ID   MYB3_CROXC              Reviewed;         259 AA.
AC   A0A4D6QCQ2;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   03-JUL-2019, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Transcription factor MYB3 {ECO:0000305};
DE   AltName: Full=Myb-related protein 3 {ECO:0000303|PubMed:31004005};
DE            Short=CcMYB3 {ECO:0000303|PubMed:31004005};
GN   Name=MYB3 {ECO:0000303|PubMed:31004005};
OS   Crocosmia x crocosmiiflora (Montbretia) (Crocosmia aurea x Crocosmia
OS   pottsii).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Asparagales; Iridaceae;
OC   Crocoideae; Freesieae; Crocosmia.
OX   NCBI_TaxID=1053288;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX   PubMed=31004005; DOI=10.1104/pp.19.00254;
RA   Irmisch S., Ruebsam H., Jancsik S., Man Saint Yuen M., Madilao L.L.,
RA   Bohlmann J.;
RT   "Flavonol biosynthesis genes and their use in engineering the plant
RT   antidiabetic metabolite montbretin A.";
RL   Plant Physiol. 180:1277-1290(2019).
CC   -!- FUNCTION: Transcription activator involved in the spatiotemporal
CC       regulation of flavonoid biosynthesis specifically in the corms of
CC       Montbretia (PubMed:31004005). Activates the promoters of enzymes
CC       involved in the biosynthesis of the flavonol myricetin and the
CC       flavonol-glycoside montbretin A (MbA) (PubMed:31004005). MbA is a
CC       potent inhibitor of human pancreatic alpha-amylase and is being
CC       developed as drug candidate to treat type-2 diabetes (PubMed:31004005).
CC       {ECO:0000269|PubMed:31004005}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
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DR   EMBL; MK562527; QCF41222.1; -; mRNA.
DR   AlphaFoldDB; A0A4D6QCQ2; -.
DR   SMR; A0A4D6QCQ2; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00167; SANT; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   Pfam; PF00249; Myb_DNA-binding; 2.
DR   SMART; SM00717; SANT; 2.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS51294; HTH_MYB; 2.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..259
FT                   /note="Transcription factor MYB3"
FT                   /id="PRO_0000448215"
FT   DOMAIN          12..64
FT                   /note="HTH myb-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DOMAIN          65..119
FT                   /note="HTH myb-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DNA_BIND        40..64
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DNA_BIND        92..115
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   REGION          129..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   259 AA;  29699 MW;  32F98F93DB1D3041 CRC64;
     MVKRSQRVGK KAVEVNRGTW TAEEDEKLMN YVSAHGDKKW RMLPAKAGLK RCGKSCRLRW
     LNYLRPGIKR GNISEDEEDL IIRLHNLLGN RWSIIAGRIP GRTDNEIKNH WNTHLSKRSL
     TIDDLNNKQN PGLDNRDMLS PTKITQRSTP THTNKNTNDE LIDSWTDLPA PDFDLEQFLS
     LLPMSDLCPG SNGNDLELND FGIPINDINQ DSFRSDDYNV NYQEFLDSQV WSRAFEFDDI
     DQFLDCQAYG SLCSPIAGQ