MYB62_ARATH
ID MYB62_ARATH Reviewed; 286 AA.
AC Q9C9G7; Q9ZTD3;
DT 15-FEB-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Transcription factor MYB62 {ECO:0000303|PubMed:9839469};
DE AltName: Full=Myb-related protein 62 {ECO:0000303|PubMed:9839469};
DE Short=AtMYB62 {ECO:0000303|PubMed:9839469};
GN Name=MYB62 {ECO:0000303|PubMed:9839469};
GN OrderedLocusNames=At1g68320 {ECO:0000312|Araport:AT1G68320};
GN ORFNames=T22E19.5 {ECO:0000312|EMBL:AAG52612.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: A genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 83-286, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [5]
RP GENE FAMILY.
RX PubMed=9628022; DOI=10.1046/j.1365-313x.1998.00113.x;
RA Romero I., Fuertes A., Benito M.J., Malpica J.M., Leyva A., Paz-Ares J.;
RT "More than 80 R2R3-MYB regulatory genes in the genome of Arabidopsis
RT thaliana.";
RL Plant J. 14:273-284(1998).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [7]
RP INDUCTION BY SALICYLIC ACID, AND GENE FAMILY.
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
RN [8]
RP FUNCTION, INDUCTION BY PHOSPHATE DEFICIENCY, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=19529828; DOI=10.1093/mp/ssn081;
RA Devaiah B.N., Madhuvanthi R., Karthikeyan A.S., Raghothama K.G.;
RT "Phosphate starvation responses and gibberellic acid biosynthesis are
RT regulated by the MYB62 transcription factor in Arabidopsis.";
RL Mol. Plant 2:43-58(2009).
CC -!- FUNCTION: Transcription repressor of phosphate (Pi) starvation-induced
CC genes. Regulates negatively Pi starvation responses via the repression
CC of gibberellic acid (GA) biosynthesis and signaling. Modulates root
CC architecture, phosphatase activity, and Pi uptake and accumulation.
CC {ECO:0000269|PubMed:19529828}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:19529828}.
CC -!- TISSUE SPECIFICITY: Expressed in leaves and flowers.
CC {ECO:0000269|PubMed:19529828}.
CC -!- INDUCTION: Slightly induced by salicylic acid (PubMed:16463103).
CC Induced reversibly in response to phosphate (Pi) deficiency but
CC repressed in the presence of Pi, specifically in the leaves.
CC Availability of Pi increases with decreased levels (PubMed:19529828).
CC {ECO:0000269|PubMed:16463103, ECO:0000269|PubMed:19529828}.
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DR EMBL; AY519568; AAS10038.1; -; mRNA.
DR EMBL; AC016447; AAG52612.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34781.1; -; Genomic_DNA.
DR EMBL; AF062897; AAC83619.1; -; mRNA.
DR PIR; H96706; H96706.
DR PIR; T51669; T51669.
DR RefSeq; NP_176999.1; NM_105503.3.
DR AlphaFoldDB; Q9C9G7; -.
DR SMR; Q9C9G7; -.
DR IntAct; Q9C9G7; 16.
DR STRING; 3702.AT1G68320.1; -.
DR PaxDb; Q9C9G7; -.
DR PRIDE; Q9C9G7; -.
DR EnsemblPlants; AT1G68320.1; AT1G68320.1; AT1G68320.
DR GeneID; 843161; -.
DR Gramene; AT1G68320.1; AT1G68320.1; AT1G68320.
DR KEGG; ath:AT1G68320; -.
DR Araport; AT1G68320; -.
DR TAIR; locus:2199357; AT1G68320.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_8_2_1; -.
DR InParanoid; Q9C9G7; -.
DR OMA; DISMECH; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q9C9G7; -.
DR PRO; PR:Q9C9G7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C9G7; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0016036; P:cellular response to phosphate starvation; IEP:TAIR.
DR GO; GO:0009740; P:gibberellic acid mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0009686; P:gibberellin biosynthetic process; IMP:TAIR.
DR GO; GO:0010373; P:negative regulation of gibberellin biosynthetic process; IMP:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0055062; P:phosphate ion homeostasis; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0010015; P:root morphogenesis; IMP:UniProtKB.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR044676; EOBI/EOBII-like_plant.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR45675; PTHR45675; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Gibberellin signaling pathway; Nucleus; Reference proteome;
KW Repeat; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..286
FT /note="Transcription factor MYB62"
FT /id="PRO_0000438966"
FT DOMAIN 16..68
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 69..123
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 44..68
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 96..119
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
SQ SEQUENCE 286 AA; 33239 MW; C6765A6B744CC717 CRC64;
MENSMKKKKS FKESEDEELR RGPWTLEEDT LLTNYILHNG EGRWNHVAKC AGLKRTGKSC
RLRWLNYLKP DIRRGNLTPQ EQLLILELHS KWGNRWSKIA QYLPGRTDNE IKNYWRTRVQ
KQARQLNIES NSDKFFDAVR SFWVPRLIEK MEQNSSTTTT YCCPQNNNNN SLLLPSQSHD
SLSMQKDIDY SGFSNIDGSS STSTCMSHLT TVPHFMDQSN TNIIDGSMCF HEGNVQEFGG
YVPGMEDYMV NSDISMECHV ADGYSAYEDV TQDPMWNVDD IWQFRE
