MYB48_ARATH
ID MYB48_ARATH Reviewed; 256 AA.
AC Q9LX82; Q4JL82; Q67YJ3;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Transcription factor MYB48;
DE AltName: Full=Myb-related protein 48;
DE Short=AtMYB48;
GN Name=MYB48; OrderedLocusNames=At3g46130; ORFNames=F12M12.100;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM MYB48-3), GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MYB48-1; MYB48-2; MYB48-3 AND
RP MYB48-4), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND ALTERNATIVE
RP SPLICING.
RC STRAIN=cv. Columbia;
RX PubMed=16531467; DOI=10.1093/jxb/erj094;
RA Li J., Li X., Guo L., Lu F., Feng X., He K., Wei L., Chen Z., Qu L.-J.,
RA Gu H.;
RT "A subgroup of MYB transcription factor genes undergoes highly conserved
RT alternative splicing in Arabidopsis and rice.";
RL J. Exp. Bot. 57:1263-1273(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM MYB48-1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP INDUCTION BY SALICYLIC ACID, AND GENE FAMILY.
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
CC -!- FUNCTION: Transcription factor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:16531467}. Note=Isoform MYB48-2 and isoform MYB48-3
CC (harboring both NLS1 and NLS2) are nuclear, werheas isoform MYB48-1
CC (harboring NLS2) and isoform MYB48-4 (harboring NLS1) are partially
CC nuclear.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=MYB48-3;
CC IsoId=Q9LX82-1; Sequence=Displayed;
CC Name=MYB48-1;
CC IsoId=Q9LX82-2; Sequence=VSP_018289;
CC Name=MYB48-2;
CC IsoId=Q9LX82-3; Sequence=VSP_018288;
CC Name=MYB48-4;
CC IsoId=Q9LX82-4; Sequence=VSP_018290;
CC -!- TISSUE SPECIFICITY: Mainly expressed in leaves and seedlings, and to a
CC lower extent, in roots, stems and inflorescences. Isoform MYB48-1,
CC isoform MYB48-3 and isoform MYB48-4 are present in all of these organs,
CC but isoform MYB48-2 is confined to leaves.
CC {ECO:0000269|PubMed:16531467}.
CC -!- INDUCTION: By salicylic acid (SA). {ECO:0000269|PubMed:16463103}.
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DR EMBL; AF272733; AAG01294.1; -; mRNA.
DR EMBL; AY519594; AAS10064.1; -; mRNA.
DR EMBL; DQ075255; AAY97897.1; -; mRNA.
DR EMBL; DQ075256; AAY97898.1; -; mRNA.
DR EMBL; DQ075257; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL355775; CAB90940.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78118.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78119.1; -; Genomic_DNA.
DR EMBL; AK176475; BAD44238.1; -; mRNA.
DR PIR; T49254; T49254.
DR RefSeq; NP_001030816.1; NM_001035739.2. [Q9LX82-2]
DR RefSeq; NP_001078249.1; NM_001084780.1. [Q9LX82-3]
DR AlphaFoldDB; Q9LX82; -.
DR SMR; Q9LX82; -.
DR BioGRID; 9076; 1.
DR STRING; 3702.AT3G46130.1; -.
DR PaxDb; Q9LX82; -.
DR PRIDE; Q9LX82; -.
DR EnsemblPlants; AT3G46130.1; AT3G46130.1; AT3G46130.
DR EnsemblPlants; AT3G46130.2; AT3G46130.2; AT3G46130. [Q9LX82-2]
DR EnsemblPlants; AT3G46130.3; AT3G46130.3; AT3G46130. [Q9LX82-3]
DR GeneID; 823756; -.
DR Gramene; AT3G46130.1; AT3G46130.1; AT3G46130.
DR Gramene; AT3G46130.2; AT3G46130.2; AT3G46130. [Q9LX82-2]
DR Gramene; AT3G46130.3; AT3G46130.3; AT3G46130. [Q9LX82-3]
DR KEGG; ath:AT3G46130; -.
DR Araport; AT3G46130; -.
DR TAIR; locus:2075236; AT3G46130.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_25_0_1; -.
DR InParanoid; Q9LX82; -.
DR OMA; LWRMEDE; -.
DR PhylomeDB; Q9LX82; -.
DR PRO; PR:Q9LX82; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LX82; baseline and differential.
DR Genevisible; Q9LX82; AT.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR044676; EOBI/EOBII-like_plant.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR45675; PTHR45675; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation.
FT CHAIN 1..256
FT /note="Transcription factor MYB48"
FT /id="PRO_0000234358"
FT DOMAIN 4..56
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 57..111
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 32..56
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 84..107
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 108..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 61..64
FT /note="Bipartite nuclear localization signal 1"
FT /evidence="ECO:0000255"
FT MOTIF 108..116
FT /note="Bipartite nuclear localization signal 2"
FT /evidence="ECO:0000255"
FT COMPBIAS 117..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..166
FT /note="Missing (in isoform MYB48-4)"
FT /evidence="ECO:0000303|PubMed:16531467"
FT /id="VSP_018290"
FT VAR_SEQ 1..64
FT /note="Missing (in isoform MYB48-1)"
FT /evidence="ECO:0000303|PubMed:16531467, ECO:0000303|Ref.5"
FT /id="VSP_018289"
FT VAR_SEQ 2..38
FT /note="MQEEGNRKGPWTEQEDILLVNFVHLFGDRRWDFIAKV -> DRTGRHT (in
FT isoform MYB48-2)"
FT /evidence="ECO:0000303|PubMed:16531467"
FT /id="VSP_018288"
SQ SEQUENCE 256 AA; 29654 MW; A872DFB58AC8379F CRC64;
MMQEEGNRKG PWTEQEDILL VNFVHLFGDR RWDFIAKVSG LNRTGKSCRL RWVNYLHPGL
KRGKMTPQEE RLVLELHAKW GNRWSKIARK LPGRTDNEIK NYWRTHMRKK AQEKKRPVSP
TSSFSNCSSS SVTTTTTNTQ DTSCHSRKSS GEVSFYDTGG SRSTREMNQE NEDVYSLDDI
WREIDHSAVN IIKPVKDIYS EQSHCLSYPN LASPSWESSL DSIWNMDADK SKISSYFAND
QFPFCFQHSR SPWSSG
