MYB52_ARATH
ID MYB52_ARATH Reviewed; 249 AA.
AC Q6R0C4; Q8LCC8; Q9LMT5; Q9ZTD9;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Transcription factor MYB52 {ECO:0000303|PubMed:9839469};
DE AltName: Full=Myb-related protein 52 {ECO:0000303|PubMed:9839469};
DE Short=AtMYB52 {ECO:0000303|PubMed:9839469};
DE AltName: Full=Protein ABA-HYPERSENSITIVE 1 {ECO:0000303|PubMed:21399993};
GN Name=MYB52 {ECO:0000303|PubMed:9839469};
GN Synonyms=AHS1 {ECO:0000303|PubMed:21399993};
GN OrderedLocusNames=At1g17950 {ECO:0000312|Araport:AT1G17950};
GN ORFNames=F2H15.17 {ECO:0000312|EMBL:AAF97274.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: A genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY.
RX PubMed=9628022; DOI=10.1046/j.1365-313x.1998.00113.x;
RA Romero I., Fuertes A., Benito M.J., Malpica J.M., Leyva A., Paz-Ares J.;
RT "More than 80 R2R3-MYB regulatory genes in the genome of Arabidopsis
RT thaliana.";
RL Plant J. 14:273-284(1998).
RN [7]
RP INDUCTION BY ABSCISIC ACID.
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
RN [8]
RP FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=18952777; DOI=10.1105/tpc.108.061325;
RA Zhong R., Lee C., Zhou J., McCarthy R.L., Ye Z.H.;
RT "A battery of transcription factors involved in the regulation of secondary
RT cell wall biosynthesis in Arabidopsis.";
RL Plant Cell 20:2763-2782(2008).
RN [9]
RP INDUCTION BY MYB46.
RX PubMed=19674407; DOI=10.1111/j.1365-313x.2009.03989.x;
RA Ko J.H., Kim W.C., Han K.H.;
RT "Ectopic expression of MYB46 identifies transcriptional regulatory genes
RT involved in secondary wall biosynthesis in Arabidopsis.";
RL Plant J. 60:649-665(2009).
RN [10]
RP TISSUE SPECIFICITY.
RX PubMed=19325888; DOI=10.1371/journal.pgen.1000440;
RA Cheng H., Song S., Xiao L., Soo H.M., Cheng Z., Xie D., Peng J.;
RT "Gibberellin acts through jasmonate to control the expression of MYB21,
RT MYB24, and MYB57 to promote stamen filament growth in Arabidopsis.";
RL PLoS Genet. 5:E1000440-E1000440(2009).
RN [11]
RP FUNCTION, TISSUE SPECIFICITY, AND INDUCTION BY ABSCISIC ACID AND SALT.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX PubMed=21399993; DOI=10.1007/s10059-011-0300-7;
RA Park M.Y., Kang J.-Y., Kim S.Y.;
RT "Overexpression of AtMYB52 confers ABA hypersensitivity and drought
RT tolerance.";
RL Mol. Cells 31:447-454(2011).
RN [12]
RP INDUCTION BY MYB46 AND MYB83.
RX PubMed=22197883; DOI=10.1093/pcp/pcr185;
RA Zhong R., Ye Z.H.;
RT "MYB46 and MYB83 bind to the SMRE sites and directly activate a suite of
RT transcription factors and secondary wall biosynthetic genes.";
RL Plant Cell Physiol. 53:368-380(2012).
RN [13]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=23781226; DOI=10.3389/fpls.2013.00189;
RA Cassan-Wang H., Goue N., Saidi M.N., Legay S., Sivadon P., Goffner D.,
RA Grima-Pettenati J.;
RT "Identification of novel transcription factors regulating secondary cell
RT wall formation in Arabidopsis.";
RL Front. Plant Sci. 4:189-189(2013).
CC -!- FUNCTION: Transcription factor that confers sensitivity to abscisic
CC acid (ABA) and salt, but tolerance to drought (PubMed:21399993).
CC Regulates secondary cell wall (SCW) biosynthesis, especially in
CC interfascicular and xylary fibers (PubMed:18952777, PubMed:23781226).
CC {ECO:0000269|PubMed:18952777, ECO:0000269|PubMed:21399993,
CC ECO:0000269|PubMed:23781226}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:18952777}.
CC -!- TISSUE SPECIFICITY: Expressed in stamen (PubMed:19325888). Present in
CC roots and siliques, and, at low levels, in leaves and flowers
CC (PubMed:21399993). Expressed in stems, especially in fibers and, at
CC lower levels, in xylems (PubMed:18952777, PubMed:21399993).
CC {ECO:0000269|PubMed:18952777, ECO:0000269|PubMed:19325888,
CC ECO:0000269|PubMed:21399993}.
