.
DR TAIR; locus:2173562; AT5G60890.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_6_1_1; -.
DR OMA; DNCSFTD; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; O64399; -.
DR PRO; PR:O64399; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; O64399; baseline and differential.
DR Genevisible; O64399; AT.
DR GO; GO:0005634; C:nucleus; HDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0010438; P:cellular response to sulfur starvation; TAS:TAIR.
DR GO; GO:0002213; P:defense response to insect; IMP:TAIR.
DR GO; GO:0009759; P:indole glucosinolate biosynthetic process; IMP:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:TAIR.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IMP:TAIR.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..295
FT /note="Transcription factor MYB34"
FT /id="PRO_0000424711"
FT DOMAIN 9..61
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 62..116
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 37..61
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 89..112
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
SQ SEQUENCE 295 AA; 32743 MW; AF662C5309EC9D4F CRC64;
MVRTPCCKEE GIKKGAWTPE EDQKLIAYLH LHGEGGWRTL PEKAGLKRCG KSCRLRWANY
LRPDIKRGEF SPEEDDTIIK LHALKGNKWA AIATSLAGRT DNEIKNYWNT NLKKRLKQKG
IDAITHKPIN STGQTGFEPK VNKPVYSSGS ARLLNRVASK YAVELNRDLL TGIISGNSTV
AEDSQNSGDV DSPTSTLLNK MAATSVLINT TTTYSGFSDN CSFTDEFNEF FNNEEISDIY
TTVDNFGFME ELKSILSYGD ASAGVIENSP EVNVADAMEF IDSWNEDDNM VGVFV
