MYB90_ARATH
ID MYB90_ARATH Reviewed; 249 AA.
AC Q9ZTC3;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Transcription factor MYB90;
DE AltName: Full=Myb-related protein 90;
DE Short=AtMYB90;
DE AltName: Full=Production of anthocyanin pigment 2 protein;
GN Name=MYB90; Synonyms=PAP2; OrderedLocusNames=At1g66390; ORFNames=T27F4.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION BY SUCROSE;
RP NITROGEN DEFICIENCY; ETHYLENE; UV LIGHT AND DROUGHT.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=cv. Columbia;
RX PubMed=11148285; DOI=10.2307/3871236;
RA Borevitz J.O., Xia Y., Blount J., Dixon R.A., Lamb C.;
RT "Activation tagging identifies a conserved MYB regulator of phenylpropanoid
RT biosynthesis.";
RL Plant Cell 12:2383-2393(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [6]
RP INTERACTION WITH BHLH2.
RX PubMed=12917293; DOI=10.1242/dev.00681;
RA Zhang F., Gonzalez A., Zhao M., Payne C.T., Lloyd A.M.;
RT "A network of redundant bHLH proteins functions in all TTG1-dependent
RT pathways of Arabidopsis.";
RL Development 130:4859-4869(2003).
RN [7]
RP FUNCTION, AND INTERACTION WITH BHLH12; BHLH1; BHLH2 AND BHLH42.
RX PubMed=15361138; DOI=10.1111/j.1365-313x.2004.02183.x;
RA Zimmermann I.M., Heim M.A., Weisshaar B., Uhrig J.F.;
RT "Comprehensive identification of Arabidopsis thaliana MYB transcription
RT factors interacting with R/B-like BHLH proteins.";
RL Plant J. 40:22-34(2004).
RN [8]
RP GENE FAMILY.
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
RN [9]
RP INDUCTION BY NITROGEN DEFICIENCY.
RX PubMed=17053893; DOI=10.1007/s00425-006-0414-x;
RA Lea U.S., Slimestad R., Smedvig P., Lillo C.;
RT "Nitrogen deficiency enhances expression of specific MYB and bHLH
RT transcription factors and accumulation of end products in the flavonoid
RT pathway.";
RL Planta 225:1245-1253(2007).
CC -!- FUNCTION: Transcription activator, when associated with BHLH12/MYC1,
CC EGL3, or GL3. Promotes the synthesis of phenylpropanoid-derived
CC compounds such as anthocyanins. {ECO:0000269|PubMed:11148285,
CC ECO:0000269|PubMed:15361138}.
CC -!- SUBUNIT: Interacts with BHLH12/MYC1, BHLH1/GL3/MYC6, BHLH2/EGL3/MYC146,
CC and BHLH42/TT8. {ECO:0000269|PubMed:12917293,
CC ECO:0000269|PubMed:15361138}.
CC -!- INTERACTION:
CC Q9ZTC3; Q8W2F1: BHLH12; NbExp=2; IntAct=EBI-1545203, EBI-1546379;
CC Q9ZTC3; Q9CAD0: BHLH2; NbExp=3; IntAct=EBI-1545203, EBI-533398;
CC Q9ZTC3; Q9FN69: GL3; NbExp=2; IntAct=EBI-1545203, EBI-533348;
CC Q9ZTC3; Q9FT81: TT8; NbExp=2; IntAct=EBI-1545203, EBI-395790;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed only in leaves and siliques.
CC {ECO:0000269|PubMed:9839469}.
CC -!- INDUCTION: By sucrose, nitrogen deficiency, ethylene, UV light and
CC drought. {ECO:0000269|PubMed:17053893, ECO:0000269|PubMed:9839469}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF062915; AAC83637.1; -; mRNA.
DR EMBL; AF325124; AAG42002.1; -; mRNA.
DR EMBL; AC020665; AAG52164.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34503.1; -; Genomic_DNA.
DR PIR; T51687; T51687.
DR RefSeq; NP_176813.1; NM_105310.4.
DR AlphaFoldDB; Q9ZTC3; -.
DR SMR; Q9ZTC3; -.
DR BioGRID; 28178; 9.
DR IntAct; Q9ZTC3; 4.
DR STRING; 3702.AT1G66390.1; -.
DR PaxDb; Q9ZTC3; -.
DR PRIDE; Q9ZTC3; -.
DR EnsemblPlants; AT1G66390.1; AT1G66390.1; AT1G66390.
DR GeneID; 842957; -.
DR Gramene; AT1G66390.1; AT1G66390.1; AT1G66390.
DR KEGG; ath:AT1G66390; -.
DR Araport; AT1G66390; -.
DR TAIR; locus:2201532; AT1G66390.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_6_4_1; -.
DR InParanoid; Q9ZTC3; -.
DR OMA; CENSITC; -.
DR OrthoDB; 1072169at2759; -.
DR PhylomeDB; Q9ZTC3; -.
DR PRO; PR:Q9ZTC3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9ZTC3; baseline and differential.
DR Genevisible; Q9ZTC3; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Repeat;
KW Stress response; Transcription; Transcription regulation.
FT CHAIN 1..249
FT /note="Transcription factor MYB90"
FT /id="PRO_0000285271"
FT DOMAIN 5..57
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 58..112
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 33..57
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 85..108
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
SQ SEQUENCE 249 AA; 28100 MW; 309024FD4103700A CRC64;
MEGSSKGLRK GAWTAEEDSL LRLCIDKYGE GKWHQVPLRA GLNRCRKSCR LRWLNYLKPS
IKRGRLSNDE VDLLLRLHKL LGNRWSLIAG RLPGRTANDV KNYWNTHLSK KHESSCCKSK
MKKKNIISPP TTPVQKIGVF KPRPRSFSVN NGCSHLNGLP EVDLIPSCLG LKKNNVCENS
ITCNKDDEKD DFVNNLMNGD NMWLENLLGE NQEADAIVPE ATTAEHGATL AFDVEQLWSL
FDGETVELD
