MYB59_ARATH
ID MYB59_ARATH Reviewed; 235 AA.
AC Q4JL84; O50069; Q0WPL8; Q4JL85; Q4JL86; Q7DLH5; Q9FN86;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Transcription factor MYB59;
DE AltName: Full=Myb-related protein 59;
DE Short=AtMYB59;
GN Name=MYB59; OrderedLocusNames=At5g59780; ORFNames=MTH12.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM MYB59-3).
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MYB59-1; MYB59-2; MYB59-3 AND
RP MYB59-4), TISSUE SPECIFICITY, INDUCTION, SUBCELLULAR LOCATION, AND
RP ALTERNATIVE SPLICING.
RC STRAIN=cv. Columbia;
RX PubMed=16531467; DOI=10.1093/jxb/erj094;
RA Li J., Li X., Guo L., Lu F., Feng X., He K., Wei L., Chen Z., Qu L.-J.,
RA Gu H.;
RT "A subgroup of MYB transcription factor genes undergoes highly conserved
RT alternative splicing in Arabidopsis and rice.";
RL J. Exp. Bot. 57:1263-1273(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9405937; DOI=10.1093/dnares/4.4.291;
RA Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence
RT features of the regions of 1,044,062 bp covered by thirteen physically
RT assigned P1 clones.";
RL DNA Res. 4:291-300(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM MYB59-1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 51-95 (ISOFORMS MYB59-2/MYB59-3).
RC STRAIN=cv. Landsberg erecta;
RX PubMed=9628022; DOI=10.1046/j.1365-313x.1998.00113.x;
RA Romero I., Fuertes A., Benito M.J., Malpica J.M., Leyva A., Paz-Ares J.;
RT "More than 80 R2R3-MYB regulatory genes in the genome of Arabidopsis
RT thaliana.";
RL Plant J. 14:273-284(1998).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [8]
RP INDUCTION BY SALICYLIC ACID AND CADMIUM, AND GENE FAMILY.
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
CC -!- FUNCTION: Transcription factor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:16531467}. Note=Isoform MYB59-2 and isoform MYB59-3
CC (harboring both NLS1 and NLS2) are nuclear, werheas isoform MYB59-1
CC (harboring NLS2) and isoform MYB59-4 (harboring NLS1) are partially
CC nuclear.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=MYB59-3;
CC IsoId=Q4JL84-1; Sequence=Displayed;
CC Name=MYB59-1;
CC IsoId=Q4JL84-2; Sequence=VSP_018291;
CC Name=MYB59-2;
CC IsoId=Q4JL84-3; Sequence=VSP_018292;
CC Name=MYB59-4;
CC IsoId=Q4JL84-4; Sequence=VSP_018293;
CC -!- TISSUE SPECIFICITY: Mainly expressed in leaves and seedlings, and to a
CC lower extent, in roots, stems and inflorescences. Isoform MYB59-1 and
CC isoform MYB59-2 are present in roots, leaves, and seedlings, while the
CC expression of isoform MYB59-3 and isoform MYB59-4 is confined to
CC seedlings. {ECO:0000269|PubMed:16531467}.
CC -!- INDUCTION: Isoform MYB59-1 is induced by jasmonate (JA), salicylic acid
CC (SA), gibberellic acid (GA), and ethylene. Also induced by cadmium
CC (Cd). {ECO:0000269|PubMed:16463103, ECO:0000269|PubMed:16531467}.
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DR EMBL; AF062894; AAC83616.1; -; mRNA.
DR EMBL; AY519641; AAS10111.1; -; mRNA.
DR EMBL; DQ075252; AAY97894.1; -; mRNA.
DR EMBL; DQ075253; AAY97895.1; -; mRNA.
DR EMBL; DQ075254; AAY97896.1; -; mRNA.
DR EMBL; AB006705; BAB09515.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97231.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97232.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97233.1; -; Genomic_DNA.
DR EMBL; AK229048; BAF00931.1; -; mRNA.
DR EMBL; Z95781; CAB09213.1; -; mRNA.
DR EMBL; Z95772; CAB09204.1; -; mRNA.
