MYB4_CROXC
ID MYB4_CROXC Reviewed; 260 AA.
AC A0A4D6Q5I0;
DT 16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT 03-JUL-2019, sequence version 1.
DT 25-MAY-2022, entry version 10.
DE RecName: Full=Transcription factor MYB4 {ECO:0000305};
DE AltName: Full=Myb-related protein 4 {ECO:0000303|PubMed:31004005};
DE Short=CcMYB4 {ECO:0000303|PubMed:31004005};
GN Name=MYB4 {ECO:0000303|PubMed:31004005};
OS Crocosmia x crocosmiiflora (Montbretia) (Crocosmia aurea x Crocosmia
OS pottsii).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Asparagales; Iridaceae;
OC Crocoideae; Freesieae; Crocosmia.
OX NCBI_TaxID=1053288;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=31004005; DOI=10.1104/pp.19.00254;
RA Irmisch S., Ruebsam H., Jancsik S., Man Saint Yuen M., Madilao L.L.,
RA Bohlmann J.;
RT "Flavonol biosynthesis genes and their use in engineering the plant
RT antidiabetic metabolite montbretin A.";
RL Plant Physiol. 180:1277-1290(2019).
CC -!- FUNCTION: Transcription activator involved in the spatiotemporal
CC regulation of flavonoid biosynthesis specifically in the corms of
CC Montbretia (PubMed:31004005). Activates the promoters of enzymes
CC involved in the biosynthesis of the flavonol myricetin and the
CC flavonol-glycoside montbretin A (MbA) (PubMed:31004005). MbA is a
CC potent inhibitor of human pancreatic alpha-amylase and is being
CC developed as drug candidate to treat type-2 diabetes (PubMed:31004005).
CC {ECO:0000269|PubMed:31004005}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
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DR EMBL; MK562528; QCF41223.1; -; mRNA.
DR AlphaFoldDB; A0A4D6Q5I0; -.
DR SMR; A0A4D6Q5I0; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..260
FT /note="Transcription factor MYB4"
FT /id="PRO_0000448216"
FT DOMAIN 12..64
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 65..119
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 40..64
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 92..115
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
SQ SEQUENCE 260 AA; 29821 MW; EDF978F8D029D00B CRC64;
MVKRSQRVEK KAVEVNRGTW TAEEDEKLMN YVSAHGDKKW RMLPAKAGLK RCGKSCRLRW
LNYLRPGIKR GNISEDEEDL IIRLHNLLGN RWSIIAGRIP GRTDNEIKNH WNTHLSKRSL
TIEDLNKKHN PGIDNIDILP PTKITLTSSS DTFPVTPVCQ TDQASDTNKN DVLVDSWTDL
SGPDFDLEQF LSLLPMSDLC PGSNGNELEF DDFGIPRHDS KQDSFRSNDY NINYQECLDS
QVWSCAFEYD DLDQFLDCQS