MYBPP_RAT
ID MYBPP_RAT Reviewed; 928 AA.
AC Q69CM7; Q69CM6;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=MYCBP-associated protein;
DE AltName: Full=Organ of Corti membrane-associated protein of 106 kDa;
GN Name=Mycbpap {ECO:0000312|RGD:1359123}; Synonyms=Cod106;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAR10437.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR
RP LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=Wistar {ECO:0000312|EMBL:AAR10437.1};
RC TISSUE=Cochlea {ECO:0000312|EMBL:AAR10437.1};
RX PubMed=15607946; DOI=10.1016/j.mcn.2004.08.018;
RA Reisinger E., Zimmermann U., Knipper M., Ludwig J., Kloecker N., Fakler B.,
RA Oliver D.;
RT "Cod106, a novel synaptic protein expressed in sensory hair cells of the
RT inner ear and in CNS neurons.";
RL Mol. Cell. Neurosci. 28:106-117(2005).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-558 AND SER-564, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: May play a role in spermatogenesis (By similarity). May be
CC involved in synaptic processes. {ECO:0000250|UniProtKB:Q8TBZ2,
CC ECO:0000269|PubMed:15607946}.
CC -!- SUBUNIT: Interacts with MYCBP. {ECO:0000250|UniProtKB:Q8TBZ2}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15607946}. Membrane
CC {ECO:0000269|PubMed:15607946}. Note=Colocalizes with MYCBP in the
CC cytoplasm. {ECO:0000250|UniProtKB:Q8TBZ2, ECO:0000269|PubMed:15607946}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:15607946}; Synonyms=Cod106a
CC {ECO:0000269|PubMed:15607946};
CC IsoId=Q69CM7-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:15607946}; Synonyms=Cod106b
CC {ECO:0000269|PubMed:15607946};
CC IsoId=Q69CM7-2; Sequence=VSP_052546;
CC -!- TISSUE SPECIFICITY: Expressed in brain, retina, testis, heart and lung.
CC Not detected in liver, kidney or intestine. In brain, highly abundant
CC in CNS neurons of the hippocampus and cerebellum. Strongly expressed in
CC cochlea and vestibular sensory epithelia. In both the organ of Corti
CC and the vestibular organ, expression is restricted to hair cells.
CC {ECO:0000269|PubMed:15607946}.
CC -!- DEVELOPMENTAL STAGE: After birth, expression in the organ of Corti
CC increases about 10-fold by postnatal day 5 (P5) and remains at constant
CC levels thereafter. {ECO:0000269|PubMed:15607946}.
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DR EMBL; AY353958; AAR10437.1; -; mRNA.
DR EMBL; AY353959; AAR10438.1; -; mRNA.
DR RefSeq; NP_001009482.1; NM_001009482.1. [Q69CM7-2]
DR AlphaFoldDB; Q69CM7; -.
DR STRING; 10116.ENSRNOP00000067004; -.
DR iPTMnet; Q69CM7; -.
DR PhosphoSitePlus; Q69CM7; -.
DR PaxDb; Q69CM7; -.
DR PRIDE; Q69CM7; -.
DR GeneID; 494192; -.
DR KEGG; rno:494192; -.
DR CTD; 84073; -.
DR RGD; 1359123; Mycbpap.
DR eggNOG; ENOG502QT8X; Eukaryota.
DR InParanoid; Q69CM7; -.
DR OrthoDB; 650849at2759; -.
DR PhylomeDB; Q69CM7; -.
DR PRO; PR:Q69CM7; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0019897; C:extrinsic component of plasma membrane; TAS:RGD.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007268; P:chemical synaptic transmission; IEP:UniProtKB.
DR GO; GO:0007605; P:sensory perception of sound; IEP:RGD.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032707; MYCBPAP.
DR Pfam; PF14646; MYCBPAP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Developmental protein; Differentiation;
KW Membrane; Phosphoprotein; Reference proteome; Spermatogenesis.
FT CHAIN 1..928
FT /note="MYCBP-associated protein"
FT /id="PRO_0000302879"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..867
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 557
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5SUV2"
FT MOD_RES 558
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 564
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT VAR_SEQ 1..14
FT /note="MKKANDRQSPPKLL -> MTPWRSLAPHVTSRGRR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15607946"
FT /id="VSP_052546"
SQ SEQUENCE 928 AA; 106345 MW; 5583ED101F5E0E53 CRC64;
MKKANDRQSP PKLLEKKRAK APEQPTPPIQ EEPEPVSNVL QGDDILALAI KKEDLTKQHI
PQFEETGEKP VVTQKFIIRK LKPKDSCKRV YHLVAHPANP DATTKPLDYS GPRDSFLSSD
QILPHQILGS LQDFKRIAVA RGNTQLAKLI NIQPCLMTLI SAKEEPKPKS PKEEKRPPWA
PPLQHNFLKN WRRHITLRKK QQEVLSEHLK KPASELLMNS GEGYRKIQEE REAIDRALPT
QHDRKAMNCF WSPLEYLGDE KSGLLMTKKK KQRGLVEPIT HIRKPFSIQM ETGLPVQKDA
WYRYTWDRSL FLIYRRKGLQ NIMAELDFSQ QDIDGLEVVG HGKPFSSVTV EEPLPLEKSQ
KSSSEDTVFL DSLTNLSDMV PMPILGPSLL FCGKPACWIR GSNPEDKKNI GIGVRLTFET
LEGEKTSSEL TVVNNGTVAI WYDWRRRPQQ DFFQDLKQNR TQRFYFNNRE GVILPGETKH
FTFFFKSRNA GIFMESWEFG THPTLLGGAA LQITLHAISL TQDIFMDERK LLESKLAAHE
AVTIAQSVLQ DLLRGVSTPE RAPSPVDAYL TEEDLFHYRN PRLHYQHRVV QNLHQLWQQY
TEAKASQEEA LNLRTPTVPL LFVEKPPDHS RTLASEYPQL QPHQEMDTLK DPKNSLLPQK
TGISTKSMQR KSIMEEILVE EGPDRENTRS PRVLENLPPP KWNLCLEDFR QAVMTFPEEL
QREDALIQLN KAAMELCQEQ KPLQSDLLYQ MCLQLWRDVI DSLVSQSLWL RSLLGLPEKE
TVYLDIPDEG QKSPPVTEVK VTSGKLGKED RRGGAQEKKQ LSARDKEEKK GSKTPSKEDR
LNSKKQKAKD DKKVVKSTSR DRLLSEDPPA DSSATSQEPI DPLVMEKYTQ RLYSEVYGLL
DNLVIDMMVL ADELGSEKNV EEPLRFCT
