MYB3_ARATH
ID MYB3_ARATH Reviewed; 257 AA.
AC Q9S9K9; Q9S7Y2;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Transcription factor MYB3;
DE AltName: Full=Myb-related protein 3;
DE Short=AtMYB3;
GN Name=MYB3; OrderedLocusNames=At1g22640; ORFNames=F12K8.1, T22J18.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 7-257, TISSUE SPECIFICITY, AND INDUCTION BY
RP NITROGEN.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 12-257.
RA Qu L.-J., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [7]
RP GENE FAMILY, AND INDUCTION BY ABA; SA AND HIGH SALT.
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
RN [8]
RP INTERACTION WITH CPL1, SUBCELLULAR LOCATION, AND INDUCTION BY ABA.
RX PubMed=18541146; DOI=10.1016/j.bbrc.2008.05.161;
RA Bang W.Y., Kim S.W., Jeong I.S., Koiwa H., Bahk J.D.;
RT "The C-terminal region (640-967) of Arabidopsis CPL1 interacts with the
RT abiotic stress- and ABA-responsive transcription factors.";
RL Biochem. Biophys. Res. Commun. 372:907-912(2008).
CC -!- SUBUNIT: Interacts with CPL1. {ECO:0000269|PubMed:18541146}.
CC -!- INTERACTION:
CC Q9S9K9; Q17TI5: BRX; NbExp=3; IntAct=EBI-1786591, EBI-4426649;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:18541146}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, stems, leaves, flowers and
CC siliques. {ECO:0000269|PubMed:9839469}.
CC -!- INDUCTION: By nitrogen, salicylic acid, NaCl and abscisic acid (ABA).
CC {ECO:0000269|PubMed:16463103, ECO:0000269|PubMed:18541146,
CC ECO:0000269|PubMed:9839469}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF18515.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC003979; AAC25522.1; -; Genomic_DNA.
DR EMBL; AC006551; AAF18515.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002684; AEE30263.1; -; Genomic_DNA.
DR EMBL; AY072543; AAL60051.1; -; mRNA.
DR EMBL; BT000841; AAN38678.1; -; mRNA.
DR EMBL; AF062859; AAC83581.1; -; mRNA.
DR EMBL; AY519557; AAS10027.1; -; mRNA.
DR PIR; T00780; T00780.
DR PIR; T51631; T51631.
DR RefSeq; NP_564176.2; NM_102111.4.
DR AlphaFoldDB; Q9S9K9; -.
DR SMR; Q9S9K9; -.
DR BioGRID; 24109; 9.
DR IntAct; Q9S9K9; 8.
DR STRING; 3702.AT1G22640.1; -.
DR PaxDb; Q9S9K9; -.
DR PRIDE; Q9S9K9; -.
DR ProteomicsDB; 251259; -.
DR EnsemblPlants; AT1G22640.1; AT1G22640.1; AT1G22640.
DR GeneID; 838870; -.
DR Gramene; AT1G22640.1; AT1G22640.1; AT1G22640.
DR KEGG; ath:AT1G22640; -.
DR Araport; AT1G22640; -.
DR TAIR; locus:2009452; AT1G22640.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_23_2_1; -.
DR InParanoid; Q9S9K9; -.
DR OMA; EEDCVLN; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q9S9K9; -.
DR PRO; PR:Q9S9K9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9S9K9; baseline and differential.
DR Genevisible; Q9S9K9; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0009800; P:cinnamic acid biosynthetic process; TAS:TAIR.
DR GO; GO:0009892; P:negative regulation of metabolic process; TAS:TAIR.
DR GO; GO:0009611; P:response to wounding; IEP:TAIR.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..257
FT /note="Transcription factor MYB3"
FT /id="PRO_0000376087"
FT DOMAIN 9..61
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 62..116
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 37..61
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 89..112
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT MOTIF 189..193
FT /note="Required for interaction with CPL1"
FT CONFLICT 7..9
FT /note="CEK -> HAS (in Ref. 4; AAC83581)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 257 AA; 29352 MW; 132D80DEA58D7D93 CRC64;
MGRSPCCEKA HMNKGAWTKE EDQLLVDYIR KHGEGCWRSL PRAAGLQRCG KSCRLRWMNY
LRPDLKRGNF TEEEDELIIK LHSLLGNKWS LIAGRLPGRT DNEIKNYWNT HIKRKLLSRG
IDPNSHRLIN ESVVSPSSLQ NDVVETIHLD FSGPVKPEPV REEIGMVNNC ESSGTTSEKD
YGNEEDWVLN LELSVGPSYR YESTRKVSVV DSAESTRRWG SELFGAHESD AVCLCCRIGL
FRNESCRNCR VSDVRTH
