MYBB_DICDI
ID MYBB_DICDI Reviewed; 711 AA.
AC O15816; Q553D5; Q8MMQ3;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 25-MAY-2022, entry version 138.
DE RecName: Full=Myb-like protein B;
DE AltName: Full=Transcription factor Myb2;
GN Name=mybB; ORFNames=DDB_G0275445;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DEVELOPMENTAL STAGE, AND
RP DISRUPTION PHENOTYPE.
RC STRAIN=AX3 / DH1;
RX PubMed=9620859; DOI=10.1101/gad.12.11.1738;
RA Otsuka H., Van Haastert P.J.M.;
RT "A novel Myb homolog initiates Dictyostelium development by induction of
RT adenylyl cyclase expression.";
RL Genes Dev. 12:1738-1748(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Transcriptional activator that initiates multicellular
CC development by induction of adenylyl cyclase expression.
CC {ECO:0000269|PubMed:9620859}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- DEVELOPMENTAL STAGE: Expressed in vegetative cells, increases about 5-
CC fold during the first 2 hours of starvation and decreases rapidly
CC during the subsequent 4 hours of starvation.
CC {ECO:0000269|PubMed:9620859}.
CC -!- DISRUPTION PHENOTYPE: Cells display an aggregate-less phenotype.
CC {ECO:0000269|PubMed:9620859}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA05357.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ002383; CAA05357.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AAFI02000013; EAL69473.1; -; Genomic_DNA.
DR RefSeq; XP_643483.1; XM_638391.1.
DR AlphaFoldDB; O15816; -.
DR SMR; O15816; -.
DR STRING; 44689.DDB0215356; -.
DR PaxDb; O15816; -.
DR PRIDE; O15816; -.
DR EnsemblProtists; EAL69473; EAL69473; DDB_G0275445.
DR GeneID; 8620064; -.
DR KEGG; ddi:DDB_G0275445; -.
DR dictyBase; DDB_G0275445; mybB.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_388538_0_0_1; -.
DR InParanoid; O15816; -.
DR OMA; IMSRQTE; -.
DR PRO; PR:O15816; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; ISS:dictyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd00167; SANT; 3.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 3.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation.
FT CHAIN 1..711
FT /note="Myb-like protein B"
FT /id="PRO_0000328226"
FT DOMAIN 428..490
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 491..542
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 540..598
FT /note="Myb-like"
FT DNA_BIND 462..486
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 514..538
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 24..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 51
FT /note="Q -> QQQ (in Ref. 1; CAA05357)"
FT /evidence="ECO:0000305"
FT CONFLICT 172
FT /note="Missing (in Ref. 1; CAA05357)"
FT /evidence="ECO:0000305"
FT CONFLICT 202..221
FT /note="Missing (in Ref. 1; CAA05357)"
FT /evidence="ECO:0000305"
FT CONFLICT 331
FT /note="V -> VKQMLLKV (in Ref. 1; CAA05357)"
FT /evidence="ECO:0000305"
FT CONFLICT 666
FT /note="I -> N (in Ref. 1; CAA05357)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 711 AA; 81717 MW; 8576EFC2971EA26C CRC64;
MTAIFPNSNI PFYYWASTNA QPQQPQQSIQ QQQQQQQQQQ QQQQQQQQQQ QHHHHQNIPP
TPQPIFSPQL INKNFGCYGT SNQIPMIPQA LFPQQTFNYS GLPLCPSPPN YNNYHTITNS
PPHQIHSPQL TIDQHSPPTC VSGELSPTPL SSSTGFSNNN NNNNNNNNNN NNSNSNNNIN
NNNNNNIKRS YSAMMEENNY PNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NIINNNINSS
GSISSYSNNS CIEDDYSSDK HCSDKESSND CDDDADSYFE EYEDDQEAIR VSITPFVNLI
CKTPGITIPI IKIFSECSKE EITVKQMLLK VSLFLKIIIK IKIKIKIKIL IFYFLFFKKI
KNLCLEFNLD NSIHNTLIHS LVKIDGDIKM VKYLIDNGIS EQELEFTKDI LLTSNSQEII
KKKRERKRES ISRGIRSPPN KWTKEESQNL IKLVTENGDK QWKKIATKLG GGKTGAQCAQ
HWKRVLSPEI KKGSWDEAEE ELLFQLVDKH GQSWKNVAIE IKTRTDIQCR YQYFKAIMSR
QTEWNQLEDD ILTKKIKLMT QNNEKISFQQ VSKHLARAKT TKIPRTALEC KSRWSQLNST
NVNNNNNNNN NSITTSSSNT NQQQQSTMVT PTSSPLSSPI PMSTPIINNS MPQQQVQQIQ
QQQISIQPYP QSFIQETQGF YRGNDQMQYH IQNQTIPQYH HQHNNNPLLM L
