MYB74_ARATH
ID MYB74_ARATH Reviewed; 324 AA.
AC Q9M0Y5; Q6R077; Q9ZTC8;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Transcription factor MYB74 {ECO:0000305};
DE AltName: Full=Myb-related protein 74 {ECO:0000305};
DE Short=AtMYB74 {ECO:0000303|PubMed:26139822};
GN Name=MYB74 {ECO:0000303|PubMed:9839469};
GN OrderedLocusNames=At4g05100 {ECO:0000312|Araport:AT4G05100};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 66-324.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION BY SALT
RP STRESS.
RX PubMed=26139822; DOI=10.1093/jxb/erv312;
RA Xu R., Wang Y., Zheng H., Lu W., Wu C., Huang J., Yan K., Yang G.,
RA Zheng C.;
RT "Salt-induced transcription factor MYB74 is regulated by the RNA-directed
RT DNA methylation pathway in Arabidopsis.";
RL J. Exp. Bot. 66:5997-6008(2015).
CC -!- FUNCTION: Probable transcription factor that may function in salt
CC stress response. {ECO:0000305|PubMed:26139822}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:26139822}.
CC -!- TISSUE SPECIFICITY: Highly expressed in flowers and at lower levels in
CC rosette leaves and cauline leaves. Expressed at low levels in roots,
CC stems and siliques. {ECO:0000269|PubMed:26139822}.
CC -!- INDUCTION: Induced by salt stress. {ECO:0000269|PubMed:26139822}.
CC -!- MISCELLANEOUS: Seeds over-expressing MYB74 display hypersensitivity to
CC salt stress during seed germination. {ECO:0000269|PubMed:26139822}.
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DR EMBL; AY519603; AAS10073.1; -; mRNA.
DR EMBL; AL161502; CAB81052.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82479.1; -; Genomic_DNA.
DR EMBL; AF386932; AAK62377.1; -; mRNA.
DR EMBL; BT001182; AAN65069.1; -; mRNA.
DR EMBL; AF062907; AAC83629.1; -; mRNA.
DR PIR; B85064; B85064.
DR PIR; T51679; T51679.
DR RefSeq; NP_192419.1; NM_116749.3.
DR AlphaFoldDB; Q9M0Y5; -.
DR SMR; Q9M0Y5; -.
DR IntAct; Q9M0Y5; 1.
DR STRING; 3702.AT4G05100.1; -.
DR PaxDb; Q9M0Y5; -.
DR PRIDE; Q9M0Y5; -.
DR EnsemblPlants; AT4G05100.1; AT4G05100.1; AT4G05100.
DR GeneID; 825855; -.
DR Gramene; AT4G05100.1; AT4G05100.1; AT4G05100.
DR KEGG; ath:AT4G05100; -.
DR Araport; AT4G05100; -.
DR TAIR; locus:2115708; AT4G05100.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_15_2_1; -.
DR InParanoid; Q9M0Y5; -.
DR OMA; AHINDMD; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q9M0Y5; -.
DR PRO; PR:Q9M0Y5; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9M0Y5; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0009737; P:response to abscisic acid; IEP:TAIR.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Stress response;
KW Transcription; Transcription regulation.
FT CHAIN 1..324
FT /note="Transcription factor MYB74"
FT /id="PRO_0000439654"
FT DOMAIN 10..62
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 63..117
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 38..62
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 90..113
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT CONFLICT 84
FT /note="S -> G (in Ref. 5; AAC83629)"
FT /evidence="ECO:0000305"
FT CONFLICT 273
FT /note="L -> F (in Ref. 1; AAS10073)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 324 AA; 37397 MW; 0C6E44F86D73CA2C CRC64;
MGRSPCCEKK NGLKKGPWTP EEDQKLIDYI NIHGYGNWRT LPKNAGLQRC GKSCRLRWTN
YLRPDIKRGR FSFEEEETII QLHSIMGNKW SAIAARLPGR TDNEIKNYWN THIRKRLLKM
GIDPVTHTPR LDLLDISSIL SSSIYNSSHH HHHHHQQHMN MSRLMMSDGN HQPLVNPEIL
KLATSLFSNQ NHPNNTHENN TVNQTEVNQY QTGYNMPGNE ELQSWFPIMD QFTNFQDLMP
MKTTVQNSLS YDDDCSKSNF VLEPYYSDFA SVLTTPSSSP TPLNSSSSTY INSSTCSTED
EKESYYSDNI TNYSFDVNGF LQFQ
