MYB7_ARATH
ID MYB7_ARATH Reviewed; 269 AA.
AC Q42379; Q8VY75; Q9SAL8;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 176.
DE RecName: Full=Transcription factor MYB7 {ECO:0000305};
DE AltName: Full=Myb-related protein 7 {ECO:0000305};
DE Short=AtMYB7 {ECO:0000312|EMBL:CAB09243.1};
DE AltName: Full=Myb-related protein Y49 {ECO:0000305};
DE Short=AtY49 {ECO:0000303|PubMed:8980549};
GN Name=MYB7 {ECO:0000312|EMBL:CAB09243.1};
GN OrderedLocusNames=At2g16720 {ECO:0000312|Araport:AT2G16720};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Landsberg erecta;
RX PubMed=8580966; DOI=10.1046/j.1365-313x.1995.8060963.x;
RA Li S.F., Parish R.W.;
RT "Isolation of two novel myb-like genes from Arabidopsis and studies on the
RT DNA-binding properties of their products.";
RL Plant J. 8:963-972(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8980549; DOI=10.1007/bf00020495;
RA Quaedvlieg N., Dockx J., Keultjes G., Kock P., Wilmering J., Weisbeek P.,
RA Smeekens S.;
RT "Identification of a light-regulated MYB gene from an Arabidopsis
RT transcription factor gene collection.";
RL Plant Mol. Biol. 32:987-993(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 55-99.
RC STRAIN=cv. Landsberg erecta;
RA Romero I., Fuertes A., Benito M.J., Malpica J., Leyva A., Paz-Ares J.;
RT "One hundred R2R3-MYB genes in the genome of Arabidopsis thaliana.";
RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 96-269 AND 216-269.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [8]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=24319076; DOI=10.1093/pcp/pct187;
RA Fornale S., Lopez E., Salazar-Henao J.E., Fernandez-Nohales P., Rigau J.,
RA Caparros-Ruiz D.;
RT "AtMYB7, a new player in the regulation of UV-sunscreens in Arabidopsis
RT thaliana.";
RL Plant Cell Physiol. 55:507-516(2014).
RN [9]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=25053018; DOI=10.1111/pce.12415;
RA Kim J.H., Hyun W.Y., Nguyen H.N., Jeong C.Y., Xiong L., Hong S.W., Lee H.;
RT "AtMyb7, a subgroup 4 R2R3 Myb, negatively regulates ABA-induced inhibition
RT of seed germination by blocking the expression of the bZIP transcription
RT factor ABI5.";
RL Plant Cell Environ. 38:559-571(2015).
RN [10]
RP INTERACTION WITH SAD2, SUBCELLULAR LOCATION, AND MUTAGENESIS OF ASP-252.
RX PubMed=26332741; DOI=10.1111/tpj.13008;
RA Zhou M., Sun Z., Wang C., Zhang X., Tang Y., Zhu X., Shao J., Wu Y.;
RT "Changing a conserved amino acid in R2R3-MYB transcription repressors
RT results in cytoplasmic accumulation and abolishes their repressive activity
RT in Arabidopsis.";
RL Plant J. 84:395-403(2015).
CC -!- FUNCTION: Transcription factor involved in the negative regulation of
CC flavonol biosynthesis. Represses the early phenylpropanoid genes,
CC phenylalanine ammonia-lyase (PAL), cinnamate 4-hydroxylase (C4H) and 4-
CC coumarate-CoA ligase (4CL), as well as the flavonoid-specific genes,
CC flavonoid 3'-hydroxylase (F3'H) and dihydroflavonol 4-reductase (DFR)
CC (PubMed:24319076). Plays a role in seed germination inhibition.
CC Negatively regulates the expression of the abscisic acid (ABA)
CC signaling transcription factor ABI5 in seeds (PubMed:25053018).
CC {ECO:0000269|PubMed:24319076, ECO:0000269|PubMed:25053018}.
CC -!- SUBUNIT: Interacts with SAD2. {ECO:0000269|PubMed:26332741}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:25053018, ECO:0000269|PubMed:26332741}.
CC -!- TISSUE SPECIFICITY: Expressed in anthers (PubMed:24319076,
CC PubMed:25053018). Expressed in pollen grains and mature seeds
CC (PubMed:25053018). Expressed in roots and vasculature of leaves
CC (PubMed:24319076). {ECO:0000269|PubMed:24319076,
CC ECO:0000269|PubMed:25053018}.
CC -!- INDUCTION: Induced by abscisic acid (ABA) and osmotic stress
CC (PubMed:25053018). Induced by salt stress (PubMed:24319076,
CC PubMed:25053018). {ECO:0000269|PubMed:24319076,
CC ECO:0000269|PubMed:25053018}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions. Increased levels of flavonols (PubMed:24319076). Decreased
CC levels of anthocyanins (PubMed:24319076, PubMed:25053018).
CC {ECO:0000269|PubMed:24319076, ECO:0000269|PubMed:25053018}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL62379.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U26937; AAA98762.1; -; mRNA.
DR EMBL; X90385; CAA62033.1; -; Genomic_DNA.
DR EMBL; AY519573; AAS10043.1; -; mRNA.
DR EMBL; AC005825; AAD24605.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06531.1; -; Genomic_DNA.
DR EMBL; Z95811; CAB09243.1; -; mRNA.
DR EMBL; AY072387; AAL62379.1; ALT_INIT; mRNA.
DR EMBL; BT000161; AAN15480.1; -; mRNA.
DR PIR; S58292; S58292.
DR RefSeq; NP_179263.1; NM_127224.6.
DR AlphaFoldDB; Q42379; -.
DR SMR; Q42379; -.
DR STRING; 3702.AT2G16720.1; -.
DR PaxDb; Q42379; -.
DR PRIDE; Q42379; -.
DR ProteomicsDB; 251331; -.
DR EnsemblPlants; AT2G16720.1; AT2G16720.1; AT2G16720.
DR GeneID; 816173; -.
DR Gramene; AT2G16720.1; AT2G16720.1; AT2G16720.
DR KEGG; ath:AT2G16720; -.
DR Araport; AT2G16720; -.
DR TAIR; locus:2059883; AT2G16720.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_23_2_1; -.
DR InParanoid; Q42379; -.
DR OMA; MENGMEC; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q42379; -.
DR PRO; PR:Q42379; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q42379; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:1900384; P:regulation of flavonol biosynthetic process; IMP:TAIR.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..269
FT /note="Transcription factor MYB7"
FT /id="PRO_0000439651"
FT DOMAIN 9..61
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 62..116
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 37..61
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 89..112
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT MUTAGEN 252
FT /note="D->N: Loss of nuclear localization; cytoplasmic
FT localization; abolishes interaction with SAD2."
FT /evidence="ECO:0000269|PubMed:26332741"
SQ SEQUENCE 269 AA; 31009 MW; 7A6C5D7C3CA0135C CRC64;
MGRSPCCEKE HMNKGAWTKE EDERLVSYIK SHGEGCWRSL PRAAGLLRCG KSCRLRWINY
LRPDLKRGNF THDEDELIIK LHSLLGNKWS LIAARLPGRT DNEIKNYWNT HIKRKLLSKG
IDPATHRGIN EAKISDLKKT KDQIVKDVSF VTKFEETDKS GDQKQNKYIR NGLVCKEERV
VVEEKIGPDL NLELRISPPW QNQREISTCT ASRFYMENDM ECSSETVKCQ TENSSSISYS
SIDISSSNVG YDFLGLKTRI LDFRSLEMK
