MYB_AVIMB
ID MYB_AVIMB Reviewed; 382 AA.
AC P01104; Q83871; Q90954;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 2.
DT 29-SEP-2021, entry version 119.
DE RecName: Full=Transforming protein Myb;
GN Name=V-MYB;
OS Avian myeloblastosis virus.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Alpharetrovirus.
OX NCBI_TaxID=11866;
OH NCBI_TaxID=8976; Galliformes.
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=6297766; DOI=10.1016/0092-8674(82)90138-6;
RA Klempnauer K.-H., Gonda T.J., Bishop J.M.;
RT "Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular
RT progenitor c-myb: the architecture of a transduced oncogene.";
RL Cell 31:453-463(1982).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6283631; DOI=10.1126/science.6283631;
RA Rushlow K.E., Lautenberger J.A., Papas T.S., Baluda M.A., Perbal B.,
RA Chirikjian J.G., Reddy E.P.;
RT "Nucleotide sequence of the transforming gene of avian myeloblastosis
RT virus.";
RL Science 216:1421-1423(1982).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=8084581;
RA Baluda M.A., Reddy E.P.;
RT "Anatomy of an integrated avian myeloblastosis provirus: structure and
RT function.";
RL Oncogene 9:2761-2774(1994).
CC -!- FUNCTION: DNA-binding protein that specifically recognizes the sequence
CC 5'-YAAC[GT]G-3'. The v-Myb oncogene transforms immature myelomonocytic
CC avian cells in culture and induces myeloblastosis (myeloid leukemia) in
CC chickens.
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000305}.
CC -!- DOMAIN: The absence of the N- and/or C-terminal may prevent homodimer
CC formation, leading to DNA-binding and its increased transactivation
CC activity.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA42553.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAC15907.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; J02012; AAA42553.1; ALT_INIT; Genomic_RNA.
DR EMBL; S74099; AAB31930.2; -; Genomic_RNA.
DR EMBL; J02013; AAC15907.1; ALT_INIT; Genomic_DNA.
DR PIR; A36314; QOYV.
DR PDB; 1H8A; X-ray; 2.23 A; C=1-122.
DR PDBsum; 1H8A; -.
DR BMRB; P01104; -.
DR SMR; P01104; -.
DR IntAct; P01104; 2.
DR EvolutionaryTrace; P01104; -.
DR Proteomes; UP000235313; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR015395; C-myb_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR012642; Tscrpt_reg_Wos2-domain.
DR Pfam; PF09316; Cmyb_C; 1.
DR Pfam; PF07988; LMSTEN; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Host nucleus; Oncogene; Repeat.
FT CHAIN 1..382
FT /note="Transforming protein Myb"
FT /id="PRO_0000197053"
FT DOMAIN 1..15
FT /note="Myb-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT DOMAIN 16..71
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 72..122
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 44..67
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 95..118
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 119..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..256
FT /note="Transcriptional activation domain"
FT /evidence="ECO:0000250"
FT REGION 257..376
FT /note="Negative regulatory domain (incomplete)"
FT /evidence="ECO:0000250"
FT REGION 305..326
FT /note="Leucine-zipper"
FT HELIX 26..38
FT /evidence="ECO:0007829|PDB:1H8A"
FT HELIX 44..50
FT /evidence="ECO:0007829|PDB:1H8A"
FT STRAND 51..53
FT /evidence="ECO:0007829|PDB:1H8A"
FT HELIX 56..65
FT /evidence="ECO:0007829|PDB:1H8A"
FT STRAND 69..71
FT /evidence="ECO:0007829|PDB:1H8A"
FT HELIX 78..91
FT /evidence="ECO:0007829|PDB:1H8A"
FT HELIX 95..98
FT /evidence="ECO:0007829|PDB:1H8A"
FT HELIX 99..101
FT /evidence="ECO:0007829|PDB:1H8A"
FT HELIX 107..115
FT /evidence="ECO:0007829|PDB:1H8A"
FT TURN 116..119
FT /evidence="ECO:0007829|PDB:1H8A"
SQ SEQUENCE 382 AA; 43061 MW; 1459BACAD29EC971 CRC64;
NRTDVQCQHR WQKVLNPELN KGPWTKEEDQ RVIEHVQKYG PKRWSDIAKH LKGRIGKQCR
ERWHNHLNPE VKKTSWTEEE DRIIYQAHKR LGNRWAEIAK LLPGRTDNAV KNHWNSTMRR
KVEQEGYPQE SSKAGPPSAT TGFQKSSHLM AFAHNPPAGP LPGAGQAPLG SDYPYYHIAE
PQNVPGQIPY PVALHINIIN VPQPAAAAIQ RHYTDEDPEK EKRIKELELL LMSTENELKG
QQALPTQNHT ANYPGWHSTT VADNTRTSGD NAPVSCLGEH HHCTPSPPVD HGCLPEESAS
PARCMIVHQS NILDNVKNLL EFAETLQLID SFLNTSSNHE NLNLDNPALT STPVCGHKMS
VTTPFHKDQT FTEYRKMHGG AV
