MYBC_MAIZE
ID MYBC_MAIZE Reviewed; 273 AA.
AC P10290; P23592; Q84V61;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Anthocyanin regulatory C1 protein;
GN Name=C1; Synonyms=C1-B73, C1-I, c1-I-2K1; ORFNames=Z438D03.27;
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3428265; DOI=10.1002/j.1460-2075.1987.tb02684.x;
RA Paz-Ares J., Ghosal D., Wienand U., Peterson P.A., Saedler H.;
RT "The regulatory c1 locus of Zea mays encodes a protein with homology to myb
RT proto-oncogene products and with structural similarities to transcriptional
RT activators.";
RL EMBO J. 6:3553-3558(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (C1-I).
RX PubMed=2303027; DOI=10.1002/j.1460-2075.1990.tb08113.x;
RA Paz-Ares J., Ghosal D., Saedler H.;
RT "Molecular analysis of the C1-I allele from Zea mays: a dominant mutant of
RT the regulatory C1 locus.";
RL EMBO J. 9:315-321(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (C1-I-2K1).
RC STRAIN=cv. 2K1 purple;
RX PubMed=15004287; DOI=10.1385/mb:26:3:187;
RA Chen B., Wang X., Hu Y., Wang Y., Lin Z.;
RT "Ectopic expression of a c1-I allele from maize inhibits pigment formation
RT in the flower of transgenic tobacco.";
RL Mol. Biotechnol. 26:187-192(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (C1-1162/C1-1170).
RA Cooper P., Cone K.C.;
RT "Identification of a new maize anthocyanin regulatory gene.";
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (C1-B73).
RC STRAIN=cv. B73;
RA Lai J., Swigonova Z., Ma J., Ramakrishna W., Bennetzen J.L., Messing J.;
RT "Extensive shuffling of gene order in genomes of the grass family.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Controls the expression of genes involved in anthocyanin
CC biosynthesis. Regulates the expression of at least 3 structural genes:
CC chalcone synthase, dihydroflavonol reductase and flavonol O(3)
CC glucosyltransferase. C1 acts as a trans-acting factor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- POLYMORPHISM: C1-1162 and C1-1170 alleles are identical to the wild-
CC type sequence. The C1-I allele is a dominant negative mutant which
CC inhibits pigment formation.
CC -!- MISCELLANEOUS: According to PubMed:2303027, C1-I allele might be
CC alternatively spliced, giving rise to a much smaller protein.
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DR EMBL; M37153; AAA33482.1; -; Genomic_DNA.
DR EMBL; X52201; CAA36456.1; -; Genomic_DNA.
DR EMBL; AY237128; AAO85386.1; -; mRNA.
DR EMBL; AF320613; AAK09326.1; -; Genomic_DNA.
DR EMBL; AF320614; AAK09327.1; -; Genomic_DNA.
DR EMBL; AY530950; AAT08011.1; -; Genomic_DNA.
DR PIR; S06215; TVZMMB.
DR RefSeq; NP_001106010.1; NM_001112540.1.
DR RefSeq; XP_008659144.1; XM_008660922.1.
DR AlphaFoldDB; P10290; -.
DR SMR; P10290; -.
DR STRING; 4577.GRMZM2G005066_P01; -.
DR PRIDE; P10290; -.
DR GeneID; 541757; -.
DR KEGG; zma:541757; -.
DR MaizeGDB; 24964; -.
DR eggNOG; KOG0048; Eukaryota.
DR OrthoDB; 1499244at2759; -.
DR Proteomes; UP000007305; Unplaced.
DR ExpressionAtlas; P10290; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..273
FT /note="Anthocyanin regulatory C1 protein"
FT /id="PRO_0000197063"
FT DOMAIN 9..65
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 66..116
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 37..61
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 89..112
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 137..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 77
FT /note="L -> LM (in allele C1-B73)"
FT VARIANT 101
FT /note="D -> E (in allele C1-I and allele C1-I-2K1)"
FT VARIANT 116..117
FT /note="Missing (in allele C1-I and allele C1-I-2K1)"
FT VARIANT 126
FT /note="W -> R (in allele C1-B73, allele C1-I and allele C1-
FT I-2K1)"
FT VARIANT 129
FT /note="V -> I (in allele C1-B73)"
FT VARIANT 145..146
FT /note="AC -> SG (in allele C1-B73 and allele C1-I)"
FT VARIANT 145..146
FT /note="AC -> SS (in allele C1-I-2K1)"
FT VARIANT 151..152
FT /note="NS -> KG (in allele C1-B73, allele C1-I and allele
FT C1-I-2K1)"
FT VARIANT 155
FT /note="H -> P (in allele C1-B73, allele C1-I and allele C1-
FT I-2K1)"
FT VARIANT 182
FT /note="G -> S (in allele C1-I and C1-I-2K1)"
FT VARIANT 205..206
FT /note="Missing (in allele C1-B73)"
FT VARIANT 208
FT /note="G -> GVG (in allele C1-I and allele C1-I-2K1)"
FT VARIANT 210
FT /note="G -> L (in allele C1-B73)"
FT VARIANT 218
FT /note="D -> E (in allele C1-B73)"
FT VARIANT 228
FT /note="L -> P (in allele C1-B73, allele C1-I and allele C1-
FT I-2K1)"
FT VARIANT 229
FT /note="R -> L (in allele C1-B73)"
FT VARIANT 233
FT /note="H -> Q (in allele C1-B73)"
FT VARIANT 244
FT /note="G -> C (in allele C1-B73)"
FT VARIANT 246..249
FT /note="WMDD -> SWTT (in allele C1-I-2K1)"
FT VARIANT 249..252
FT /note="DVRA -> SWTT (in allele C1-I)"
FT VARIANT 250..273
FT /note="Missing (in allele C1-I-2K1)"
FT VARIANT 253..273
FT /note="Missing (in allele C1-I)"
SQ SEQUENCE 273 AA; 28751 MW; 163977BBA8CE669D CRC64;
MGRRACCAKE GVKRGAWTSK EDDALAAYVK AHGEGKWREV PQKAGLRRCG KSCRLRWLNY
LRPNIRRGNI SYDEEDLIIR LHRLLGNRWS LIAGRLPGRT DNEIKNYWNS TLGRRAGAGA
GAGGSWVVVA PDTGSHATPA ATSGACETGQ NSAAHRADPD SAGTTTTSAA AVWAPKAVRC
TGGLFFFHRD TTPAHAGETA TPMAGGGGGG GGEAGSSDDC SSAASVSLRV GSHDEPCFSG
DGDGDWMDDV RALASFLESD EDWLRCQTAG QLA