DR PIR; T51666; T51666.
DR RefSeq; NP_200786.1; NM_125370.4. [Q4JL84-1]
DR RefSeq; NP_851225.1; NM_180894.4. [Q4JL84-2]
DR RefSeq; NP_851226.1; NM_180895.3. [Q4JL84-3]
DR AlphaFoldDB; Q4JL84; -.
DR SMR; Q4JL84; -.
DR STRING; 3702.AT5G59780.3; -.
DR PaxDb; Q4JL84; -.
DR PRIDE; Q4JL84; -.
DR EnsemblPlants; AT5G59780.1; AT5G59780.1; AT5G59780. [Q4JL84-2]
DR EnsemblPlants; AT5G59780.2; AT5G59780.2; AT5G59780. [Q4JL84-3]
DR EnsemblPlants; AT5G59780.3; AT5G59780.3; AT5G59780. [Q4JL84-1]
DR GeneID; 836099; -.
DR Gramene; AT5G59780.1; AT5G59780.1; AT5G59780. [Q4JL84-2]
DR Gramene; AT5G59780.2; AT5G59780.2; AT5G59780. [Q4JL84-3]
DR Gramene; AT5G59780.3; AT5G59780.3; AT5G59780. [Q4JL84-1]
DR KEGG; ath:AT5G59780; -.
DR Araport; AT5G59780; -.
DR TAIR; locus:2174324; AT5G59780.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_25_0_1; -.
DR InParanoid; Q4JL84; -.
DR OMA; HEQSSLQ; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q4JL84; -.
DR PRO; PR:Q4JL84; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q4JL84; baseline and differential.
DR Genevisible; Q4JL84; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IPI:TAIR.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0035865; P:cellular response to potassium ion; IMP:TAIR.
DR GO; GO:0043266; P:regulation of potassium ion transport; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR044676; EOBI/EOBII-like_plant.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR45675; PTHR45675; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation.
FT CHAIN 1..235
FT /note="Transcription factor MYB59"
FT /id="PRO_0000234359"
FT DOMAIN 5..57
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 58..112
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 33..57
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 85..108
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 109..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 62..65
FT /note="Bipartite nuclear localization signal 1"
FT /evidence="ECO:0000255"
FT MOTIF 109..117
FT /note="Bipartite nuclear localization signal 2"
FT /evidence="ECO:0000255"
FT COMPBIAS 118..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..65
FT /note="Missing (in isoform MYB59-1)"
FT /evidence="ECO:0000303|PubMed:16531467, ECO:0000303|Ref.5"
FT /id="VSP_018291"
FT VAR_SEQ 2..40
FT /note="KLVQEEYRKGPWTEQEDILLVNFVHLFGDRRWDFVAKVS -> GFCSESFRF
FT EGGGRNIRI (in isoform MYB59-2)"
FT /evidence="ECO:0000303|PubMed:16531467"
FT /id="VSP_018292"
FT VAR_SEQ 67..215
FT /note="Missing (in isoform MYB59-4)"
FT /evidence="ECO:0000303|PubMed:16531467"
FT /id="VSP_018293"
FT CONFLICT 138
FT /note="S -> T (in Ref. 1; AAC83616)"
FT /evidence="ECO:0000305"
FT CONFLICT 152
FT /note="C -> G (in Ref. 1; AAC83616)"
FT /evidence="ECO:0000305"
FT CONFLICT 171..172
FT /note="AN -> H (in Ref. 1; AAC83616)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 235 AA; 27237 MW; 35DB85B37C7CFC66 CRC64;
MKLVQEEYRK GPWTEQEDIL LVNFVHLFGD RRWDFVAKVS GLNRTGKSCR LRWVNYLHPG
LKRGKMTPQE ERLVLELHAK WGNRWSKIAR KLPGRTDNEI KNYWRTHMRK KAQEKKRPMS
PTSSSSNCCS SSMTTTTSQD TGGSNGKMNQ ECEDGYYSMD DIWREIDQSG ANVIKPVKDN
YYSEQSCYLN FPPLASPTWE SSLESIWNMD ADESKMSSFA IDQFPLSFEH GSGRL
