MYBC1_ARATH
ID MYBC1_ARATH Reviewed; 248 AA.
AC O22210;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Transcription factor MYBC1 {ECO:0000305};
GN Name=MYBC1 {ECO:0000303|PubMed:20331973};
GN Synonyms=MTF1 {ECO:0000303|PubMed:24255177};
GN OrderedLocusNames=At2g40970 {ECO:0000312|Araport:AT2G40970};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=20331973; DOI=10.1016/j.bbrc.2010.03.114;
RA Zhai H., Bai X., Zhu Y., Li Y., Cai H., Ji W., Ji Z., Liu X., Liu X.,
RA Li J.;
RT "A single-repeat R3-MYB transcription factor MYBC1 negatively regulates
RT freezing tolerance in Arabidopsis.";
RL Biochem. Biophys. Res. Commun. 394:1018-1023(2010).
RN [5]
RP BIOTECHNOLOGY.
RX PubMed=24255177; DOI=10.1126/scisignal.2004518;
RA Sardesai N., Lee L.Y., Chen H., Yi H., Olbricht G.R., Stirnberg A.,
RA Jeffries J., Xiong K., Doerge R.W., Gelvin S.B.;
RT "Cytokinins secreted by Agrobacterium promote transformation by repressing
RT a plant myb transcription factor.";
RL Sci. Signal. 6:RA100-RA100(2013).
CC -!- FUNCTION: Probable transcription factor that acts as a negative
CC regulator of freezing tolerance via a CBF-independent pathway.
CC {ECO:0000269|PubMed:20331973}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:20331973}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems, petioles,
CC filaments, stigma, pedicels, sepals, anthers, petals, and siliques.
CC {ECO:0000269|PubMed:20331973}.
CC -!- INDUCTION: Induced by drought, salt and abscisic acid (ABA). Down-
CC regulated by cold. {ECO:0000269|PubMed:20331973}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but mutant plants show increased tolerance to freezing.
CC {ECO:0000269|PubMed:20331973}.
CC -!- BIOTECHNOLOGY: Repression of MYBC1/MTF1 promotes Arabidopsis plant
CC transformation by Agrobacterium tumefaciens.
CC {ECO:0000269|PubMed:24255177}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC002409; AAB86457.1; -; Genomic_DNA.
DR EMBL; AC004261; AAM14927.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09908.1; -; Genomic_DNA.
DR EMBL; AY072381; AAL62373.1; -; mRNA.
DR EMBL; BT000098; AAN15417.1; -; mRNA.
DR PIR; T00761; T02122.
DR RefSeq; NP_181630.1; NM_129662.4.
DR AlphaFoldDB; O22210; -.
DR SMR; O22210; -.
DR IntAct; O22210; 2.
DR STRING; 3702.AT2G40970.1; -.
DR PaxDb; O22210; -.
DR PRIDE; O22210; -.
DR ProteomicsDB; 251391; -.
DR EnsemblPlants; AT2G40970.1; AT2G40970.1; AT2G40970.
DR GeneID; 818697; -.
DR Gramene; AT2G40970.1; AT2G40970.1; AT2G40970.
DR KEGG; ath:AT2G40970; -.
DR Araport; AT2G40970; -.
DR TAIR; locus:2058445; AT2G40970.
DR eggNOG; ENOG502RIEW; Eukaryota.
DR HOGENOM; CLU_055357_2_0_1; -.
DR InParanoid; O22210; -.
DR OMA; DSEYGHG; -.
DR OrthoDB; 1234988at2759; -.
DR PhylomeDB; O22210; -.
DR PRO; PR:O22210; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O22210; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0009409; P:response to cold; IMP:TAIR.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR044841; LUX/BOA-like.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR006447; Myb_dom_plants.
DR PANTHER; PTHR31442; PTHR31442; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR TIGRFAMs; TIGR01557; myb_SHAQKYF; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..248
FT /note="Transcription factor MYBC1"
FT /id="PRO_0000439516"
FT DNA_BIND 102..161
FT /note="Myb-like GARP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
SQ SEQUENCE 248 AA; 27554 MW; 6C68FB068C9A35D4 CRC64;
MREDNPNWFL RWEEELPSPE ELIPISQTLI TPHLALAFQI GSPNHHLGSK RTTAIYHQKL
QSSTTPTTPT PTPPPMMMNS DFGGGDSTDL GSGSIGGEPA RTLKRPRLVW TPQLHKRFVD
AVGHLGIKNA VPKTIMQLMS VEGLTRENVA SHLQKYRLYL RRMQGGNGNG ITGGHVIVSD
SATDRLFASS PVPAHFLSPD YLMPPLEHSY MGKHVITQQN QVVRNLRYED SEYGHGSMKM
LKLFPAGN
