MYBH_DICDI
ID MYBH_DICDI Reviewed; 1217 AA.
AC Q54Z40;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Myb-like protein H;
GN Name=mybH; ORFNames=DDB_G0277927;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
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DR EMBL; AAFI02000023; EAL68136.1; -; Genomic_DNA.
DR RefSeq; XP_642011.1; XM_636918.1.
DR AlphaFoldDB; Q54Z40; -.
DR STRING; 44689.DDB0220617; -.
DR MEROPS; M67.A12; -.
DR PaxDb; Q54Z40; -.
DR EnsemblProtists; EAL68136; EAL68136; DDB_G0277927.
DR GeneID; 8621224; -.
DR KEGG; ddi:DDB_G0277927; -.
DR dictyBase; DDB_G0277927; mybH.
DR eggNOG; KOG0724; Eukaryota.
DR eggNOG; KOG1279; Eukaryota.
DR eggNOG; KOG1555; Eukaryota.
DR HOGENOM; CLU_269107_0_0_1; -.
DR InParanoid; Q54Z40; -.
DR OMA; KNHARIY; -.
DR PRO; PR:Q54Z40; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; ISS:dictyBase.
DR GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00167; SANT; 2.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR006447; Myb_dom_plants.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR007526; SWIRM.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR Pfam; PF04433; SWIRM; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 3.
DR TIGRFAMs; TIGR01557; myb_SHAQKYF; 2.
DR PROSITE; PS51294; HTH_MYB; 2.
DR PROSITE; PS50249; MPN; 1.
DR PROSITE; PS50934; SWIRM; 1.
PE 3: Inferred from homology;
KW DNA-binding; Hydrolase; Metal-binding; Metalloprotease; Nucleus; Protease;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..1217
FT /note="Myb-like protein H"
FT /id="PRO_0000329383"
FT DOMAIN 145..199
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 225..279
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 525..624
FT /note="SWIRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00247"
FT DOMAIN 778..921
FT /note="MPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT DNA_BIND 172..195
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 252..275
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 1..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 857..870
FT /note="JAMM motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT COMPBIAS 1..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1039..1070
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1081..1095
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 857
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT BINDING 859
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT BINDING 870
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ SEQUENCE 1217 AA; 136877 MW; 82568085181FD8E2 CRC64;
MTTQTKTSSP IQPSPIEQSP IQQSPIQQSP IQQSPILQSP IQRSPIQQLP IQQSPSISST
SFSNSNNDTN FNSKRLSNSI FPTSTSPVLS PLSPPLQPQP LISTSTSFNI NNNNNNNNNN
NNNNNNNNNN NNNNNNNNNT PKTTISGATR SSWTKEEERL FVEAYKLYDK DNKKIQEHVK
TKTILQVRSH AQKFALKLEK NGIKSLDNID QLFNQSHAAS SSHNLPSHNT PWSNEEHELF
LKAIEKYGRG NWKLISTLIK SRNTLQIKNH ARIYFDKISQ QNGPPSKKTI IEVENNNNYN
DQNNNNEQNN NNNNNNNNNN NNNNNNNSFF NGNDNGNNSS YSDNGNGNKS TSSKSDLSNT
RSSGSSSSSG SSSSSSSSTI SSGGSGGRSS GGSSGRSSGN SKKSSSKSKS KNPTSKPITP
IQPKLILPSR NIILSSAFST PTPTSISTFP KTPTYTTSNY KSSNNPLNRS FGSINNSSSN
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNKPPTK ERYLDLNIIT
QEEMMGCKEY FTGQISKTPD RYIKIRDKII RQWDSFKPNY LSKTFSRNQI KDCGSDINSI
GRVHQFLESI GVINFNAVGN PLNNNDYDRD NNNNNNNKNN NNNNNNNNNN NNNNNNNNNI
SDLSAILSSA ITNRMLENRK TNNPLRKRKI FYDGQWMDQS LLNTTIEHSG NENDKINMAT
SSTINNVNNS KTSSSSSPTN ESSKLYNFED FSSFPSFDPF TLVECKKYNN PNEQPFTIDV
SSNTMIVMDI HSHISSTEVI GMLGGKFNPD TNHITILLAI PCNSISSDIQ CDMDPNSQIA
AKEMVNSIGL DIVGWYHSHP NFEPIPSLRD IETQTSFQNL FATSSNNNNN NNKSMIEPFI
GFIVNPYHKN GLISNFNCIT ITKQMDETNQ YRIPYQLSTS YTPSLNNQYL YQQIDNLFEK
YKSYSSRIDL KKTMENGGFT HLDKMISSIS SNLILNNNSS SSNNKNNTNE SDLINCDEDI
IQDDQTELFL TKIKNQFKDF NNNNNNNNNN NNNNNNNNNN NNNNNNKNKN RNEGSRSRSR
SRSRSRSRSR SGTRSRSRSR SLDSYSRSRS RSGGNGYVGE KTLPKKHHHQ HLHNRHKSNT
FNDPDLSDSY MSEVSRSSSD YYNTESSSSM SDIEDDDISE YSDTENYKSF NKNNNNNNHY
NNNFLDKPVL QNKPSYQ
