MYB72_ARATH
ID MYB72_ARATH Reviewed; 296 AA.
AC Q9SGU3; Q9ZTC9;
DT 22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Transcription factor MYB72 {ECO:0000303|PubMed:9839469};
DE AltName: Full=Myb-related protein 72 {ECO:0000303|PubMed:9839469};
DE Short=AtMYB72 {ECO:0000303|PubMed:9839469};
GN Name=MYB72 {ECO:0000303|PubMed:9839469};
GN OrderedLocusNames=At1g56160 {ECO:0000312|Araport:AT1G56160};
GN ORFNames=F14G9.22 {ECO:0000312|EMBL:AAG50903.1},
GN T6H22.4 {ECO:0000312|EMBL:AAF02833.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 74-296, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [5]
RP INDUCTION BY POTASSIUM STARVATION.
RX PubMed=15489280; DOI=10.1104/pp.104.046672;
RA Hampton C.R., Bowen H.C., Broadley M.R., Hammond J.P., Mead A., Payne K.A.,
RA Pritchard J., White P.J.;
RT "Cesium toxicity in Arabidopsis.";
RL Plant Physiol. 136:3824-3837(2004).
RN [6]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION BY ZINC AND CADMIUM.
RC STRAIN=cv. Columbia;
RX PubMed=18088336; DOI=10.1111/j.1365-3040.2007.01764.x;
RA van de Mortel J.E., Schat H., Moerland P.D., Ver Loren van Themaat E.,
RA van der Ent S., Blankestijn H., Ghandilyan A., Tsiatsiani S., Aarts M.G.M.;
RT "Expression differences for genes involved in lignin, glutathione and
RT sulphate metabolism in response to cadmium in Arabidopsis thaliana and the
RT related Zn/Cd-hyperaccumulator Thlaspi caerulescens.";
RL Plant Cell Environ. 31:301-324(2008).
RN [7]
RP FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY PSEUDOMONAS FLUORESCENS
RP WCS417R, AND INTERACTION WITH EIL3.
RC STRAIN=cv. Columbia;
RX PubMed=18218967; DOI=10.1104/pp.107.113829;
RA Van der Ent S., Verhagen B.W.M., Van Doorn R., Bakker D., Verlaan M.G.,
RA Pel M.J.C., Joosten R.G., Proveniers M.C.G., Van Loon L.C., Ton J.,
RA Pieterse C.M.J.;
RT "MYB72 is required in early signaling steps of rhizobacteria-induced
RT systemic resistance in Arabidopsis.";
RL Plant Physiol. 146:1293-1304(2008).
RN [8]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=19121118; DOI=10.1111/j.1438-8677.2008.00162.x;
RA Segarra G., Van der Ent S., Trillas I., Pieterse C.M.J.;
RT "MYB72, a node of convergence in induced systemic resistance triggered by a
RT fungal and a bacterial beneficial microbe.";
RL Plant Biol. 11:90-96(2009).
RN [9]
RP FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY IRON STARVATION, AND
RP SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=24278034; DOI=10.1371/journal.pgen.1003953;
RA Palmer C.M., Hindt M.N., Schmidt H., Clemens S., Guerinot M.L.;
RT "MYB10 and MYB72 are required for growth under iron-limiting conditions.";
RL PLoS Genet. 9:E1003953-E1003953(2013).
RN [10]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=25138267; DOI=10.1111/nph.12980;
RA Zamioudis C., Hanson J., Pieterse C.M.J.;
RT "beta-Glucosidase BGLU42 is a MYB72-dependent key regulator of
RT rhizobacteria-induced systemic resistance and modulates iron deficiency
RT responses in Arabidopsis roots.";
RL New Phytol. 204:368-379(2014).
CC -!- FUNCTION: Involved in metal ions homeostasis, including iron ions (Fe)
CC acquisition, via the regulation of NAS4 and NAS2 genes expression.
CC Necessary for plant survival in alkaline soil where iron availability
CC is greatly restricted (PubMed:18088336, PubMed:24278034). Involved in
CC the up-regulation of several biosynthesis genes of secondary
CC metabolites involved in iron uptake under conditions of iron deficiency
CC (PubMed:25138267). Triggers tolerance to nickel (Ni) and zinc (Zn) ions
CC (PubMed:24278034). Required in the roots during early signaling steps
CC of rhizobacteria-mediated (e.g. P.fluorescens WCS417r) and beneficial
CC fungi-mediated (e.g. T.asperellum T34) broad-spectrum induced systemic
CC resistance (ISR) against several pathogens (e.g. P.syringae pv tomato,
CC H.parasitica, P.cucumerina, A.brassicicola and B.cinerea) and implying
CC enhanced callose deposition (PubMed:18218967, PubMed:19121118).
CC Required for the induction of some genes (e.g. BGLU42) upon
CC rhizobacteria-mediated ISR (PubMed:25138267).
CC {ECO:0000269|PubMed:18088336, ECO:0000269|PubMed:18218967,
CC ECO:0000269|PubMed:19121118, ECO:0000269|PubMed:24278034,
CC ECO:0000269|PubMed:25138267}.
CC -!- SUBUNIT: Interacts with EIL3. {ECO:0000269|PubMed:18218967}.
CC -!- INTERACTION:
CC Q9SGU3; Q9M1R4: IAA30; NbExp=3; IntAct=EBI-1789562, EBI-3946710;
CC Q9SGU3; Q9SZI2: NAP1;1; NbExp=3; IntAct=EBI-1789562, EBI-4424361;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:24278034}.
