MYBA_DICDI
ID MYBA_DICDI Reviewed; 1230 AA.
AC P34127; Q54B39;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 129.
DE RecName: Full=Myb-like protein A;
GN Name=mybA; ORFNames=DDB_G0293900;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-451.
RX PubMed=1549373;
RA Stober-Graesser U., Brydolf B., Bin X., Graesser F., Firtel R.A.,
RA Lipsick J.S.;
RT "The Myb DNA-binding domain is highly conserved in Dictyostelium
RT discoideum.";
RL Oncogene 7:589-596(1992).
CC -!- FUNCTION: May control cellular differentiation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1, Met-6, Met-110, Met-114 or Met-
CC 123 is the initiator. {ECO:0000305}.
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DR EMBL; AAFI02000224; EAL60449.1; -; Genomic_DNA.
DR EMBL; Z11534; CAB37862.1; -; Genomic_DNA.
DR RefSeq; XP_628877.1; XM_628875.1.
DR AlphaFoldDB; P34127; -.
DR SMR; P34127; -.
DR STRING; 44689.DDB0219992; -.
DR PaxDb; P34127; -.
DR EnsemblProtists; EAL60449; EAL60449; DDB_G0293900.
DR GeneID; 8629493; -.
DR KEGG; ddi:DDB_G0293900; -.
DR dictyBase; DDB_G0293900; mybA.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_267811_0_0_1; -.
DR InParanoid; P34127; -.
DR PRO; PR:P34127; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IDA:dictyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:dictyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd00167; SANT; 3.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00717; SANT; 3.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51294; HTH_MYB; 3.
PE 4: Predicted;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..1230
FT /note="Myb-like protein A"
FT /id="PRO_0000197062"
FT DOMAIN 144..195
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 196..251
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 252..302
FT /note="HTH myb-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 172..195
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 224..247
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 275..298
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 22..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 849..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1051..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1088..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1163..1230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..74
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..364
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..1000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1163..1218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 372
FT /note="I -> F (in Ref. 2; CAB37862)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1230 AA; 135979 MW; C82CC32B7AAB5CF8 CRC64;
MQPKRMSHNL TVGEKAGSPF NVILNAANNT NSDNSSNNSD NENDDNQNNN NNNNNNNNNN
NEEEEEEDDD DDDDSQQNRH NISIPFTINK NSINNNNNLI NNINNNINNM NNNMNNNNNN
NNMNNNINNN GNSNISNNNT PKVEKKKTKG KWTSEEDQIL IKAVNLHNQK NWKKIAEHFP
DRTDVQCHHR YQKVLHPNLV KGAWTKDEDD KVIELVKTYG PKKWSDIALH LKGRMGKQCR
ERWHNHLNPN IKKEAWSDEE DQIIRDQHAI HGNKWAEIAK FLPGRTDNAI KNHWNSSMKR
VSNNNVHLKS HAIEHSLSSQ DNQDSPKSII TSSSPIPTTT TTTTTTSTTL ITPPPPPLLP
PPPSINKKEK KIKQPKKRNA SEIEQTLSQP HINQHESSPI VFENISNGNN KIDIPAAQYL
MTNGISCINN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NINNNNNINN NNNNNNNINN
NNNNNNNNNN NNNNNNHSNV SANTNNNNNT INNNVSLQPP SQLNSNIAQL PSTPKNLAHV
NIANKLNSPG ELMANIVTPI KFFQTATVSM NSSSKNYNNE NTNNNNNNNN NHHHHHHNNN
NNNNKRPRLD FSSATPTKNN ESFSADLCSQ FPDILFSPIQ NKNNKESFLD NSGLSPLRSP
LHTNFFETPM KNYEYLDFNS PKIPNTISPL KNFNSPFNKI NNHSNYNNNN NNNNNNNNNN
NNNNNNNNNN NNNNNNNNNN NNHNPNHNSH NHNNHNNNHN HNHNEFAQPQ PPQGNYQQSP
YKNNSTTASS TLSTPSYSNN SSISSSSCSS SSSNSASKAT KVIQLSSSGI DKNSLLTINA
KLNNNHHKNY LDSSSSSSSS SSSSSSSSSS SSSSSSSSSS AASSSSTPNN QSDLATVPFT
PDDNVFNNNN NNNPPTPGKT KFKSRFSPNS KPYSYPQEYD NYGQSSSTPQ NINNTYNSIC
LGTNNNNNSN SSASNSFENN EENNNENDNN GSSSGGDKVP QMDSSFMALK LLKDNPNKSL
FSKARKILGL GNISSSSLSP SSFVQQISNS ASASSTPTSS SSTPLSSPTT TTSSVAAAII
NKISSTPKYF SNQNQNQNNN NNNNNNNISN NSNLSAFSTP GGNDHVPNFE SNSFLAQSPF
QDILNSQKLD QLHQLTQTNQ LSKSKVLLRN HKNSNQTESN SRSTIESINS NGSNNGNNSG
SSNSGSNSDK NNGKPISFRL MESSKPIEGL
