ID   MYBA_CHICK              Reviewed;         757 AA.
AC   P52550;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Myb-related protein A;
DE            Short=A-Myb;
DE   AltName: Full=Myb-like protein 1;
GN   Name=MYBL1; Synonyms=AMYB;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8058311;
RA   Foos G., Grimm S., Klempnauer K.H.;
RT   "The chicken A-myb protein is a transcriptional activator.";
RL   Oncogene 9:2481-2488(1994).
CC   -!- FUNCTION: Strong transcriptional activator; DNA-binding protein that
CC       specifically recognize the sequence 5'-YAAC[GT]G-3'. Could have a role
CC       in the proliferation and/or differentiation of neurogenic,
CC       spermatogenic and B-lymphoid cells.
CC   -!- SUBUNIT: Component of the DREAM complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Expressed ubiquitously.
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DR   EMBL; X79470; CAA55980.1; -; mRNA.
DR   PIR; I50667; I50667.
DR   RefSeq; NP_990563.1; NM_205232.2.
DR   AlphaFoldDB; P52550; -.
DR   SMR; P52550; -.
DR   STRING; 9031.ENSGALP00000024981; -.
DR   PaxDb; P52550; -.
DR   GeneID; 396158; -.
DR   KEGG; gga:396158; -.
DR   CTD; 4603; -.
DR   VEuPathDB; HostDB:geneid_396158; -.
DR   eggNOG; KOG0048; Eukaryota.
DR   InParanoid; P52550; -.
DR   OrthoDB; 219341at2759; -.
DR   PhylomeDB; P52550; -.
DR   PRO; PR:P52550; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00167; SANT; 3.
DR   InterPro; IPR015395; C-myb_C.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR028317; MYBL1.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR012642; Tscrpt_reg_Wos2-domain.
DR   PANTHER; PTHR45614:SF9; PTHR45614:SF9; 1.
DR   Pfam; PF09316; Cmyb_C; 1.
DR   Pfam; PF07988; LMSTEN; 1.
DR   Pfam; PF00249; Myb_DNA-binding; 3.
DR   SMART; SM00717; SANT; 3.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS51294; HTH_MYB; 3.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..757
FT                   /note="Myb-related protein A"
FT                   /id="PRO_0000197056"
FT   DOMAIN          30..81
FT                   /note="HTH myb-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DOMAIN          82..137
FT                   /note="HTH myb-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DOMAIN          138..188
FT                   /note="HTH myb-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DNA_BIND        58..81
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DNA_BIND        110..133
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DNA_BIND        161..184
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   REGION          187..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          235..300
FT                   /note="Transcriptional activation domain"
FT                   /evidence="ECO:0000250"
FT   REGION          303..558
FT                   /note="Negative regulatory domain"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        194..209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   757 AA;  86009 MW;  69FC3B0CB9728B52 CRC64;
     MAKRPRTSEE DDDFQYADHD YEISQQRSLK KICNRVKWTR DEDEKLKKLV EQNGTDDWAF
     IASHLQNRSD FQCQHRWQKV LNPELIKGPW TKEEDQRVIE LVQKYGPKRW SLIAKHLKGR
     IGKQCRERWH NHLNPEVKKS SWTEAEDRVI YEAHKRLGNR WAEIAKLLPG RTDNSIKNHW
     NSTMRRKVEQ EGYLQDGTKS SSERTGSSTL AQKPCVTMEH LHTQNQFYIP VQTHIPVYQY
     ASPEDSCIEH ASASANLVQQ SFIDDDPDKE KKIKELELLL MSTENEIRRK RLSSQAGSLP
     GWSGSFVMED CVPNTLNSLG EQTSEFYSMD ETQGTSVQQN SPTKYLAVEA NAVLSSLQTI
     PEFAETLELI ESDPLAWSDV TSFDLSEAVA SPVKPAPLKL MRIQHNERAA ECQFNVSVML
     DGKKHSSISG EEEAVFPTTP NLTKYSTPPA ILRKKKRLRA GQSPVNELND GLCNDAINVA
     LKHTPVKTLP FSPSQFFNTC SGNEQFNLEN PAFTSTPICG QKVLITTPLH KETTPTDQKE
     NAGFRTPTIR RSLLGSTPRT PTPFKNALAA QEKKYGPLKL TSQPLAFLEE DIREVLKEET
     GTDIFLKEED DSVYKSCKQE HNSSKKVRKS LVLDAWEKEE LGAQLFTEDS GLDVQSENAY
     TTSLLMIPLL EIHDNRCNLP SENQDTNSSN KANAVIKKKL NACSSKNIKL EKSLQPNYEW
     EAVVYGKTED QLIMTEQARR YLNAYTATSN TSRALIL