ID   MYC2_MARMO              Reviewed;         454 AA.
AC   P20389;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=N-myc 2 proto-oncogene protein;
GN   Name=N-MYC2;
OS   Marmota monax (Woodchuck).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Marmota.
OX   NCBI_TaxID=9995;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2205804; DOI=10.1038/347294a0;
RA   Fourel G., Trepo G., Bougueleret L., Henglein B., Ponzetto A., Tiollais P.,
RA   Buendia M.-A.;
RT   "Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck
RT   liver tumours.";
RL   Nature 347:294-298(1990).
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- DISEASE: Note=N-MYC2 proto-oncogene protein is overexpressed in liver
CC       tumors. N-MYC2 is totally silent in normal liver and is probably a
CC       retroposon. WHV virus activates N-MYC2 by integration.
CC       {ECO:0000269|PubMed:2205804}.
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DR   EMBL; X53671; CAA37711.1; -; Genomic_DNA.
DR   PIR; S11511; S11511.
DR   AlphaFoldDB; P20389; -.
DR   SMR; P20389; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR002418; Tscrpt_reg_Myc.
DR   InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF01056; Myc_N; 1.
DR   PIRSF; PIRSF001705; Myc_protein; 1.
DR   PRINTS; PR00044; LEUZIPPRMYC.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Proto-oncogene.
FT   CHAIN           1..454
FT                   /note="N-myc 2 proto-oncogene protein"
FT                   /id="PRO_0000127331"
FT   DOMAIN          371..423
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          132..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          230..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          325..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          423..444
FT                   /note="Leucine-zipper"
FT   COMPBIAS        334..349
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        359..374
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   454 AA;  49587 MW;  D889C3821C0F5745 CRC64;
     MRSCTVSTMP RMICRNADLE FDWLQPCFYP DEDDFYFSGP NSTPPGEDIW KKFELLPTPP
     LSPSCAFLEL STEPSDWASE MMLTEADLWG NPDEEDVFGP GGLGSLTPNP VILRDCMWSG
     FSAREKLERA MSEKMQHGHE PAATGPATQV PGAGAASPAG RGHSGTAGAA LPAELAHPAA
     ECVDPAVVFL LPVSKRNPVP VRVAPARAPA RASAVGAAVA RAAAPATAAV AAPPGLSSRP
     PNGGDHKVLS TSGEDALSDE VDEEEDEEEE IDVVTVEKSC KTGGTTFTLT VSPKNTALGL
     GREQSRELIL QRSVPIYQQH NYAAPSPYVE SEDAPPQKKI KREVSPHPLK SVIHPKGKSF
     SPRKSDSEDS VRRRNHNILE RQRRNDLRSS FTTLRDHVPE LVKNEKAAKV VILKKACEYV
     HYLQAKEHQL LMEKEKLQAR QQQLLKIIEL AWTF