MYB36_ARATH
ID MYB36_ARATH Reviewed; 333 AA.
AC Q9FKL2; Q9ZTE6;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Transcription factor MYB36 {ECO:0000303|PubMed:9839469};
DE AltName: Full=Myb-related protein 36 {ECO:0000303|PubMed:9839469};
DE Short=AtMYB36 {ECO:0000303|PubMed:9839469};
GN Name=MYB36 {ECO:0000303|PubMed:9839469};
GN OrderedLocusNames=At5g57620 {ECO:0000312|Araport:AT5G57620};
GN ORFNames=MUA2.20 {ECO:0000312|EMBL:BAB08797.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: A genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP GENE FAMILY.
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [8]
RP TISSUE SPECIFICITY, AND GENE FAMILY.
RX PubMed=16461581; DOI=10.1105/tpc.105.038745;
RA Mueller D., Schmitz G., Theres K.;
RT "Blind homologous R2R3 Myb genes control the pattern of lateral meristem
RT initiation in Arabidopsis.";
RL Plant Cell 18:586-597(2006).
RN [9]
RP GENE FAMILY.
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
RN [10]
RP INDUCTION BY SCR.
RX PubMed=24517883; DOI=10.1111/tpj.12470;
RA Cui H., Kong D., Liu X., Hao Y.;
RT "SCARECROW, SCR-LIKE 23 and SHORT-ROOT control bundle sheath cell fate and
RT function in Arabidopsis thaliana.";
RL Plant J. 78:319-327(2014).
RN [11]
RP FUNCTION, DISRUPTION PHENOTYPE, MUTAGENESIS OF ARG-89, TISSUE SPECIFICITY,
RP AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Columbia;
RX PubMed=26124109; DOI=10.1073/pnas.1507691112;
RA Kamiya T., Borghi M., Wang P., Danku J.M.C., Kalmbach L., Hosmani P.S.,
RA Naseer S., Fujiwara T., Geldner N., Salt D.E.;
RT "The MYB36 transcription factor orchestrates Casparian strip formation.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:10533-10538(2015).
RN [12]
RP FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY SCR, AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Columbia;
RX PubMed=26371322; DOI=10.1073/pnas.1515576112;
RA Liberman L.M., Sparks E.E., Moreno-Risueno M.A., Petricka J.J.,
RA Benfey P.N.;
RT "MYB36 regulates the transition from proliferation to differentiation in
RT the Arabidopsis root.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:12099-12104(2015).
CC -!- FUNCTION: Transcription factors that activates genes required for
CC endodermal differentiation but represses genes involved in
CC proliferative divisions, thus regulating the transition from
CC proliferation to differentiation in root endodermis (PubMed:26371322).
CC Required for Casparian strip formation by positively regulating the
CC expression of the Casparian strip genes CASP1, PER64 and ESB1 and other
CC endodermis-specific genes, thus triggering correct localized lignin
CC biosynthesis in root endodermis and subsequently regulating global ion
CC homeostasis (PubMed:26124109, PubMed:26371322).
CC {ECO:0000269|PubMed:26124109, ECO:0000269|PubMed:26371322}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- TISSUE SPECIFICITY: Expressed in leaves, roots (endodermis-specific)
CC and seedlings. {ECO:0000269|PubMed:16461581,
CC ECO:0000269|PubMed:26124109, ECO:0000269|PubMed:26371322,
CC ECO:0000269|PubMed:9839469}.
CC -!- DEVELOPMENTAL STAGE: In roots, expressed in endodermal cells from the
CC late elongation zones to the differentiation zone and, to a lower
CC extent, in endodermal cells of the meristematic zone.
CC {ECO:0000269|PubMed:26124109, ECO:0000269|PubMed:26371322}.
CC -!- INDUCTION: Directly up-regulated by SCARECROW (SCR), as part of the
CC differentiation program controlled by SHORT-ROOT (SHR).
CC {ECO:0000269|PubMed:24517883, ECO:0000269|PubMed:26371322}.