CC -!- INDUCTION: By abscisic acid (PubMed:16463103, PubMed:21399993).
CC Accumulates in response to salt (PubMed:21399993). Triggered by MYB46
CC and MYB83 in the regulation of secondary cell wall biosynthesis
CC (PubMed:19674407, PubMed:22197883). {ECO:0000269|PubMed:16463103,
CC ECO:0000269|PubMed:19674407, ECO:0000269|PubMed:21399993,
CC ECO:0000269|PubMed:22197883}.
CC -!- DISRUPTION PHENOTYPE: Secondary cell wall (SCW) defects including
CC severe reduction in SCW thickening in both interfascicular fibers and
CC xylary fibers of inflorescence stems (PubMed:18952777). Hyperlignified
CC SCW in interfascicular fibers and xylary fibers (PubMed:23781226).
CC {ECO:0000269|PubMed:18952777, ECO:0000269|PubMed:23781226}.
CC -!- CAUTION: Has been reported as both positive and negative regulator of
CC secondary cell wall (SCW) biosynthesis by contradictory mutants
CC phenotypes. {ECO:0000269|PubMed:18952777, ECO:0000269|PubMed:23781226}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF97274.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF062888; AAC83610.1; -; mRNA.
DR EMBL; AY519554; AAS10024.1; -; mRNA.
DR EMBL; AC034106; AAF97274.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002684; AEE29655.1; -; Genomic_DNA.
DR EMBL; AY086672; AAM63729.1; -; mRNA.
DR PIR; G86314; G86314.
DR PIR; T51660; T51660.
DR RefSeq; NP_173237.1; NM_101658.3.
DR AlphaFoldDB; Q6R0C4; -.
DR SMR; Q6R0C4; -.
DR IntAct; Q6R0C4; 14.
DR STRING; 3702.AT1G17950.1; -.
DR PaxDb; Q6R0C4; -.
DR PRIDE; Q6R0C4; -.
DR ProteomicsDB; 251003; -.
DR EnsemblPlants; AT1G17950.1; AT1G17950.1; AT1G17950.
DR GeneID; 838374; -.
DR Gramene; AT1G17950.1; AT1G17950.1; AT1G17950.
DR KEGG; ath:AT1G17950; -.
DR Araport; AT1G17950; -.
DR TAIR; locus:2030903; AT1G17950.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_18_1_1; -.
DR InParanoid; Q6R0C4; -.
DR OMA; TIDINYP; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q6R0C4; -.
DR PRO; PR:Q6R0C4; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q6R0C4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:1901347; P:negative regulation of secondary cell wall biogenesis; IMP:UniProtKB.
DR GO; GO:0009834; P:plant-type secondary cell wall biogenesis; IMP:UniProtKB.
DR GO; GO:1901348; P:positive regulation of secondary cell wall biogenesis; IMP:UniProtKB.
DR GO; GO:2000652; P:regulation of secondary cell wall biogenesis; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0009737; P:response to abscisic acid; IMP:UniProtKB.
DR GO; GO:1902074; P:response to salt; IMP:UniProtKB.
DR GO; GO:0009414; P:response to water deprivation; IMP:UniProtKB.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 2: Evidence at transcript level;
KW Cell wall biogenesis/degradation; DNA-binding; Nucleus; Reference proteome;
KW Repeat; Stress response; Transcription; Transcription regulation.
FT CHAIN 1..249
FT /note="Transcription factor MYB52"
FT /id="PRO_0000438733"
FT DOMAIN 1..55
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 56..106
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 28..51
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 79..102
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT CONFLICT 71
FT /note="S -> P (in Ref. 1; AAC83610)"
FT /evidence="ECO:0000305"
FT CONFLICT 165
FT /note="F -> S (in Ref. 1; AAC83610)"
FT /evidence="ECO:0000305"
FT CONFLICT 168
FT /note="G -> V (in Ref. 5; AAM63729)"
FT /evidence="ECO:0000305"
FT CONFLICT 227
FT /note="P -> R (in Ref. 1; AAC83610)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 249 AA; 28925 MW; 6CBED3213C0906D8 CRC64;
MMCSRGHWRP AEDEKLRELV EQFGPHNWNA IAQKLSGRSG KSCRLRWFNQ LDPRINRNPF
TEEEEERLLA SHRIHGNRWS VIARFFPGRT DNAVKNHWHV IMARRGRERS KLRPRGLGHD
GTVAATGMIG NYKDCDKERR LATTTAINFP YQFSHINHFQ VLKEFLTGKI GFRNSTTPIQ
EGAIDQTKRP MEFYNFLQVN TDSKIHELID NSRKDEEEDV DQNNRIPNEN CVPFFDFLSV
GNSASQGLC
