MYB5_ARATH
ID MYB5_ARATH Reviewed; 249 AA.
AC Q38850;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Transcription repressor MYB5;
DE AltName: Full=AtM2;
DE AltName: Full=Myb-related protein 5;
DE Short=AtMYB5;
GN Name=MYB5; Synonyms=M2; OrderedLocusNames=At3g13540; ORFNames=MRP15.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Landsberg erecta;
RX PubMed=8635574; DOI=10.1016/0014-5793(95)01461-6;
RA Li S.F., Santini J.M., Nicolaou O., Parish R.W.;
RT "A novel myb-related gene from Arabidopsis thaliana.";
RL FEBS Lett. 379:117-121(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L.-J., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-157.
RX PubMed=8980549; DOI=10.1007/bf00020495;
RA Quaedvlieg N., Dockx J., Keultjes G., Kock P., Wilmering J., Weisbeek P.,
RA Smeekens S.;
RT "Identification of a light-regulated MYB gene from an Arabidopsis
RT transcription factor gene collection.";
RL Plant Mol. Biol. 32:987-993(1996).
RN [6]
RP TISSUE SPECIFICITY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [7]
RP GENE FAMILY.
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
RN [8]
RP FUNCTION, AND INTERACTION WITH BHLH002; BHLH012 AND BHLH042.
RX PubMed=15361138; DOI=10.1111/j.1365-313x.2004.02183.x;
RA Zimmermann I.M., Heim M.A., Weisshaar B., Uhrig J.F.;
RT "Comprehensive identification of Arabidopsis thaliana MYB transcription
RT factors interacting with R/B-like BHLH proteins.";
RL Plant J. 40:22-34(2004).
CC -!- FUNCTION: Transcription activator, when associated with
CC BHLH002/EGL3/MYC146, BHLH012/MYC1 or BHLH042/TT8.
CC {ECO:0000269|PubMed:15361138}.
CC -!- SUBUNIT: Interacts with BHLH002/EGL3/MYC146, BHLH012/MYC1 and
CC BHLH042/TT8. {ECO:0000269|PubMed:15361138}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Siliques. {ECO:0000269|PubMed:9839469}.
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DR EMBL; U26935; AAC49311.1; -; Genomic_DNA.
DR EMBL; AY519587; AAS10057.1; -; mRNA.
DR EMBL; AP000603; BAB01761.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75369.1; -; Genomic_DNA.
DR EMBL; X90380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; S68688; S68688.
DR RefSeq; NP_187963.1; NM_112200.3.
DR AlphaFoldDB; Q38850; -.
DR SMR; Q38850; -.
DR BioGRID; 5890; 10.
DR IntAct; Q38850; 10.
DR STRING; 3702.AT3G13540.1; -.
DR PaxDb; Q38850; -.
DR PRIDE; Q38850; -.
DR ProteomicsDB; 251376; -.
DR EnsemblPlants; AT3G13540.1; AT3G13540.1; AT3G13540.
DR GeneID; 820556; -.
DR Gramene; AT3G13540.1; AT3G13540.1; AT3G13540.
DR KEGG; ath:AT3G13540; -.
DR Araport; AT3G13540; -.
DR TAIR; locus:2092820; AT3G13540.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_6_4_1; -.
DR InParanoid; Q38850; -.
DR OMA; CCTKMGM; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q38850; -.
DR PRO; PR:Q38850; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q38850; differential.
DR Genevisible; Q38850; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0048354; P:mucilage biosynthetic process involved in seed coat development; IMP:TAIR.
DR GO; GO:0010468; P:regulation of gene expression; IEP:TAIR.
DR GO; GO:0010214; P:seed coat development; IMP:TAIR.
DR GO; GO:0010090; P:trichome morphogenesis; IMP:TAIR.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..249
FT /note="Transcription repressor MYB5"
FT /id="PRO_0000358831"
FT DOMAIN 20..72
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 73..127
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 48..72
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 100..123
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 133..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 44..46
FT /note="GEG -> VEV (in Ref. 5; X90380)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 249 AA; 27793 MW; AFDEFA57222B2424 CRC64;
MMSCGGKKPV SKKTTPCCTK MGMKRGPWTV EEDEILVSFI KKEGEGRWRS LPKRAGLLRC
GKSCRLRWMN YLRPSVKRGG ITSDEEDLIL RLHRLLGNRW SLIAGRIPGR TDNEIKNYWN
THLRKKLLRQ GIDPQTHKPL DANNIHKPEE EVSGGQKYPL EPISSSHTDD TTVNGGDGDS
KNSINVFGGE HGYEDFGFCY DDKFSSFLNS LINDVGDPFG NIIPISQPLQ MDDCKDGIVG
ASSSSLGHD