CC -!- DISRUPTION PHENOTYPE: In myb36-1, myb36-2 and myb36-4, impaired
CC Casparian strips formation replaced by ectopic lignin-like material in
CC the corners of endodermal cells, associated with reduced expression of
CC several endodermis-specific genes and abnormal CASP1 localization in
CC the plasma membrane (PubMed:26124109, PubMed:26371322). Multiple
CC changes to leaf ionome, including elevated concentrations of sodium,
CC magnesium, and zinc and decreased calcium, manganese, and iron. Longer
CC root hairs (PubMed:26124109). Delayed and defective barrier (Casparian
CC strips) formation as well as extra cell divisions in the meristem in
CC roots (PubMed:26371322). {ECO:0000269|PubMed:26124109,
CC ECO:0000269|PubMed:26371322}.
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DR EMBL; AF062878; AAC83600.1; -; mRNA.
DR EMBL; AY519640; AAS10110.1; -; mRNA.
DR EMBL; AB011482; BAB08797.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96926.1; -; Genomic_DNA.
DR EMBL; AK228818; BAF00714.1; -; mRNA.
DR EMBL; BT030331; ABO09894.1; -; mRNA.
DR PIR; T51650; T51650.
DR RefSeq; NP_200570.1; NM_125143.4.
DR AlphaFoldDB; Q9FKL2; -.
DR SMR; Q9FKL2; -.
DR STRING; 3702.AT5G57620.1; -.
DR PaxDb; Q9FKL2; -.
DR PRIDE; Q9FKL2; -.
DR ProteomicsDB; 251386; -.
DR EnsemblPlants; AT5G57620.1; AT5G57620.1; AT5G57620.
DR GeneID; 835866; -.
DR Gramene; AT5G57620.1; AT5G57620.1; AT5G57620.
DR KEGG; ath:AT5G57620; -.
DR Araport; AT5G57620; -.
DR TAIR; locus:2174557; AT5G57620.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_6_2_1; -.
DR InParanoid; Q9FKL2; -.
DR OMA; NPAHEFQ; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q9FKL2; -.
DR PRO; PR:Q9FKL2; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FKL2; baseline and differential.
DR GO; GO:0048226; C:Casparian strip; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IPI:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:TAIR.
DR GO; GO:0030154; P:cell differentiation; IMP:TAIR.
DR GO; GO:0035987; P:endodermal cell differentiation; IMP:UniProtKB.
DR GO; GO:0050801; P:ion homeostasis; IMP:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0045597; P:positive regulation of cell differentiation; IDA:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:2000067; P:regulation of root morphogenesis; IMP:UniProtKB.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..333
FT /note="Transcription factor MYB36"
FT /id="PRO_0000435475"
FT DOMAIN 9..62
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 63..117
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 38..62
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 90..113
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 119..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 89
FT /note="R->W: In myb36-3; impaired accumulation of CASP1 in
FT Casparian strips and longer root hairs."
FT /evidence="ECO:0000269|PubMed:26124109"
FT CONFLICT 157
FT /note="R -> K (in Ref. 1; AAC83600)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 333 AA; 37980 MW; CA296E9C64299240 CRC64;
MGRAPCCDKA NVKKGPWSPE EDVKLKDYID KYGTGGNWIA LPQKIGLKRC GKSCRLRWLN
YLRPNIKHGG FSEEEDRIIL SLYISIGSRW SIIAAQLPGR TDNDIKNYWN TKLKKKLLGR
QKQMNRQDSI TDSTENNLSN NNNNKSPQNL SNSALERLQL HMQLQNLQSP FSSFYNNPIL
WPKLHPLLQS TTTNQNPKLA SQESFHPLGV NVDHQHNNTK LAQINNGASS LYSENVEQSQ
NPAHEFQPNF GFSQDLRLDN HNMDFMNRGV SKELFQVGNE FELTNGSSWW SEEVELERKT
TSSSSWGSAS VLDQTTEGMV MLQDYAQMSY HSV