CC -!- INDUCTION: Accumulates strongly in the root stele when exposed to iron
CC (Fe)-deficient conditions (PubMed:24278034). Accumulates upon potassium
CC ion (K) depletion (PubMed:15489280). Induced in roots by zinc (Zn) and
CC cadmium (Cd) ions (PubMed:18088336). Specifically activated in the
CC roots upon colonization by nonpathogenic P.fluorescens WCS417r
CC (PubMed:18218967). {ECO:0000269|PubMed:15489280,
CC ECO:0000269|PubMed:18088336, ECO:0000269|PubMed:18218967,
CC ECO:0000269|PubMed:24278034}.
CC -!- DISRUPTION PHENOTYPE: Shorter roots due to increased sensitivity to
CC excess zinc ions (Zn) and iron ions (Fe) deficiency, respectively
CC (PubMed:18088336). Reduced production of root-derived phenolics upon
CC iron ions (Fe) depletion (PubMed:25138267). Plants lacking myb10 and
CC myb72 fail to induce transcript accumulation of the nicotianamine
CC synthase genes NAS4 and NAS2 in iron ions (Fe) deficiency, and exhibits
CC nickel (Ni) and zinc (Zn) sensitivity (PubMed:24278034). Impaired
CC P.fluorescens WCS417r- and T.asperellum T34- mediated broad-spectrum
CC induced systemic resistance (ISR) against the pathogens P.syringae pv
CC tomato, H.parasitica, A.brassicicola, P.cucumerina and B.cinerea and
CC characterized by blocked priming of enhanced callose deposition
CC (PubMed:18218967, PubMed:19121118). Misregulation of several genes
CC (e.g. BGLU42) triggered by P.fluorescens WCS417r upon ISR
CC (PubMed:25138267). {ECO:0000269|PubMed:18088336,
CC ECO:0000269|PubMed:18218967, ECO:0000269|PubMed:19121118,
CC ECO:0000269|PubMed:24278034, ECO:0000269|PubMed:25138267}.
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DR EMBL; AC009894; AAF02833.1; -; Genomic_DNA.
DR EMBL; AC069159; AAG50903.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33352.1; -; Genomic_DNA.
DR EMBL; AF062905; AAC83627.1; -; mRNA.
DR PIR; A96603; A96603.
DR PIR; T51677; T51677.
DR RefSeq; NP_176012.1; NM_104495.1.
DR AlphaFoldDB; Q9SGU3; -.
DR SMR; Q9SGU3; -.
DR IntAct; Q9SGU3; 4.
DR STRING; 3702.AT1G56160.1; -.
DR PaxDb; Q9SGU3; -.
DR PRIDE; Q9SGU3; -.
DR EnsemblPlants; AT1G56160.1; AT1G56160.1; AT1G56160.
DR GeneID; 842069; -.
DR Gramene; AT1G56160.1; AT1G56160.1; AT1G56160.
DR KEGG; ath:AT1G56160; -.
DR Araport; AT1G56160; -.
DR TAIR; locus:2011786; AT1G56160.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_25_3_1; -.
DR InParanoid; Q9SGU3; -.
DR OMA; NNEYDEW; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q9SGU3; -.
DR PRO; PR:Q9SGU3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SGU3; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0051365; P:cellular response to potassium ion starvation; IEP:UniProtKB.
DR GO; GO:0009866; P:induced systemic resistance, ethylene mediated signaling pathway; IMP:UniProtKB.
DR GO; GO:0055065; P:metal ion homeostasis; IMP:UniProtKB.
DR GO; GO:0010468; P:regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0046686; P:response to cadmium ion; IEP:UniProtKB.
DR GO; GO:1990641; P:response to iron ion starvation; IMP:UniProtKB.
DR GO; GO:0002237; P:response to molecule of bacterial origin; IMP:UniProtKB.
DR GO; GO:0010043; P:response to zinc ion; IDA:UniProtKB.
DR GO; GO:0019748; P:secondary metabolic process; IMP:UniProtKB.
DR GO; GO:1990532; P:stress response to nickel ion; IMP:UniProtKB.
DR GO; GO:1990359; P:stress response to zinc ion; IMP:UniProtKB.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Plant defense; Reference proteome; Repeat;
KW Transcription; Transcription regulation.
FT CHAIN 1..296
FT /note="Transcription factor MYB72"
FT /id="PRO_0000442349"
FT DOMAIN 11..63
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 64..118
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 39..63
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 91..114
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 118..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 202
FT /note="F -> S (in Ref. 3; AAC83627)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 296 AA; 34107 MW; C4C0A1742085F671 CRC64;
MGKGRAPCCD KNKVKRGPWS PQEDLTLITF IQKHGHQNWR SLPKLAGLLR CGKSCRLRWI
NYLRPDVKRG NFSKKEEDAI IHYHQTLGNK WSKIASFLPG RTDNEIKNVW NTHLKKRLTP
SSSSSSLSST HDQSTKADHD KNCDGAQEEI HSGLNESQNS ATSSHHQGEC MHTKPELHEV
NGLNEIQFLL DHDDFDDITS EFLQDNDILF PLDSLLHNHQ THISTQEMTR EVTKSQSFDH
PQPDIPCGFE DTNEESDLRR QLVESTTPNN EYDEWFNFID NQTYFDDFNF VGEVCL