MYB63_ARATH
ID MYB63_ARATH Reviewed; 294 AA.
AC Q6R0A6; O64534; Q9SBF8;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Transcription factor MYB63 {ECO:0000303|PubMed:9839469};
DE AltName: Full=Myb-related protein 63 {ECO:0000303|PubMed:9839469};
DE Short=AtMYB63 {ECO:0000303|PubMed:9839469};
GN Name=MYB63 {ECO:0000303|PubMed:9839469};
GN OrderedLocusNames=At1g79180 {ECO:0000312|Araport:AT1G79180};
GN ORFNames=YUP8H12R.21 {ECO:0000312|EMBL:AAC17044.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: A genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA de los Reyes C., Quan R., Chen H., Bautista V., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 70-294, TISSUE SPECIFICITY, INDUCTION BY UV,
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [8]
RP INDUCTION BY SALICYLIC ACID AND JASMONIC ACID.
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
RN [9]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP INDUCTION BY SND1 CLOSE HOMOLOGS, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=19122102; DOI=10.1105/tpc.108.063321;
RA Zhou J., Lee C., Zhong R., Ye Z.-H.;
RT "MYB58 and MYB63 are transcriptional activators of the lignin biosynthetic
RT pathway during secondary cell wall formation in Arabidopsis.";
RL Plant Cell 21:248-266(2009).
RN [10]
RP REVIEW.
RX PubMed=19838072; DOI=10.4161/psb.4.11.9875;
RA Zhong R., Ye Z.H.;
RT "Transcriptional regulation of lignin biosynthesis.";
RL Plant Signal. Behav. 4:1028-1034(2009).
RN [11]
RP INDUCTION BY MYB46 AND MYB83.
RX PubMed=22197883; DOI=10.1093/pcp/pcr185;
RA Zhong R., Ye Z.H.;
RT "MYB46 and MYB83 bind to the SMRE sites and directly activate a suite of
RT transcription factors and secondary wall biosynthetic genes.";
RL Plant Cell Physiol. 53:368-380(2012).
CC -!- FUNCTION: Transcriptional activator that binds DNA to the AC cis-
CC elements 5'-ACCTACC-3', 5'-ACCAACC-3' and 5'-ACCTAAC-3' of promoters
CC and specifically activates lignin biosynthetic genes during secondary
CC wall formation mediated by SND1. {ECO:0000269|PubMed:19122102}.
CC -!- INTERACTION:
CC Q6R0A6; F4I171: MED15A; NbExp=3; IntAct=EBI-15198077, EBI-21254477;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:19122102}.
CC -!- TISSUE SPECIFICITY: Expressed at low levels in stems, roots and
CC siliques (PubMed:9839469). Specifically expressed in fibers and vessels
CC undergoing secondary wall thickening, especially in inflorescence stems
CC (PubMed:19122102). {ECO:0000269|PubMed:19122102,
CC ECO:0000269|PubMed:9839469}.
CC -!- DEVELOPMENTAL STAGE: In nonelongating internodes, highly expressed in
CC interfascicular fibers and xylem cells but not in parenchymatous pith
CC cells. In elongating internodes, predominantly expressed in
CC interfascicular fibers. Accumulates in the developing secondary xylem
CC of roots. {ECO:0000269|PubMed:19122102}.
CC -!- INDUCTION: Slightly induced by UV light (PubMed:9839469). Triggered by
CC salicylic acid and jasmonic acid (PubMed:16463103). Regulated by the
CC SND1 close homologs NST1, NST2, VND6, and VND7 and their downstream
CC targets MYB46 and MYB83 (PubMed:19122102, PubMed:22197883).
CC {ECO:0000269|PubMed:16463103, ECO:0000269|PubMed:19122102,
CC ECO:0000269|PubMed:22197883, ECO:0000269|PubMed:9839469}.
CC -!- DISRUPTION PHENOTYPE: Reduction in secondary wall thickening and lignin
CC content. {ECO:0000269|PubMed:19122102}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC17044.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY519572; AAS10042.1; -; mRNA.
DR EMBL; AC002986; AAC17044.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE36212.1; -; Genomic_DNA.
DR EMBL; AK175344; BAD43107.1; -; mRNA.
DR EMBL; BT033125; ACF22901.1; -; mRNA.
DR EMBL; AF062898; AAC83620.1; -; mRNA.
DR PIR; T01038; T01038.
DR PIR; T51670; T51670.
DR RefSeq; NP_001321204.1; NM_001334873.1.
DR RefSeq; NP_178039.1; NM_106569.4.
DR AlphaFoldDB; Q6R0A6; -.
DR SMR; Q6R0A6; -.
DR IntAct; Q6R0A6; 7.
DR STRING; 3702.AT1G79180.1; -.
DR PaxDb; Q6R0A6; -.
DR PRIDE; Q6R0A6; -.
DR EnsemblPlants; AT1G79180.1; AT1G79180.1; AT1G79180.
DR GeneID; 844259; -.
DR Gramene; AT1G79180.1; AT1G79180.1; AT1G79180.
DR KEGG; ath:AT1G79180; -.
DR Araport; AT1G79180; -.
DR TAIR; locus:2207330; AT1G79180.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_6_2_1; -.
DR InParanoid; Q6R0A6; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q6R0A6; -.
DR PRO; PR:Q6R0A6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q6R0A6; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0009809; P:lignin biosynthetic process; IMP:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:TAIR.
DR GO; GO:2000652; P:regulation of secondary cell wall biogenesis; IMP:TAIR.
DR GO; GO:0009411; P:response to UV; IEP:UniProtKB.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Lignin biosynthesis; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation.
FT CHAIN 1..294
FT /note="Transcription factor MYB63"
FT /id="PRO_0000438720"
FT DOMAIN 11..63
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 64..118
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 39..63
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 91..114
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 117..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..157
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 174
FT /note="Q -> QDD (in Ref. 6; AAC83620)"
FT /evidence="ECO:0000305"
FT CONFLICT 187..189
FT /note="IEE -> TQ (in Ref. 6; AAC83620)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 294 AA; 33780 MW; 14A44CA901B387E4 CRC64;
MGKGRAPCCD KTKVKRGPWS PEEDIKLISF IQKFGHENWR SLPKQSGLLR CGKSCRLRWI
NYLRPDLKRG NFTSEEEETI IKLHHNYGNK WSKIASQLPG RTDNEIKNVW HTHLKKRLAQ
SSGTADEPAS PCSSDSVSRG KDDKSSHVED SLNRETNHRN ELSTSMSSGG SNQQDDPKID
ELRFEYIEEA YSEFNDIIIQ EVDKPDLLEI PFDSDPDIWS FLDTSNSFQQ STANENSSGS
RATTEEESDE DEVKKWFKHL ESELGLEEDD NQQQYKEEES SSSSLLKNYE LMIH
