MYC1_SOLLC
ID MYC1_SOLLC Reviewed; 630 AA.
AC A0A060KY90; A0A3Q7HIZ7;
DT 03-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT 03-SEP-2014, sequence version 1.
DT 25-MAY-2022, entry version 36.
DE RecName: Full=Transcription factor MYC1 {ECO:0000303|PubMed:24884371};
DE Short=SlMYC1 {ECO:0000303|PubMed:24884371};
GN Name=MYC1 {ECO:0000303|PubMed:24884371};
GN Synonyms=JAMYC10 {ECO:0000303|PubMed:15231736};
GN OrderedLocusNames=Solyc08g005050 {ECO:0000305};
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Moneymaker;
RX PubMed=24884371; DOI=10.1186/1471-2164-15-402;
RA Spyropoulou E.A., Haring M.A., Schuurink R.C.;
RT "RNA sequencing on Solanum lycopersicum trichomes identifies transcription
RT factors that activate terpene synthase promoters.";
RL BMC Genomics 15:402-402(2014).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Heinz 1706;
RX PubMed=22660326; DOI=10.1038/nature11119;
RG Tomato Genome Consortium;
RT "The tomato genome sequence provides insights into fleshy fruit
RT evolution.";
RL Nature 485:635-641(2012).
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=15231736; DOI=10.1101/gad.297704;
RA Boter M., Ruiz-Rivero O., Abdeen A., Prat S.;
RT "Conserved MYC transcription factors play a key role in jasmonate signaling
RT both in tomato and Arabidopsis.";
RL Genes Dev. 18:1577-1591(2004).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF GLU-161.
RX PubMed=30518626; DOI=10.1105/tpc.18.00571;
RA Xu J., van Herwijnen Z.O., Draeger D.B., Sui C., Haring M.A.,
RA Schuurink R.C.;
RT "SlMYC1 regulates type VI glandular trichome formation and terpene
RT biosynthesis in tomato glandular cells.";
RL Plant Cell 30:2988-3005(2018).
CC -!- FUNCTION: Transcriptional activator that binds to the G-box motif (5'-
CC AACGTG-3') found in a number of promoters of jasmonate-induced genes
CC (PubMed:15231736). Transcription activator involved in the
CC transcriptional regulation of terpene biosynthesis in glandular
CC trichomes (PubMed:24884371, PubMed:30518626). Binds to the promoter of
CC the linalool synthase TPS5 and promotes TPS5 gene transactivation
CC (PubMed:24884371). Acts synergistically with EOT1 in the
CC transactivation of TPS5 (PubMed:24884371). Involved in type VI
CC glandular trichome development (PubMed:30518626). Involved in the
CC activation of terpene synthases required for volatile mono- and
CC sesquiterpenes synthesis by the glandular cells of type VI trichomes
CC (PubMed:30518626). {ECO:0000269|PubMed:15231736,
CC ECO:0000269|PubMed:24884371, ECO:0000269|PubMed:30518626}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Highly expressed in trichomes and at lower levels
CC in leaves and flowers (PubMed:24884371). Expressed at low levels in
CC roots, stems, leaves, flowers and fruits (PubMed:15231736).
CC {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24884371}.
CC -!- INDUCTION: Induced by methyl jasmonate and wounding.
CC {ECO:0000269|PubMed:15231736}.
CC -!- DISRUPTION PHENOTYPE: Altered morphology of type VI glandular trichomes
CC (PubMed:30518626). Strong reduction of volatile terpene synthesis in
CC trichomes (PubMed:30518626). Strong reduction of the expression of
CC terpene synthase genes in trichomes (PubMed:30518626).
CC {ECO:0000269|PubMed:30518626}.
CC -!- CAUTION: Contains a degenerate basic motif not likely to bind DNA.
CC {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR EMBL; KF430611; AIC63945.1; -; mRNA.
DR EMBL; CM001071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001288107.1; NM_001301178.2.
DR AlphaFoldDB; A0A060KY90; -.
DR SMR; A0A060KY90; -.
DR GeneID; 101261048; -.
DR KEGG; sly:101261048; -.
DR OrthoDB; 371763at2759; -.
DR Proteomes; UP000004994; Unplaced.
DR ExpressionAtlas; A0A060KY90; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0010090; P:trichome morphogenesis; IMP:UniProtKB.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR045084; AIB/MYC-like.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR025610; MYC/MYB_N.
DR PANTHER; PTHR11514; PTHR11514; 1.
DR Pfam; PF14215; bHLH-MYC_N; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Stress response; Transcription; Transcription regulation.
FT CHAIN 1..630
FT /note="Transcription factor MYC1"
FT /id="PRO_0000447546"
FT DOMAIN 453..502
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 356..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..466
FT /note="Basic motif; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 467..502
FT /note="Helix-loop-helix motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT COMPBIAS 379..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 161
FT /note="E->K: Enhanced transcriptional activity."
FT /evidence="ECO:0000269|PubMed:30518626"
SQ SEQUENCE 630 AA; 69347 MW; 871E856EACD94CE0 CRC64;
MTDYRLWSNT NTTNTCDDTM MMDSFLSSDP SSFWPASTPN RPTPVNGVGE TMPFFNQESL
QQRLQALIDG ARESWAYAIF WQSSVVDFAS QTVLGWGDGY YKGEEDKNKR RGSSSSAANF
VAEQEHRKKV LRELNSLISG VQASAGNGTD DAVDEEVTDT EWFFLISMTQ SFVNGNGLPG
LAMYSSSPIW VTGTEKLAAS QCERARQAQG FGLQTIVCIP SANGVVELGS TELIFQSSDL
MNKVKYLFNF NIDMGSVTGS GSGSGSCAVH PEPDPSALWL TDPSSSVVEP KDSLIHSSSR
DVQLVYGNEN SENQQQHCQG FFTKELNFSG YGFDGSSNRN KTGISCKPES REILNFGDSS
KRFSGQSQLG PGPGLMEENK NKNKNKKRSL GSRGNNEEGM LSFVSGVILP TSTMGKSGDS
DHSDLEASVV KEAVVEPEKK PRKRGRKPAN GREEPLNHVE AERQRREKLN QRFYALRAVV
PNVSKMDKAS LLGDAIAYIN ELKSKVQNSD LDKEELRSQI ECLRKELTNK GSSNYSASPP
LNQDVKIVDM DIDVKVIGWD AMIRIQCSKK NHPAARLMAA LKDLDLDVHH ASVSVVNDLM
IQQATVKMGS RLYAQEQLRI ALTSKIAESR
