MYB93_ARATH
ID MYB93_ARATH Reviewed; 365 AA.
AC Q9S9Z2;
DT 31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Transcription factor MYB93 {ECO:0000303|PubMed:11597504};
DE AltName: Full=Myb-related protein 93 {ECO:0000303|PubMed:11597504};
DE Short=AtMYB93 {ECO:0000303|PubMed:11597504};
GN Name=MYB93 {ECO:0000303|PubMed:11597504};
GN OrderedLocusNames=At1g34670 {ECO:0000312|Araport:AT1G34670};
GN ORFNames=F21H2.9 {ECO:0000312|EMBL:AAD46010.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: A genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [5]
RP FUNCTION, INTERACTION WITH FBX5, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE,
RP INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24902892; DOI=10.1111/nph.12879;
RA Gibbs D.J., Voss U., Harding S.A., Fannon J., Moody L.A., Yamada E.,
RA Swarup K., Nibau C., Bassel G.W., Choudhary A., Lavenus J., Bradshaw S.J.,
RA Stekel D.J., Bennett M.J., Coates J.C.;
RT "AtMYB93 is a novel negative regulator of lateral root development in
RT Arabidopsis.";
RL New Phytol. 203:1194-1207(2014).
RN [6]
RP DEVELOPMENTAL STAGE.
RX PubMed=25482809; DOI=10.4161/15592316.2014.970406;
RA Gibbs D.J., Coates J.C.;
RT "AtMYB93 is an endodermis-specific transcriptional regulator of lateral
RT root development in arabidopsis.";
RL Plant Signal. Behav. 9:E970406-E970406(2014).
CC -!- FUNCTION: Transcription factor that acts as negative regulator of
CC lateral root (LR) development. Required for normal auxin responses
CC during LR development. May be part of a negative feedback loop
CC stimulated specifically in the endodermis upon LR initiation to ensure
CC that LRs are formed only in the correct place.
CC {ECO:0000269|PubMed:24902892}.
CC -!- SUBUNIT: Interacts with FBX5. {ECO:0000269|PubMed:24902892}.
CC -!- INTERACTION:
CC Q9S9Z2; Q9FX36: MYB54; NbExp=3; IntAct=EBI-15202792, EBI-25511270;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:24902892}. Cytoplasm {ECO:0000269|PubMed:24902892}.
CC -!- DEVELOPMENTAL STAGE: Specifically and transiently expressed in root
CC endodermal cells overlying the early stages of lateral root primordia
CC formation. {ECO:0000269|PubMed:24902892, ECO:0000269|PubMed:25482809}.
CC -!- INDUCTION: Induced by abscisic acid (ABA), auxin and gravity in roots.
CC {ECO:0000269|PubMed:24902892}.
CC -!- DISRUPTION PHENOTYPE: High lateral root developmental progression and
CC enhanced lateral root density. {ECO:0000269|PubMed:24902892}.
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DR EMBL; AY519560; AAS10030.1; -; mRNA.
DR EMBL; AC007894; AAD46010.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31733.1; -; Genomic_DNA.
DR PIR; D86470; D86470.
DR RefSeq; NP_174726.1; NM_103190.2.
DR AlphaFoldDB; Q9S9Z2; -.
DR SMR; Q9S9Z2; -.
DR IntAct; Q9S9Z2; 3.
DR STRING; 3702.AT1G34670.1; -.
DR PaxDb; Q9S9Z2; -.
DR PRIDE; Q9S9Z2; -.
DR EnsemblPlants; AT1G34670.1; AT1G34670.1; AT1G34670.
DR GeneID; 840371; -.
DR Gramene; AT1G34670.1; AT1G34670.1; AT1G34670.
DR KEGG; ath:AT1G34670; -.
DR Araport; AT1G34670; -.
DR TAIR; locus:2023951; AT1G34670.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_15_4_1; -.
DR InParanoid; Q9S9Z2; -.
DR OMA; SCLNSEM; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q9S9Z2; -.
DR PRO; PR:Q9S9Z2; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9S9Z2; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0071365; P:cellular response to auxin stimulus; IEP:TAIR.
DR GO; GO:1901332; P:negative regulation of lateral root development; IMP:TAIR.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; DNA-binding; Growth regulation; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation.
FT CHAIN 1..365
FT /note="Transcription factor MYB93"
FT /id="PRO_0000442927"
FT DOMAIN 9..61
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 62..116
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 37..61
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 89..112
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
SQ SEQUENCE 365 AA; 41197 MW; 6D7ED85D263F0578 CRC64;
MGRSPCCDEN GLKKGPWTPE EDQKLIDYIH KHGHGSWRAL PKLADLNRCG KSCRLRWTNY
LRPDIKRGKF SAEEEQTILH LHSILGNKWS AIATHLQGRT DNEIKNFWNT HLKKKLIQMG
IDPVTHQPRT DLFASLPQLI ALANLKDLIE QTSQFSSMQG EAAQLANLQY LQRMFNSSAS
LTNNNGNNFS PSSILDIDQH HAMNLLNSMV SWNKDQNPAF DPVLELEAND QNQDLFPLGF
IIDQPTQPLQ QQKYHLNNSP SELPSQGDPL LDHVPFSLQT PLNSEDHFID NLVKHPTDHE
HEHDDNPSSW VLPSLIDNNP KTVTSSLPHN NPADASSSSS YGGCEAASFY WPDICFDESL
MNVIS
