MYB58_ARATH
ID MYB58_ARATH Reviewed; 274 AA.
AC Q9SA47; Q8LEE5; Q9ZTD4;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Transcription factor MYB58 {ECO:0000303|PubMed:11597504};
DE AltName: Full=Myb-related protein 58 {ECO:0000303|PubMed:11597504};
DE Short=AtMYB58 {ECO:0000303|PubMed:11597504};
GN Name=MYB58 {ECO:0000303|PubMed:11597504};
GN OrderedLocusNames=At1g16490 {ECO:0000312|Araport:AT1G16490};
GN ORFNames=F3O9.29 {ECO:0000312|EMBL:AAD34700.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Fujita M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 73-273, TISSUE SPECIFICITY, INDUCTION BY
RP LIGHT, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [7]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP INDUCTION BY SND1 CLOSE HOMOLOGS, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=19122102; DOI=10.1105/tpc.108.063321;
RA Zhou J., Lee C., Zhong R., Ye Z.-H.;
RT "MYB58 and MYB63 are transcriptional activators of the lignin biosynthetic
RT pathway during secondary cell wall formation in Arabidopsis.";
RL Plant Cell 21:248-266(2009).
RN [8]
RP REVIEW.
RX PubMed=19838072; DOI=10.4161/psb.4.11.9875;
RA Zhong R., Ye Z.H.;
RT "Transcriptional regulation of lignin biosynthesis.";
RL Plant Signal. Behav. 4:1028-1034(2009).
RN [9]
RP INDUCTION BY MYB46 AND MYB83.
RX PubMed=22197883; DOI=10.1093/pcp/pcr185;
RA Zhong R., Ye Z.H.;
RT "MYB46 and MYB83 bind to the SMRE sites and directly activate a suite of
RT transcription factors and secondary wall biosynthetic genes.";
RL Plant Cell Physiol. 53:368-380(2012).
CC -!- FUNCTION: Transcriptional activator that binds DNA to the AC cis-
CC elements 5'-ACCTACC-3', 5'-ACCAACC-3' and 5'-ACCTAAC-3' of promoters
CC and specifically activates lignin biosynthetic genes during secondary
CC wall formation mediated by SND1. {ECO:0000269|PubMed:19122102}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:19122102}.
CC -!- TISSUE SPECIFICITY: Expressed in leaves (PubMed:9839469). Specifically
CC expressed in fibers and vessels undergoing secondary wall thickening,
CC especially in inflorescence stems (PubMed:19122102).
CC {ECO:0000269|PubMed:19122102, ECO:0000269|PubMed:9839469}.
CC -!- DEVELOPMENTAL STAGE: In nonelongating internodes, highly expressed in
CC interfascicular fibers and xylem cells but not in parenchymatous pith
CC cells. In elongating internodes, predominantly expressed in protoxylem
CC vessels. {ECO:0000269|PubMed:19122102}.
CC -!- INDUCTION: Slightly induced by light (PubMed:9839469). Regulated by the
CC SND1 close homologs NST1, NST2, VND6, and VND7 and their downstream
CC targets MYB46 and MYB83 (PubMed:19122102, PubMed:22197883).
CC {ECO:0000269|PubMed:19122102, ECO:0000269|PubMed:22197883,
CC ECO:0000269|PubMed:9839469}.
CC -!- DISRUPTION PHENOTYPE: Reduction in secondary wall thickening and lignin
CC content. {ECO:0000269|PubMed:19122102}.
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DR EMBL; AB493459; BAH30297.1; -; mRNA.
DR EMBL; AC006341; AAD34700.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29461.1; -; Genomic_DNA.
DR EMBL; AY085461; AAM62687.1; -; mRNA.
DR EMBL; AF062893; AAC83615.1; -; mRNA.
DR PIR; D86300; D86300.
DR PIR; T51665; T51665.
DR RefSeq; NP_173098.1; NM_101514.3.
DR AlphaFoldDB; Q9SA47; -.
DR SMR; Q9SA47; -.
DR IntAct; Q9SA47; 1.
DR STRING; 3702.AT1G16490.1; -.
DR PaxDb; Q9SA47; -.
DR PRIDE; Q9SA47; -.
DR EnsemblPlants; AT1G16490.1; AT1G16490.1; AT1G16490.
DR GeneID; 838219; -.
DR Gramene; AT1G16490.1; AT1G16490.1; AT1G16490.
DR KEGG; ath:AT1G16490; -.
DR Araport; AT1G16490; -.
DR TAIR; locus:2032860; AT1G16490.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_6_2_1; -.
DR InParanoid; Q9SA47; -.
DR OMA; FQYLEGH; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q9SA47; -.
DR PRO; PR:Q9SA47; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SA47; differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0009809; P:lignin biosynthetic process; IMP:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:TAIR.
DR GO; GO:2000652; P:regulation of secondary cell wall biogenesis; IMP:TAIR.
DR GO; GO:0009416; P:response to light stimulus; IEP:UniProtKB.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Lignin biosynthesis; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation.
FT CHAIN 1..274
FT /note="Transcription factor MYB58"
FT /id="PRO_0000438719"
FT DOMAIN 11..63
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 64..118
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 39..63
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 91..114
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 121..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 225
FT /note="E -> D (in Ref. 4; AAM62687)"
FT /evidence="ECO:0000305"
FT CONFLICT 247..248
FT /note="Missing (in Ref. 4; AAM62687)"
FT /evidence="ECO:0000305"
FT CONFLICT 247
FT /note="Missing (in Ref. 5; AAC83615)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 274 AA; 31461 MW; FBB8DA959FA1BDCD CRC64;
MGKGRAPCCD KTKVKRGPWS HDEDLKLISF IHKNGHENWR SLPKQAGLLR CGKSCRLRWI
NYLRPDVKRG NFSAEEEDTI IKLHQSFGNK WSKIASKLPG RTDNEIKNVW HTHLKKRLSS
ETNLNADEAG SKGSLNEEEN SQESSPNASM SFAGSNISSK DDDAQISQMF EHILTYSEFT
GMLQEVDKPE LLEMPFDLDP DIWSFIDGSD SFQQPENRAL QESEEDEVDK WFKHLESELG
LEENDNQQQQ QQHKQGTEDE HSSSLLESYE LLIH
