MYBC_DICDI
ID MYBC_DICDI Reviewed; 580 AA.
AC Q54TN2; Q2V061; Q9GUB3;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Myb-like protein C;
GN Name=mybC; ORFNames=DDB_G0281563;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL
RP STAGE, AND MUTAGENESIS OF SER-434.
RX PubMed=10331990; DOI=10.1242/dev.126.12.2813;
RA Guo K., Anjard C., Harwood A., Kim H.-J., Newell P.C., Gross J.D.;
RT "A myb-related protein required for culmination in Dictyostelium.";
RL Development 126:2813-2822(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26.
RA Guo K., Newell P.C.;
RT "Promoter analysis of a myb gene in Dictyostelium.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription activator required for the culmination, at the
CC time of the fruiting body formation. Regulates genes involved in the
CC cell differentiation within the fruiting body.
CC {ECO:0000269|PubMed:10331990}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:10331990}.
CC -!- DEVELOPMENTAL STAGE: Expressed during the slug stage in prestalk cells
CC leading later to the fruiting body. {ECO:0000269|PubMed:10331990}.
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DR EMBL; AF098507; AAG15274.1; -; mRNA.
DR EMBL; AAFI02000042; EAL66543.1; -; Genomic_DNA.
DR EMBL; AF136752; AAQ13568.1; -; Genomic_DNA.
DR RefSeq; XP_640559.1; XM_635467.1.
DR AlphaFoldDB; Q54TN2; -.
DR SMR; Q54TN2; -.
DR STRING; 44689.DDB0214816; -.
DR PaxDb; Q54TN2; -.
DR EnsemblProtists; EAL66543; EAL66543; DDB_G0281563.
DR GeneID; 8623169; -.
DR KEGG; ddi:DDB_G0281563; -.
DR dictyBase; DDB_G0281563; mybC.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_470467_0_0_1; -.
DR InParanoid; Q54TN2; -.
DR OMA; YNAIVEF; -.
DR PRO; PR:Q54TN2; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0031154; P:culmination involved in sorocarp development; IMP:dictyBase.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:dictyBase.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:dictyBase.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 3.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation.
FT CHAIN 1..580
FT /note="Myb-like protein C"
FT /id="PRO_0000327826"
FT DOMAIN 368..430
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 431..482
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 484..546
FT /note="Myb-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT DNA_BIND 402..426
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 454..478
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 73..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 434
FT /note="S->A: No effect."
FT /evidence="ECO:0000269|PubMed:10331990"
FT MUTAGEN 434
FT /note="S->D: Loss of transcription activation activity."
FT /evidence="ECO:0000269|PubMed:10331990"
FT CONFLICT 29
FT /note="S -> I (in Ref. 1; AAG15274)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 580 AA; 65993 MW; A11738D7A59F3C45 CRC64;
MTMINPLSYP VPSQYSYTYN NNNNNSNNSS NNNSNNNSNN NNNNNNNCGV PNVSYGSNLN
QQSMAQDLRV PEQYSISSPS PKKRPFNSTM TTSPPTPTLL SNSPYIHGSH IVPQYSPQLQ
NVYNTPHQSS HSIHQPPQQT PNIFNNNNNN NNNNEKSNNQ NFGNTLFNSI TNNSSNSSNS
LIQQNNLTNN GSSSSSSSSS STNFNQNNNF INSSNDSIYN SNICSFYGNT SSSSSSSLNG
IESPPSVELM DDDIEDQLRE YISPVIWGMM DNYAREQFYN AIVEFINEEI SFRSLLLELR
VIAVMDVNYK SIFQFLVDLF LSIEPNQKMV NYLRDNGVEE NEFNIDLKSL ELSSDNDSNQ
KKKRERIRKS VSRGLRNPPN KWAKEESQKL IQLVHEHGDK QWKKIAHQIG GGKTGAQCAQ
HWKRVLCPAI RKGSWDEDEE SKLFNLVEKH GQSWKNVASE IRTRTDIQCR YQYFKSCMSR
EVQWSSREDE ILQKKVSENN QQDGTININN TRDISWMDVS KAMARGRQTK IPRTALECKT
RYFQLNFGGA PIQIVVPHND DHLNNPHSPL NSLLQDQNCY
