ID   MYB_XENLA               Reviewed;         624 AA.
AC   Q08759;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Transcriptional activator Myb;
GN   Name=myb;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7509053;
RA   Amaravadi L., King M.W.;
RT   "Characterization and expression of the Xenopus c-Myb homolog.";
RL   Oncogene 9:971-974(1994).
CC   -!- FUNCTION: Transcriptional activator; DNA-binding protein that
CC       specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important
CC       role in the control of proliferation and differentiation of
CC       hematopoietic progenitor cells.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: Comprised of 3 domains; an N-terminal DNA-binding domain, a
CC       centrally located transcriptional activation domain and a C-terminal
CC       domain involved in transcriptional repression.
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DR   EMBL; L22741; AAC38011.1; -; mRNA.
DR   PIR; I51581; I51581.
DR   RefSeq; NP_001081768.1; NM_001088299.2.
DR   AlphaFoldDB; Q08759; -.
DR   SMR; Q08759; -.
DR   GeneID; 398039; -.
DR   KEGG; xla:398039; -.
DR   CTD; 398039; -.
DR   Xenbase; XB-GENE-867566; myb.S.
DR   OrthoDB; 219341at2759; -.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 398039; Expressed in egg cell and 11 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00167; SANT; 3.
DR   InterPro; IPR015395; C-myb_C.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR012642; Tscrpt_reg_Wos2-domain.
DR   Pfam; PF09316; Cmyb_C; 1.
DR   Pfam; PF07988; LMSTEN; 1.
DR   Pfam; PF00249; Myb_DNA-binding; 3.
DR   SMART; SM00717; SANT; 3.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS51294; HTH_MYB; 3.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..624
FT                   /note="Transcriptional activator Myb"
FT                   /id="PRO_0000197051"
FT   DOMAIN          32..83
FT                   /note="HTH myb-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DOMAIN          84..139
FT                   /note="HTH myb-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DOMAIN          140..190
FT                   /note="HTH myb-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DNA_BIND        60..83
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DNA_BIND        112..135
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DNA_BIND        163..186
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   REGION          264..314
FT                   /note="Transcriptional activation domain"
FT                   /evidence="ECO:0000250"
FT   REGION          315..449
FT                   /note="Negative regulatory domain"
FT                   /evidence="ECO:0000250"
FT   REGION          319..352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..351
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   624 AA;  72112 MW;  B8F51A2BBA72E70B CRC64;
     MDRRPSQYSS EEEDDEIEMY EHDYDGLLSK GKRHLGKTRW TREEDEKLKK LVEQNGTEEW
     KVIASFLPNR TDVQCQHRWQ KVLNPELIKG PWTKEEDQRV IELVHKYGPK RWSVIAKHLK
     GRIGKQCRER WHNHLNPEVK KSSWTEEEDR TIYEAHKRLG NRWAEIAKLL PGRTDNAIKN
     HWNSTMRRKE EQEGYLQNSS KTNQHTIVTN FPKSNHLMTF THTRASAEHS QASTSSFPYY
     HIAEHQNASY PVALRVNIVN VPQLATAPVQ RHYNDEDPEK EKRIKELELL LMSTENEINQ
     KQELLNHTAS YTTCHSTTIG GNPRLHGQST PDSCLGDPHH STPSPQVDHS CLPEESASPA
     RYFGVNLLIQ MKNLAEYSET QLIDSFLNTS TQHENLEMEH QSLTSTPICA SQKNTITTSL
     LRDHALRLQK ENHLLRTPAI KRSILNSTPR TPTPFKNALA AQEFKHGPLK LLHHTPLHLA
     EDIQEVIKQE TDESGIVHDH CNTEEPLLKR IKQEVESPTH KVGNLYFSSY WEGESLNAQL
     FRQQSTLDDT SNSILTSSLL MKPVSEKEDH IFKSFPVQSI KSYTSPLQHL SGTWDVMSCS
     RMEDQKILAE QYCKYIKNFS TLVI