MYBPH_MOUSE
ID MYBPH_MOUSE Reviewed; 483 AA.
AC P70402; E9QKH7;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Myosin-binding protein H;
DE Short=MyBP-H;
DE AltName: Full=H-protein;
GN Name=Mybph;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Ramos C.H.I., Fischman D.A., Reinach F.C.;
RL Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=28778945; DOI=10.1161/circulationaha.117.028585;
RA Barefield D.Y., Puckelwartz M.J., Kim E.Y., Wilsbacher L.D., Vo A.H.,
RA Waters E.A., Earley J.U., Hadhazy M., Dellefave-Castillo L., Pesce L.L.,
RA McNally E.M.;
RT "Experimental Modeling Supports a Role for MyBP-HL as a Novel Myofilament
RT Component in Arrhythmia and Dilated Cardiomyopathy.";
RL Circulation 136:1477-1491(2017).
CC -!- FUNCTION: Binds to myosin; probably involved in interaction with thick
CC myofilaments in the A-band.
CC -!- TISSUE SPECIFICITY: Skeletal muscle. Expressed at low levels in heart
CC ventricles. {ECO:0000269|PubMed:28778945}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. MyBP family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U68267; AAB08426.1; -; mRNA.
DR EMBL; AC137104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS35713.1; -.
DR RefSeq; NP_058029.2; NM_016749.2.
DR RefSeq; XP_006529817.1; XM_006529754.2.
DR RefSeq; XP_017177184.1; XM_017321695.1.
DR AlphaFoldDB; P70402; -.
DR BioGRID; 207275; 2.
DR IntAct; P70402; 1.
DR MINT; P70402; -.
DR STRING; 10090.ENSMUSP00000141104; -.
DR iPTMnet; P70402; -.
DR PhosphoSitePlus; P70402; -.
DR SWISS-2DPAGE; P70402; -.
DR MaxQB; P70402; -.
DR PaxDb; P70402; -.
DR PRIDE; P70402; -.
DR ProteomicsDB; 252625; -.
DR Antibodypedia; 34541; 214 antibodies from 27 providers.
DR DNASU; 53311; -.
DR Ensembl; ENSMUST00000038445; ENSMUSP00000042195; ENSMUSG00000042451.
DR Ensembl; ENSMUST00000191577; ENSMUSP00000141104; ENSMUSG00000042451.
DR GeneID; 53311; -.
DR KEGG; mmu:53311; -.
DR UCSC; uc007crh.1; mouse.
DR CTD; 4608; -.
DR MGI; MGI:1858196; Mybph.
DR VEuPathDB; HostDB:ENSMUSG00000042451; -.
DR eggNOG; ENOG502QVIQ; Eukaryota.
DR GeneTree; ENSGT00940000158040; -.
DR HOGENOM; CLU_037185_0_0_1; -.
DR InParanoid; P70402; -.
DR OMA; AHIQKTD; -.
DR OrthoDB; 653839at2759; -.
DR PhylomeDB; P70402; -.
DR TreeFam; TF334735; -.
DR BioGRID-ORCS; 53311; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Mybph; mouse.
DR PRO; PR:P70402; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; P70402; protein.
DR Bgee; ENSMUSG00000042451; Expressed in hindlimb stylopod muscle and 72 other tissues.
DR Genevisible; P70402; MM.
DR GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; -; 4.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 2.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Cell adhesion; Immunoglobulin domain; Muscle protein; Phosphoprotein;
KW Reference proteome; Repeat; Thick filament.
FT CHAIN 1..483
FT /note="Myosin-binding protein H"
FT /id="PRO_0000072699"
FT DOMAIN 79..174
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 178..266
FT /note="Ig-like C2-type 1"
FT DOMAIN 275..370
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 388..472
FT /note="Ig-like C2-type 2"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O88599"
FT MOD_RES 6
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O88599"
FT MOD_RES 26
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O88599"
FT CONFLICT 249
FT /note="R -> C (in Ref. 1; AAB08426)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 483 AA; 52641 MW; C8E8653EBEC6F169 CRC64;
MTGKATSEAS VSTPEETAPE PAKVPTTEPS GEVAASESTG QEQAPEPQKP QAQDPAAPAA
SAMPAATKPE PPSEDVPSAP LRLTLEDVSH SSLTVSWEPP EKLGKLGLQG YVLEFCREGA
SEWVPVNPRP VMVTQQTVRN LALGDKFFLR VTAVSSAGAG PPAVLDQPVH IQEITEAPKI
RVPRHLRQTY IRQVGESVNL QIPFQGKPKP QVSWTHNGHA LDNQRVNVRS GDQDSILFIR
SAQRADSGRY ELTVHLEGLE AKASIDILVI EKPGPPSSIK LLDVWGCNAA LEWTPPQDTG
NTELLGYTVQ KADKRTGQWF TVLERYHPTT CTISDLIIGN SYSFRVFSEN LCGLSDLATT
TKELAHIHKA DITAKPREFI ERDFSEAPSF TQPLADHTST PGYSTQLFCS VRASPKPKII
WMKNKMDIQG DPKYRAVSEQ GVCTLEIRKP SPFDSGVYTC KAINVLGEAS VDCRLEVKAS
ATH
